The Endosomal Sorting Complex Required for Transport Pathway Mediates Chemokine Receptor CXCR4-promoted Lysosomal Degradation of the Mammalian Target of Rapamycin Antagonist DEPTOR

Gβγ interacts with mTOR and promotes its activation

(2014) Evelyn Robles-Molina et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4

(2014) Justine Holleman et al.   MOLECULAR BIOLOGY OF THE CELL

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

(2013) Aaron Ciechanover   BIOORGANIC & MEDICINAL CHEMISTRY

Endocytic trafficking of chemokine receptors

(2013) Adriano Marchese   CURRENT OPINION IN CELL BIOLOGY

Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic

(2013) Camilla Raiborg et al.   FEBS Journal

Binding to Any ESCRT Can Mediate Ubiquitin-Independent Cargo Sorting

(2013) Shrawan Kumar Mageswaran et al.   TRAFFIC

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

The Inhibitory G Protein Gi Identified as Pertussis Toxin-Catalyzed ADP-Ribosylation

(2012) Toshiaki Katada   BIOLOGICAL & PHARMACEUTICAL BULLETIN

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling

(2012) Adriano Marchese et al.   CELLULAR SIGNALLING

Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation

(2012) Michael J. Clague et al.   DEVELOPMENTAL CELL

Novel Roles for the E3 Ubiquitin Ligase Atrophin-interacting Protein 4 and Signal Transduction Adaptor Molecule 1 in G Protein-coupled Receptor Signaling

(2012) Rohit Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain

(2012) V. H. Lobert et al.   JOURNAL OF CELL SCIENCE

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Presenilin Deficiency or Lysosomal Inhibition Enhances Wnt Signaling through Relocalization of GSK3 to the Late-Endosomal Compartment

(2012) Radek Dobrowolski et al.   Cell Reports

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic

(2011) James H. Hurley et al.   Annual Review of Biophysics

UBAP1 Is a Component of an Endosome-Specific ESCRT-I Complex that Is Essential for MVB Sorting

(2011) Flavia Stefani et al.   CURRENT BIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

(2011) Shanshan Duan et al.   MOLECULAR CELL

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

(2011) Radek Dobrowolski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cargo-Dependent Degradation of ESCRT-I as a Feedback Mechanism to Modulate Endosomal Sorting

(2011) Lene Malerød et al.   TRAFFIC

How Ubiquitin Functions with ESCRTs

(2011) S. Brookhart Shields et al.   TRAFFIC

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Membrane Budding

(2010) James H. Hurley et al.   CELL

Role of Cardiac Myocyte CXCR4 Expression in Development and Left Ventricular Remodeling After Acute Myocardial Infarction

(2010) Udit Agarwal et al.   CIRCULATION RESEARCH

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Early Endosomal Antigen 1 (EEA1) Is an Obligate Scaffold for Angiotensin II-induced, PKC-α-dependent Akt Activation in Endosomes

(2010) Rafal Robert Nazarewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions

(2010) C. Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

Role of Ubiquitination in Endocytic Trafficking of G-Protein-Coupled Receptors

(2010) James N. Hislop et al.   TRAFFIC

The role of ESCRT proteins in attenuation of cell signalling

(2009) Lina M. Rodahl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The delivery of endocytosed cargo to lysosomes: Figure 1

(2009) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

(2009) Anne Simonsen et al.   JOURNAL OF CELL BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag

(2008) Rajeshwari R Valiathan et al.   Virology Journal