Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

(2012) A H Harrill et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic biomarkers in acute liver injury: Are we there yet?

(2012) Danielle Adebayo et al.   JOURNAL OF HEPATOLOGY

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity

(2011) Darren G. N. Craig et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Meta-analysis of performance of Kings’s College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure

(2010) Mark J.W. McPhail et al.   JOURNAL OF HEPATOLOGY

Acute liver failure

(2010) William Bernal et al.   LANCET

Detailed analyses of self-poisoning episodes presenting to a large regional teaching hospital in the UK

(2009) Katherine Prescott et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose

(2009) W. Stephen Waring et al.   CLINICAL TOXICOLOGY

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress

(2009) D.J. Antoine et al.   XENOBIOTICA

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

(2008) J. Cummings et al.   MOLECULAR CANCER THERAPEUTICS