DEPTOR at the Nexus of Cancer, Metabolism, and Immunity

mTOR signaling in stem and progenitor cells

(2018) Delong Meng et al.   DEVELOPMENT

Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR

(2018) Thawfeek M. Varusai et al.   Scientific Reports

Different functions of DEPTOR in modulating sensitivity to chemotherapy for esophageal squamous cell carcinoma

(2017) Xiaoying Dong et al.   EXPERIMENTAL CELL RESEARCH

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

(2017) Haiyan Tan et al.   IMMUNITY

DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma

(2017) Dalia Quwaider et al.   Journal of Hematology & Oncology

Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

(2017) Zhuo-Xian Meng et al.   MOLECULAR CELL

Metabolic control of myofibers: promising therapeutic target for obesity and type 2 diabetes

(2017) Yehui Duan et al.   Obesity Reviews

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway

(2017) Binwu Hu et al.   OncoTargets and Therapy

The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control

(2017) Ruo-Ran Wang et al.   Protein & Cell

DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture

(2017) Qi-bing Xie et al.   Journal of Immunology Research

Promotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

(2017) Si Chen et al.   Stem Cell Reports

Amino acid sensing in hypothalamic tanycytes via umami taste receptors

(2017) Greta Lazutkaite et al.   Molecular Metabolism

Loss of hepatic DEPTOR alters the metabolic transition to fasting

(2017) Alexandre Caron et al.   Molecular Metabolism

Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer

(2017) Kenji Ohshima et al.   Scientific Reports

DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance

(2016) Alexandre Caron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

(2016) Alexandre Caron et al.   Annals of the New York Academy of Sciences

Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway

(2016) W Wang et al.   BRITISH JOURNAL OF CANCER

Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells

(2016) Yijiang Shi et al.   CANCER RESEARCH

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II

(2016) Kenjiro Muta et al.   ENDOCRINOLOGY

miR-375 negatively regulates porcine preadipocyte differentiation by targeting BMPR2

(2016) Siyuan Liu et al.   FEBS LETTERS

p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes

(2016) Xiaoling Yu et al.   GENE

Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

(2016) Jianing Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis

(2016) Mingjia Tan et al.   Molecular Cancer

Reciprocal Negative Regulation between EGFR and DEPTOR Plays an Important Role in the Progression of Lung Adenocarcinoma

(2016) X. Zhou et al.   MOLECULAR CANCER RESEARCH

Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition

(2016) Ian Damerill et al.   MOLECULAR ENDOCRINOLOGY

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

(2016) Vanessa S. Rodrik-Outmezguine et al.   NATURE

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia

(2016) Y Hu et al.   ONCOGENE

DEPTORpromoter genetic variants and insulin resistance in obese children and adolescents

(2016) Jernej Kovač et al.   PEDIATRIC DIABETES

Genetics of long-term treatment outcome in bipolar disorder

(2016) Chiara Fabbri et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Is REDD1 a Metabolic Éminence Grise ?

(2016) Christopher Lipina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

(2016) Mélissa Carbonneau et al.   Nature Communications

DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase

(2016) Kalanghad Puthankalam Srinivas et al.   Oncotarget

Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation

(2016) Mengmeng Cheng et al.   Oncotarget

DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis

(2016) Yan-Mei Ji et al.   Oncotarget

Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells

(2016) Valeria Catena et al.   Oncotarget

PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639

(2016) Hae-In Song et al.   Scientific Reports

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

(2016) Blanka Kucejova et al.   Cell Reports

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

(2016) Alexandre Caron et al.   Molecular Metabolism

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

Evolving Perspectives of mTOR Complexes in Immunity and Transplantation

(2015) D. Fantus et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

State of the art paper Sulfonylureas and their use in clinical practice

(2015) Daniele Sola et al.   Archives of Medical Science

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

(2015) Fu-Zheng Wei et al.   Autophagy

DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells

(2015) Akio Obara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior

(2015) Verena Albert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neural Control of Energy Balance: Translating Circuits to Therapies

(2015) Laurent Gautron et al.   CELL

Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

(2015) A. Desantis et al.   EMBO JOURNAL

The Role of Hypothalamic mTORC1 Signaling in Insulin Regulation of Food Intake, Body Weight, and Sympathetic Nerve Activity in Male Mice

(2015) Kenjiro Muta et al.   ENDOCRINOLOGY

The Endosomal Sorting Complex Required for Transport Pathway Mediates Chemokine Receptor CXCR4-promoted Lysosomal Degradation of the Mammalian Target of Rapamycin Antagonist DEPTOR

(2015) Rita Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen receptor functions as a negative transcriptional regulator of DEPTOR, mTOR inhibitor

(2015) Yuichiro Kanno et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway

(2015) Niyati Malkani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid

(2015) Mee-Sup Yoon et al.   MOLECULAR CELL

Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion

(2015) Greg M. Delgoffe et al.   MOLECULAR IMMUNOLOGY

Glucocorticoid receptor ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways

(2015) Puneet Singh et al.   Obesity

mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

(2015) N Komatsu et al.   ONCOGENE

Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation

(2015) LAN CHEN et al.   ONCOLOGY REPORTS

High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma

(2015) Xu Wu et al.   OncoTargets and Therapy

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

(2015) Arindam P. Ghosh et al.   Oncotarget

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

(2015) Mark A. Smith et al.   Cell Reports

mTOR Links Environmental Signals to T Cell Fate Decisions

(2015) Nicole M. Chapman et al.   Frontiers in Immunology

Deptor Enhances Triple-Negative Breast Cancer Metastasis and Chemoresistance through Coupling to Survivin Expression

(2015) Jenny G. Parvani et al.   NEOPLASIA

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome

(2015) Rebecca L. Wilson et al.   PLoS One

DEPTOR has growth suppression activity against pancreatic cancer cells

(2015) Hua Li et al.   Oncotarget

Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application

(2015) Yongchao Zhao et al.   NEOPLASIA

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

(2014) Manuela Antonioli et al.   DEVELOPMENTAL CELL

The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity

(2014) Zhuo-Xian Meng et al.   DIABETES

Signals and pathways controlling regulatory T cells

(2014) Alexandria Huynh et al.   IMMUNOLOGICAL REVIEWS

Elucidating the role of DEPTOR in Alzheimer’s disease

(2014) JULIE DAVIES et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

DEPTOR Is a Stemness Factor That Regulates Pluripotency of Embryonic Stem Cells

(2014) Pooja Agrawal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis

(2014) Hua Li et al.   JOURNAL OF CLINICAL INVESTIGATION

DEP domain-containing mTOR-interacting protein in the rat brain: Distribution of expression and potential implication

(2014) Alexandre Caron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2

(2014) Chen Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD40-Induced Signaling in Human Endothelial Cells Results in mTORC2- and Akt-Dependent Expression of Vascular Endothelial Growth Factor In Vitro and In Vivo

(2014) O. Dormond et al.   JOURNAL OF IMMUNOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity

(2014) Elizabeth C Martin et al.   Molecular Cancer

Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance

(2014) E. Rozengurt et al.   MOLECULAR CANCER THERAPEUTICS

DEP domains: structurally similar but functionally different

(2014) Sarah V. Consonni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression

(2014) Falguni Das et al.   PLoS One

A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondriacristaeand ER contacts in the postprandial liver

(2014) Aditi Sood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

(2014) M. D. Dennis et al.   Science Signaling

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

(2014) B. C. Grabiner et al.   Cancer Discovery

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

(2014) Heidi E. Kocalis et al.   Molecular Metabolism

DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses

(2013) S. Bruneau et al.   BLOOD

mTOR and lymphocyte metabolism

(2013) Hu Zeng et al.   CURRENT OPINION IN IMMUNOLOGY

Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1

(2013) Weizhen Zhang et al.   EXPERIMENTAL PHYSIOLOGY

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

(2013) Mats I. Nilsson et al.   FASEB JOURNAL

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

The emerging role of miR-375 in cancer

(2013) Jun-Wei Yan et al.   INTERNATIONAL JOURNAL OF CANCER

Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro

(2013) HAORAN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Transforming Growth Factor β Integrates Smad 3 to Mechanistic Target of Rapamycin Complexes to Arrest Deptor Abundance for Glomerular Mesangial Cell Hypertrophy

(2013) Falguni Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells

(2013) Chen Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis

(2013) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of DEPTOR inhibits cell proliferation and increases chemosensitivity to melphalan in human multiple myeloma RPMI-8226 cells via inhibiting PI3K/AKT activity

(2013) Hao-Ran Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Toll-like receptors and liver disease

(2013) Vivek Kesar et al.   LIVER INTERNATIONAL

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

(2013) Darko Stevanovic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation

(2013) Zhuo-Xian Meng et al.   NATURE MEDICINE

Circumventricular organs: Targets for integration of circulating fluid and energy balance signals?

(2013) Andrea Mimee et al.   PHYSIOLOGY & BEHAVIOR

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

DEPTOR ubiquitination and destruction by SCFβ-TrCP

(2012) Zhiwei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells

(2012) Zhongguang Luo et al.   Autophagy

BMK1 Kinase Suppresses Epithelial-Mesenchymal Transition through the Akt/GSK3  Signaling Pathway

(2012) R. Chen et al.   CANCER RESEARCH

GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

(2012) Dong Kong et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

(2012) Mathieu Laplante et al.   Cell Metabolism

Unknown

(2012) Chia-Hung Yen et al.   MOLECULAR MEDICINE

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Global obesity: trends, risk factors and policy implications

(2012) Vasanti S. Malik et al.   Nature Reviews Endocrinology

Regulated in Development and DNA Damage Responses -1 (REDD1) Protein Contributes to Insulin Signaling Pathway in Adipocytes

(2012) Claire Regazzetti et al.   PLoS One

Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway

(2012) Caroline André et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

Molecular and biochemical characterization of a new alkaline active multidomain xylanase from alkaline wastewater sludge

(2012) Yanyu Zhao et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

(2012) Y Zhao et al.   Cell Death & Disease

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

(2012) Sarah Bruneau et al.   Frontiers in Immunology

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Insulin effects in muscle and adipose tissue

(2011) George Dimitriadis et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Metabolic Sensing and the Brain: Who, What, Where, and How?

(2011) Barry E. Levin et al.   ENDOCRINOLOGY

mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel

(2011) Ming Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Purification and biochemical characterization of a secreted group IIA chicken intestinal phospholipase A2

(2011) Aida Karray et al.   Lipids in Health and Disease

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

(2011) Shanshan Duan et al.   MOLECULAR CELL

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

Unknown

(2011) Abid Kazi et al.   MOLECULAR MEDICINE

Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma

(2011) Zhonghua Tang   Molecular Medicine Reports

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Epithelial microRNAs regulate gut mucosal immunity via epithelium–T cell crosstalk

(2011) Moshe Biton et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

(2011) Heidi L. Kenerson et al.   PLoS One

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

(2010) Kathleen G. Mountjoy   BIOCHEMICAL JOURNAL

PDZ domains and their binding partners: structure, specificity, and modification

(2010) Ho-Jin Lee et al.   Cell Communication and Signaling

Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling

(2010) Thomas S. Lisse et al.   FASEB JOURNAL

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans

(2010) James A. Timmons et al.   JOURNAL OF APPLIED PHYSIOLOGY

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci

(2010) Zala Prevoršek et al.   MAMMALIAN GENOME

SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

(2010) Ki Woo Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss

(2009) Yong Wu et al.   ENDOCRINOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR

(2009) Alexandros Tzatsos   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway

(2009) Francisco Altamirano et al.   JOURNAL OF ENDOCRINOLOGY

Effect of autophagy on multiple myeloma cell viability

(2009) B. Hoang et al.   MOLECULAR CANCER THERAPEUTICS

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity

(2009) Daniela Cota   PHYSIOLOGY & BEHAVIOR

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

(2008) Clémence Blouet et al.   Cell Metabolism

miR-375 Targets 3'-Phosphoinositide-Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic  -Cells

(2008) A. El Ouaamari et al.   DIABETES

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE

Polyphenols as Potential Inhibitors of Amyloid Aggregation and Toxicity:Possible Significance to Alzheimers Disease

(2008) S. Bastianetto et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA