Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

(2009) Lihong Huo et al.   Cell Metabolism

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

(2009) H. V. Lin et al.   DIABETES

A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation

(2009) Robin G Lerner et al.   EMBO REPORTS

Brain-Derived Neurotrophic Factor/Tropomyosin-Related Kinase Receptor Type B Signaling Is a Downstream Effector of the Brainstem Melanocortin System in Food Intake Control

(2009) Bruno Bariohay et al.   ENDOCRINOLOGY

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

Receptors for Tumor Necrosis Factor-α Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status

(2009) Nathalie Pamir et al.   ENDOCRINOLOGY

Mechanisms of obesity and related pathology: linking immune responses to metabolic stress

(2009) Katia P. Karalis et al.   FEBS Journal

Opposite Effects of the Melanocortin-2 (MC2) Receptor Accessory Protein MRAP on MC2 and MC5 Receptor Dimerization and Trafficking

(2009) Julien A. Sebag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanocortin-4-Receptor Autoantibodies: A New Player in Obesity

(2009) Chandra Mohan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit

(2009) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

Hormone and glucose signalling in POMC and AgRP neurons

(2009) Bengt F. Belgardt et al.   JOURNAL OF PHYSIOLOGY-LONDON

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain

(2009) Beatrice Dubern et al.   PEDIATRIC RESEARCH

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

(2009) L. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence

(2008) C. Kay Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Regulation of hepatic PPARγ2 and lipogenic gene expression by melanocortin

(2008) Nicole J. Poritsanos et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

Novel melanocortin 4 receptor gene mutations in severely obese children

(2008) Yung Seng Lee et al.   CLINICAL ENDOCRINOLOGY

Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant

(2008) J. Krakoff et al.   DIABETES

A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome

(2008) Jencia Wong et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Energetic Responses Are Triggered by Caudal Brainstem Melanocortin Receptor Stimulation and Mediated by Local Sympathetic Effector Circuits

(2008) Karolina P. Skibicka et al.   ENDOCRINOLOGY

Sporadic mutations in melanocortin receptor 3 in morbid obese individuals

(2008) Monica Mencarelli et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion

(2008) Giovanna Leoni et al.   FASEB JOURNAL

Regions of Melanocortin 2 (MC2) Receptor Accessory Protein Necessary for Dual Topology and MC2 Receptor Trafficking and Signaling

(2008) Julien A. Sebag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Melanocortin-4 Receptor Autoantibodies in Obesity

(2008) Jean-Christophe Peter et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity

(2008) Jacob C Garza et al.   JOURNAL OF ENDOCRINOLOGY

Photoperiod Regulates Genes Encoding Melanocortin 3 and Serotonin Receptors and Secretogranins in the Dorsomedial Posterior Arcuate of the Siberian Hamster

(2008) K. N. Nilaweera et al.   JOURNAL OF NEUROENDOCRINOLOGY

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

(2008) S. Wan et al.   JOURNAL OF NEUROSCIENCE

The Melanocortin-3 Receptor Is Required for Entrainment to Meal Intake

(2008) G. M. Sutton et al.   JOURNAL OF NEUROSCIENCE

Agouti-Related Peptide and MC3/4 Receptor Agonists Both Inhibit Excitatory Hypothalamic Ventromedial Nucleus Neurons

(2008) L.-Y. Fu et al.   JOURNAL OF NEUROSCIENCE

Weak Functional Coupling of the Melanocortin-1 Receptor Expressed in Human Adipocytes

(2008) Matthias Hoch et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background

(2008) Dai Chida et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxytocin Deficiency Mediates Hyperphagic Obesity ofSim1Haploinsufficient Mice

(2008) Bassil M. Kublaoui et al.   MOLECULAR ENDOCRINOLOGY

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Association of the MC4R V103I Polymorphism With the Metabolic Syndrome: The KORA Study

(2008) Iris M. Heid et al.   Obesity

Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats

(2008) Staci D. Bilbo et al.   PSYCHONEUROENDOCRINOLOGY

Interleukin-18 and stress

(2007) Shuei Sugama et al.   BRAIN RESEARCH REVIEWS

Counterintuitive Effects of Double-Heterozygous Null Melanocortin-4 Receptor and Leptin Genes on Diet-Induced Obesity and Insulin Resistance in C57BL/6J Mice

(2007) James L. Trevaskis et al.   ENDOCRINOLOGY

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY

A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally

(2007) Gregory M. Sutton et al.   PEPTIDES