Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
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Title
Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
Authors
Keywords
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Journal
Science Signaling
Volume 5, Issue 217, Pages ra24-ra24
Publisher
American Association for the Advancement of Science (AAAS)
Online
2012-03-28
DOI
10.1126/scisignal.2002739
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Note: Only part of the references are listed.- Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress
- (2011) Shukie Ng et al. Autophagy
- Transcriptional Control of Cellular Metabolism by mTOR Signaling
- (2011) J. L. Yecies et al. CANCER RESEARCH
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
- (2011) Jessica L. Yecies et al. Cell Metabolism
- Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease
- (2011) Mark J. Czaja GASTROENTEROLOGY
- The dynamic nature of autophagy in cancer
- (2011) A. C. Kimmelman GENES & DEVELOPMENT
- Autophagy-deficient mice develop multiple liver tumors
- (2011) A. Takamura et al. GENES & DEVELOPMENT
- Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
- (2011) Yoshihiro Inami et al. JOURNAL OF CELL BIOLOGY
- mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
- (2011) Ken Inoki et al. JOURNAL OF CLINICAL INVESTIGATION
- m-TOR inhibitors: What role in liver transplantation?
- (2011) Toshiyasu Kawahara et al. JOURNAL OF HEPATOLOGY
- Obesity, inflammation, and liver cancer
- (2011) Beicheng Sun et al. JOURNAL OF HEPATOLOGY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- High-resolution characterization of a hepatocellular carcinoma genome
- (2011) Yasushi Totoki et al. NATURE GENETICS
- NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
- (2011) Tom Luedde et al. Nature Reviews Gastroenterology & Hepatology
- Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
- (2011) J. Goto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
- (2011) A. Parkhitko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation
- (2010) Guobin He et al. CANCER CELL
- Hepatitis B and C virus hepatocarcinogenesis: Lessons learned and future challenges
- (2010) Michael J. Bouchard et al. CANCER LETTERS
- Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
- (2010) Eek Joong Park et al. CELL
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
- (2010) Gökhan S. Hotamisligil CELL
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- NF-κB and STAT3 – key players in liver inflammation and cancer
- (2010) Guobin He et al. CELL RESEARCH
- Role of autophagy in suppression of inflammation and cancer
- (2010) Eileen White et al. CURRENT OPINION IN CELL BIOLOGY
- Expansion of Hepatic Tumor Progenitor Cells in Pten-Null Mice Requires Liver Injury and Is Reversed by Loss of AKT2
- (2010) Vivian A. Galicia et al. GASTROENTEROLOGY
- Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
- (2010) S. Benhamouche et al. GENES & DEVELOPMENT
- Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
- (2010) Brad Q. Starley et al. HEPATOLOGY
- Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR
- (2010) Lu Peng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endoplasmic reticulum stress in liver disease
- (2010) Harmeet Malhi et al. JOURNAL OF HEPATOLOGY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
- (2010) Shomit Sengupta et al. NATURE
- The role of signaling pathways in the development and treatment of hepatocellular carcinoma
- (2010) S Whittaker et al. ONCOGENE
- Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
- (2010) H. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
- (2010) L. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy and Metabolism
- (2010) J. D. Rabinowitz et al. SCIENCE
- Hepatocellular Carcinoma: Epidemiology, Surveillance, and Diagnosis
- (2010) Morris Sherman SEMINARS IN LIVER DISEASE
- Critical roles for the TSC-mTOR pathway in β-cell function
- (2009) Hiroyuki Mori et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma
- (2009) Johannes Haybaeck et al. CANCER CELL
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- Critical Role for Hypothalamic mTOR Activity in Energy Balance
- (2009) Hiroyuki Mori et al. Cell Metabolism
- TOR-dependent control of autophagy: biting the hand that feeds
- (2009) Thomas P Neufeld CURRENT OPINION IN CELL BIOLOGY
- mTOR inhibitors for hepatocellular cancer: a forward-moving target
- (2009) Gerhard Treiber Expert Review of Anticancer Therapy
- Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner
- (2009) A. Di Nardo et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma
- (2009) Hideo A. Baba et al. LIVER INTERNATIONAL
- The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma
- (2009) Ledu Zhou et al. MEDICAL ONCOLOGY
- A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- Common corruption of the mTOR signaling network in human tumors
- (2009) S Menon et al. ONCOGENE
- The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
- (2008) Jingxiang Huang et al. BIOCHEMICAL JOURNAL
- Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
- (2008) Umut Ozcan et al. MOLECULAR CELL
- Disruption of Tsc2 in pancreatic cells induces cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
- (2008) L. Rachdi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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