Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance

(2016) Alexandre Caron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Melanocortin-4 receptor–regulated energy homeostasis

(2016) Michael J Krashes et al.   NATURE NEUROSCIENCE

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

(2016) Peter Kühnen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity Impairs the Action of the Neuroendocrine Ghrelin System

(2016) Jeffrey M. Zigman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

(2016) Damien Lanfray et al.   eLife

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

(2016) Alexandre Caron et al.   Molecular Metabolism

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior

(2015) Verena Albert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neural Control of Energy Balance: Translating Circuits to Therapies

(2015) Laurent Gautron et al.   CELL

Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons

(2015) Maria Fernanda A. Fernandes et al.   Cell Metabolism

The Role of Hypothalamic mTORC1 Signaling in Insulin Regulation of Food Intake, Body Weight, and Sympathetic Nerve Activity in Male Mice

(2015) Kenjiro Muta et al.   ENDOCRINOLOGY

In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis

(2015) Sébastien M. Labbé et al.   FASEB JOURNAL

Being impulsive and obese increases susceptibility to speeded detection of high-calorie foods.

(2015) Peggy Bongers et al.   HEALTH PSYCHOLOGY

RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

(2015) Kong Y. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ghrelin Signalling on Food Reward: A Salient Link Between the Gut and the Mesolimbic System

(2015) M. Perello et al.   JOURNAL OF NEUROENDOCRINOLOGY

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Cognitive and autonomic determinants of energy homeostasis in obesity

(2015) Denis Richard   Nature Reviews Endocrinology

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

(2015) Mark A. Smith et al.   Cell Reports

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

The medial preoptic nucleus as a site of the thermogenic and metabolic actions of melanotan II in male rats

(2014) Boris Monge-Roffarello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The hypothalamic arcuate nucleus and the control of peripheral substrates

(2014) Aurélie Joly-Amado et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity

(2014) Zhuo-Xian Meng et al.   DIABETES

The PVH as a Site of CB1-Mediated Stimulation of Thermogenesis by MC4R Agonism in Male Rats

(2014) Boris Monge-Roffarello et al.   ENDOCRINOLOGY

Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

(2014) Denis P. Blondin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DEP domain-containing mTOR-interacting protein in the rat brain: Distribution of expression and potential implication

(2014) Alexandre Caron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Brown adipose tissue and its therapeutic potential

(2014) M. E. Lidell et al.   JOURNAL OF INTERNAL MEDICINE

Influence of mTOR in energy and metabolic homeostasis

(2014) Magalie Haissaguerre et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Heritability: The family roots of obesity

(2014) Cassandra Willyard   NATURE

MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

(2014) B. P. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

(2014) Heidi E. Kocalis et al.   Molecular Metabolism

Functional Organization of Neuronal and Humoral Signals Regulating Feeding Behavior

(2013) Gary J. Schwartz et al.   Annual Review of Nutrition

Beyond the Sympathetic Tone: The New Brown Fat Activators

(2013) Francesc Villarroya et al.   Cell Metabolism

Metabolic Pitfalls of CNS Cre-Based Technology

(2013) Erika Harno et al.   Cell Metabolism

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis

(2013) Anthony P Coll et al.   CURRENT OPINION IN PHARMACOLOGY

Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats

(2013) Dejan M. Nesic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain

(2013) Daniel Lindberg et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance

(2013) Marc Schneeberger et al.   JOURNAL OF ENDOCRINOLOGY

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

(2013) Darko Stevanovic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetic identification of a neural circuit that suppresses appetite

(2013) Matthew E. Carter et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation

(2013) Zhuo-Xian Meng et al.   NATURE MEDICINE

Brown adipose tissue as an anti-obesity tissue in humans

(2013) K. Chechi et al.   Obesity Reviews

Understanding the brown adipocyte as a contributor to energy homeostasis

(2013) Kanta Chechi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

(2013) Marcelo O. Dietrich et al.   TRENDS IN NEUROSCIENCES

Feelings about food: the ventral tegmental area in food reward and emotional eating

(2013) Frank J. Meye et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of insulin on excitatory synaptic transmission onto dopamine neurons of the ventral tegmental area in a mouse model of hyperinsulinemia

(2013) S Liu et al.   Nutrition & Diabetes

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

The Role of Ghrelin in Reward-Based Eating

(2012) Mario Perelló et al.   BIOLOGICAL PSYCHIATRY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

(2012) Mathieu Laplante et al.   Cell Metabolism

Brown Adipose Tissue

(2012) Charmaine S. Tam et al.   CIRCULATION

Prader-Willi Syndrome: Obesity due to Genomic Imprinting

(2012) Merlin G. Butler   CURRENT GENOMICS

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Capricious Cre: The Devil Is in the Details

(2012) Christopher D. Morrison et al.   ENDOCRINOLOGY

Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake

(2012) Dmitry. M. Mebel et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The regulation of food intake by the gut-brain axis: implications for obesity

(2012) S S Hussain et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXO1 in the ventromedial hypothalamus regulates energy balance

(2012) Ki Woo Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH

(2012) Clement C. Cheung et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Unknown

(2012) Chia-Hung Yen et al.   MOLECULAR MEDICINE

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

Neurobehavioural correlates of body mass index and eating behaviours in adults: A systematic review

(2012) Uku Vainik et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Obesity and addiction: neurobiological overlaps

(2012) N. D. Volkow et al.   Obesity Reviews

Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies

(2012) D.W. Tang et al.   PHYSIOLOGY & BEHAVIOR

Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway

(2012) Caroline André et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Hypothalamic dysfunction in obesity

(2012) Lynda M. Williams   PROCEEDINGS OF THE NUTRITION SOCIETY

Functional brain imaging of appetite

(2012) Alain Dagher   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age

(2012) Merly C. Vogt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Central nervous control of energy and glucose balance: focus on the central melanocortin system

(2011) Yong Xu et al.   Annals of the New York Academy of Sciences

Melanocortin control of energy balance: evidence from rodent models

(2011) Bart C. De Jonghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An emerging role for TOR signaling in mammalian tissue and stem cell physiology

(2011) Ryan C. Russell et al.   DEVELOPMENT

Insulin sensitivity of the human brain

(2011) Caroline Ketterer et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Insulin effects in muscle and adipose tissue

(2011) George Dimitriadis et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Metabolic Sensing and the Brain: Who, What, Where, and How?

(2011) Barry E. Levin et al.   ENDOCRINOLOGY

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

(2011) Qi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sixteen years and counting: an update on leptin in energy balance

(2011) Laurent Gautron et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of the central ghrelin system in reward from food and chemical drugs

(2011) Suzanne L. Dickson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

(2011) Tim Klöckener et al.   NATURE NEUROSCIENCE

Leptin regulates the reward value of nutrient

(2011) Ana I Domingos et al.   NATURE NEUROSCIENCE

GLP-1 and energy balance: an integrated model of short-term and long-term control

(2011) Jason G. Barrera et al.   Nature Reviews Endocrinology

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Dysregulation of brain reward systems in eating disorders: Neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa

(2011) Nicole M. Avena et al.   NEUROPHARMACOLOGY

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Central Nervous System Nutrient Signaling: The Regulation of Energy Balance and the Future of Dietary Therapies

(2010) M.A. Stefater et al.   Annual Review of Nutrition

The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders

(2010) Kent C. Berridge et al.   BRAIN RESEARCH

PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis

(2010) Yong Xu et al.   Cell Metabolism

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

A Treasure Trove of Hypothalamic Neurocircuitries Governing Body Weight Homeostasis

(2010) Claudia R. Vianna et al.   ENDOCRINOLOGY

Determinants of brown adipocyte development and thermogenesis

(2010) D Richard et al.   INTERNATIONAL JOURNAL OF OBESITY

Sympathetic and sensory innervation of brown adipose tissue

(2010) T J Bartness et al.   INTERNATIONAL JOURNAL OF OBESITY

Pathogenesis of Insulin Resistance in Skeletal Muscle

(2010) Muhammad A. Abdul-Ghani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats

(2010) Maura L. Perry et al.   JOURNAL OF NEUROCHEMISTRY

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

Executive Cognitive Function and Food Intake in Children

(2010) Nathaniel R. Riggs et al.   JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR

SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

(2010) Ki Woo Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin

(2010) M. Ghamari-Langroudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Parabrachial Coding of Sapid Sucrose:

(2009) Andras Hajnal et al.   Annals of the New York Academy of Sciences

Hypothalamic nutrient sensing in the control of energy homeostasis

(2009) Clémence Blouet et al.   BEHAVIOURAL BRAIN RESEARCH

The brain endocannabinoid system in the regulation of energy balance

(2009) Denis Richard et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

The neurobiology of appetite: hunger as addiction

(2009) A Dagher   INTERNATIONAL JOURNAL OF OBESITY

Reward systems and food intake: role of opioids

(2009) B A Gosnell et al.   INTERNATIONAL JOURNAL OF OBESITY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

(2009) A. Sainsbury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

The role of transcriptional regulators in central control of appetite and body weight

(2009) Roberto Coppari et al.   Nature Reviews Endocrinology

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders

(2009) Kent C. Berridge   PHYSIOLOGY & BEHAVIOR

Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity

(2009) Daniela Cota   PHYSIOLOGY & BEHAVIOR

The endocannabinoid system in brain reward processes

(2008) M Solinas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

(2008) Clémence Blouet et al.   Cell Metabolism

Protein, amino acids and the control of food intake

(2008) Mylène Potier et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome

(2008) Nathan C. Bingham et al.   ENDOCRINOLOGY

Central Control of Body Weight and Appetite

(2008) Stephen C. Woods et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Monitoring FoxO1 Localization in Chemically Identified Neurons

(2008) M. Fukuda et al.   JOURNAL OF NEUROSCIENCE

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY

Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis

(2008) William A. Carlezon et al.   NEUROPHARMACOLOGY

Brain circuits regulating energy homeostasis

(2008) Alfonso Abizaid et al.   REGULATORY PEPTIDES