Signals and pathways controlling regulatory T cells

Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation

(2014) S. K. Chauhan et al.   JOURNAL OF IMMUNOLOGY

CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

(2014) T. N. Golovina et al.   JOURNAL OF IMMUNOLOGY

FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase

(2014) S. Fabre et al.   JOURNAL OF IMMUNOLOGY

CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message

(2014) C. Nazarov-Stoica et al.   JOURNAL OF IMMUNOLOGY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

(2013) Kevin Goudy et al.   CLINICAL IMMUNOLOGY

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

(2013) Jiyeon S Kim et al.   NATURE IMMUNOLOGY

Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and Protein kinase B AKT signaling

(2013) L. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant ArteriosclerosisIn Vivo

(2012) J. Hester et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP

(2012) Michelle M. Collazo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth

(2012) Wiebke Hansen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses

(2012) C. Procaccini et al.   JOURNAL OF IMMUNOLOGY

Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function

(2012) G. Garg et al.   JOURNAL OF IMMUNOLOGY

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intragraft Regulatory T Cells in Protocol Biopsies Retain Foxp3 Demethylation and Are Protective Biomarkers for Kidney Graft Outcome

(2011) O. Bestard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF- B-Dependent Manner

(2011) L. L. Molinero et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3+ CD4 Regulatory T Cells

(2011) George Grigoriadis et al.   PLoS One

CD4+CD25+Foxp3+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion

(2011) C. Cozzo Picca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

(2011) E. Gatza et al.   Science Translational Medicine

B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion

(2011) Maria Hinterberger et al.   Frontiers in Immunology

SHIP deficiency causes Crohn's disease-like ileitis

(2010) W. G. Kerr et al.   GUT

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

Foxo Transcription Factors Control Regulatory T Cell Development and Function

(2010) Yann M. Kerdiles et al.   IMMUNITY

The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells

(2010) Shudan Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice

(2010) Xiaohe Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD28 Facilitates the Generation of Foxp3- Cytokine Responsive Regulatory T Cell Precursors

(2010) C. W. J. Lio et al.   JOURNAL OF IMMUNOLOGY

The Role of the LAT–PLC-γ1 Interaction in T Regulatory Cell Function

(2010) Mariana I. Chuck et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD28 and c-Rel-Dependent Pathways Initiate Regulatory T Cell Development

(2010) K. B. Vang et al.   JOURNAL OF IMMUNOLOGY

Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

(2010) S. Tanaka et al.   JOURNAL OF IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

(2010) Weiming Ouyang et al.   NATURE IMMUNOLOGY

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Regulatory T Cells in Kidney Allograft Infiltrates Correlate With Initial Inflammation and Graft Function

(2010) Cécile Taflin et al.   TRANSPLANTATION

SHIP limits immunoregulatory capacity in the T-cell compartment

(2009) M. M. Collazo et al.   BLOOD

T Cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T Cells

(2009) Xin Liu et al.   IMMUNITY

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

(2009) Aixin Yu et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

(2009) Lih-Yun Hsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

c-Rel is required for the development of thymic Foxp3+CD4 regulatory T cells

(2009) Iwao Isomura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CARMA1 Controls an Early Checkpoint in the Thymic Development of FoxP3+ Regulatory T Cells

(2009) L. L. Molinero et al.   JOURNAL OF IMMUNOLOGY

SHIP Regulates the Reciprocal Development of T Regulatory and Th17 Cells

(2009) N. R. Locke et al.   JOURNAL OF IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

(2009) Laura Strauss et al.   PLoS One

Impact of the TCR Signal on Regulatory T Cell Homeostasis, Function, and Trafficking

(2009) Joong Kyu Kim et al.   PLoS One

Heterogeneity of natural Foxp3+T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

(2009) Noriko Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice

(2009) Li Bian et al.   ARTHRITIS RESEARCH & THERAPY

Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery

(2009) Michael J Barnes et al.   PLOS BIOLOGY

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

(2008) Sarah E. Allan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen-specific peripheral shaping of the natural regulatory T cell population

(2008) Stephanie K. Lathrop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

(2008) Sonal Gupta et al.   MOLECULAR IMMUNOLOGY

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients

(2008) Ying Li et al.   TRANSPLANTATION