- Home
- Publications
- Publication Search
- Publication Details
Title
mTOR Links Environmental Signals to T Cell Fate Decisions
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 5, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-01-21
DOI
10.3389/fimmu.2014.00686
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
- (2014) Min Peng et al. CELL
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
- (2014) Mako Nakaya et al. IMMUNITY
- Amino Acids Fuel T Cell-Mediated Inflammation
- (2014) Maya C. Poffenberger et al. IMMUNITY
- The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
- (2014) Matthew M. Staron et al. IMMUNITY
- Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)
- (2014) Han C. Dan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
- (2014) Julio Gomez-Rodriguez et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Defects in Skin T Cell Function Contribute to Delayed Wound Repair in Rapamycin-Treated Mice
- (2014) R. E. Mills et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Discrete Functions of mTOR Signaling in Invariant NKT Cell Development and NKT17 Fate Decision
- (2014) Jun Wei et al. JOURNAL OF IMMUNOLOGY
- Mammalian Target of Rapamycin Complex 2 Modulates TCR Processing and Surface Expression during Thymocyte Development
- (2014) P.-C. Chou et al. JOURNAL OF IMMUNOLOGY
- Mammalian Target of Rapamycin Complex 1 Orchestrates Invariant NKT Cell Differentiation and Effector Function
- (2014) Lianjun Zhang et al. JOURNAL OF IMMUNOLOGY
- Mammalian Target of Rapamycin Complex 2 Regulates Invariant NKT Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger
- (2014) Nicolas Prevot et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Generation of Effector Cells That Localize to Mucosal Tissues and Form Resident Memory CD8 T Cells Is Controlled by mTOR
- (2014) Ryan T. Sowell et al. JOURNAL OF IMMUNOLOGY
- Tuberous Sclerosis 1 Promotes Invariant NKT Cell Anergy and Inhibits Invariant NKT Cell-Mediated Antitumor Immunity
- (2014) J. Wu et al. JOURNAL OF IMMUNOLOGY
- IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival
- (2014) K E Webster et al. Mucosal Immunology
- A central role for Notch in effector CD8+ T cell differentiation
- (2014) Ronald A Backer et al. NATURE IMMUNOLOGY
- Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells
- (2014) T. Hoshii et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development
- (2014) H. Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function
- (2014) J. Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs
- (2014) S. Shrestha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T Cell Receptor-Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10
- (2014) K. S. Hamilton et al. Science Signaling
- HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance
- (2014) Huai-Chia Chuang et al. Nature Communications
- Mucosal-Associated Invariant T-Cells: New Players in Anti-Bacterial Immunity
- (2014) James E. Ussher et al. Frontiers in Immunology
- mTOR and lymphocyte metabolism
- (2013) Hu Zeng et al. CURRENT OPINION IN IMMUNOLOGY
- T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
- (2013) Kai Yang et al. IMMUNITY
- Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity
- (2013) Alexey Berezhnoy et al. JOURNAL OF CLINICAL INVESTIGATION
- TSC1 regulates the balance between effector and regulatory T cells
- (2013) Yoon Park et al. JOURNAL OF CLINICAL INVESTIGATION
- The SLC3 and SLC7 families of amino acid transporters
- (2013) Dimitrios Fotiadis et al. MOLECULAR ASPECTS OF MEDICINE
- Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
- (2013) Chuan Wu et al. NATURE
- Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
- (2013) Markus Kleinewietfeld et al. NATURE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells
- (2013) You Jeong Lee et al. NATURE IMMUNOLOGY
- NF-κB control of T cell development
- (2013) Steve Gerondakis et al. NATURE IMMUNOLOGY
- Regulatory T cell proliferative potential is impaired in human autoimmune disease
- (2013) Fortunata Carbone et al. NATURE MEDICINE
- Amino acid signalling upstream of mTOR
- (2013) Jenna L. Jewell et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Targeting co-stimulatory pathways: transplantation and autoimmunity
- (2013) Mandy L. Ford et al. Nature Reviews Nephrology
- mTOR and metabolic pathways in T cell quiescence and functional activation
- (2013) Kai Yang et al. SEMINARS IN IMMUNOLOGY
- Regulatory T Cells and Immune Tolerance in the Intestine
- (2013) O. J. Harrison et al. Cold Spring Harbor Perspectives in Biology
- Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies
- (2013) Stephen R Daley et al. eLife
- Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features
- (2013) Sari Lehtimäki et al. Frontiers in Immunology
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
- (2012) Keunwook Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells
- (2012) David K. Finlay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Metabolic checkpoints in activated T cells
- (2012) Ruoning Wang et al. NATURE IMMUNOLOGY
- T cell homing to epithelial barriers in allergic disease
- (2012) Sabina A Islam et al. NATURE MEDICINE
- TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice
- (2012) Lianjun Zhang et al. PLoS One
- Amino acids and mTORC1: from lysosomes to disease
- (2012) Alejo Efeyan et al. TRENDS IN MOLECULAR MEDICINE
- PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ
- (2012) Yutaka Kurebayashi et al. Cell Reports
- Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques
- (2011) A. P. Turner et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Negative regulation of mTOR activation by diacylglycerol kinases
- (2011) B. K. Gorentla et al. BLOOD
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Rapamycin-sensitive signals control TCR/CD28-drivenIfng,Il4andFoxp3transcription and promoter region methylation
- (2011) Romana Tomasoni et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Regulation of T-cell survival and mitochondrial homeostasis by TSC1
- (2011) Thomas F. O'Brien et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells
- (2011) E. Tresoldi et al. HAEMATOLOGICA
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism
- (2011) Andrew N. Macintyre et al. IMMUNITY
- A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity
- (2011) Qingsheng Li et al. IMMUNITY
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism
- (2011) Nancie J. MacIver et al. JOURNAL OF IMMUNOLOGY
- OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling
- (2011) T. So et al. JOURNAL OF IMMUNOLOGY
- The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
- (2011) Q. Wu et al. JOURNAL OF IMMUNOLOGY
- Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity
- (2011) J. Cantor et al. JOURNAL OF IMMUNOLOGY
- Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
- (2011) Jonathan Sprent et al. NATURE IMMUNOLOGY
- The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
- (2011) Kai Yang et al. NATURE IMMUNOLOGY
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- (2011) Greg M Delgoffe et al. NATURE IMMUNOLOGY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells
- (2011) Tatiana N. Golovina et al. PLoS One
- Suppression of leukemia development caused by PTEN loss
- (2011) W. Guo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor
- (2011) C.-H. Chen et al. Science Signaling
- Differentiation of Effector CD4 T Cell Populations
- (2010) Jinfang Zhu et al. Annual Review of Immunology
- Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
- (2010) Haishan Li et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
- (2010) Claudio Procaccini et al. IMMUNITY
- Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways
- (2010) Keunwook Lee et al. IMMUNITY
- The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation
- (2010) Muhammet F. Gulen et al. IMMUNITY
- The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
- (2010) Rajesh R. Rao et al. IMMUNITY
- Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
- (2010) Xiaohe Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
- (2010) Guangwei Liu et al. NATURE IMMUNOLOGY
- The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
- (2009) Yonghao Cao et al. CELL RESEARCH
- LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
- (2009) Peter Tamás et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
- (2009) Greg M. Delgoffe et al. IMMUNITY
- Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
- (2009) David K. Finlay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
- (2009) Loise M. Francisco et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes
- (2009) Noemi Cruz-Orcutt et al. MOLECULAR IMMUNOLOGY
- Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation
- (2009) Greg M. Delgoffe et al. MOLECULAR IMMUNOLOGY
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- mTOR regulates memory CD8 T-cell differentiation
- (2009) Koichi Araki et al. NATURE
- The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
- (2009) Guangwei Liu et al. NATURE IMMUNOLOGY
- The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
- (2009) Meghan A Koch et al. NATURE IMMUNOLOGY
- Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
- (2009) Yann M Kerdiles et al. NATURE IMMUNOLOGY
- Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs
- (2009) K. Bocian et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Infectious tolerance via the consumption of essential amino acids and mTOR signaling
- (2009) S. P. Cobbold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
- (2008) Alice Mayer et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
- (2008) Johnthomas Kang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
- (2008) Linda V Sinclair et al. NATURE IMMUNOLOGY
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory T Cells: Mechanisms of Differentiation and Function
- (2007) Steven Z. Josefowicz et al. Annual Review of Immunology
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started