Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Clinical and animal model applications

(2015) Sarah F. Cook et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury

(2014) Sujith V. W. Weerasinghe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans

(2014) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

(2014) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

(2013) Mitchell R. McGill et al.   ARCHIVES OF TOXICOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Case of Moderate Liver Enzyme Elevation After Acute Acetaminophen Overdose Despite Undetectable Acetaminophen Level and Normal Initial Liver Enzymes

(2012) Vikhyat S. Bebarta et al.   AMERICAN JOURNAL OF THERAPEUTICS

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and death

(2012) Christopher H. Remien et al.   HEPATOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Acute Liver Failure

(2012) William Lee   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Emergency Department Visits for Overdoses of Acetaminophen-Containing Products

(2011) Daniel S. Budnitz et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

(2011) Kennon J Heard et al.   BMC GASTROENTEROLOGY

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

(2009) L. P. James et al.   DRUG METABOLISM AND DISPOSITION

Acetaminophen Hepatotoxicity and Acute Liver Failure

(2009) Linda J. Chun et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose

(2008) LP James et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS