Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
Authors
Keywords
-
Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 124, Issue 2, Pages 835-846
Publisher
American Society for Clinical Investigation
Online
2014-01-15
DOI
10.1172/jci70297
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cullin-RING Ligases as Attractive Anti-cancer Targets
- (2013) Yongchao Zhao et al. CURRENT PHARMACEUTICAL DESIGN
- MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy
- (2012) Steffan T Nawrocki et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Ras Stabilization Through Aberrant Activation of Wnt/ -Catenin Signaling Promotes Intestinal Tumorigenesis
- (2012) W.-J. Jeong et al. Science Signaling
- Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis
- (2012) Y Zhao et al. Cell Death & Disease
- Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase
- (2012) Yi Sun et al. Protein & Cell
- NEDD8 Pathways in Cancer, Sine Quibus Non
- (2011) Ian R. Watson et al. CANCER CELL
- Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor
- (2011) D. Wei et al. CANCER RESEARCH
- SCF E3 Ubiquitin Ligases as Anticancer Targets
- (2011) L. Jia et al. CURRENT CANCER DRUG TARGETS
- SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation
- (2011) Mingjia Tan et al. DEVELOPMENTAL CELL
- DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy
- (2011) Yongchao Zhao et al. MOLECULAR CELL
- The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
- (2011) Daniel Schramek et al. NATURE GENETICS
- Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors
- (2011) A. T. Sasaki et al. Science Signaling
- Cancer Statistics, 2010
- (2010) A. Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Validation of SAG/RBX2/ROC2 E3 Ubiquitin Ligase as an Anticancer and Radiosensitizing Target
- (2010) L. Jia et al. CLINICAL CANCER RESEARCH
- Transduced Tat–SAG fusion protein protects against oxidative stress and brain ischemic insult
- (2010) Dae Won Kim et al. FREE RADICAL BIOLOGY AND MEDICINE
- Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells
- (2010) Mingjia Tan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
- (2010) James E. Brownell et al. MOLECULAR CELL
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- Atypical Protein Kinase C Is Required for Bronchioalveolar Stem Cell Expansion and Lung Tumorigenesis
- (2009) R. P. Regala et al. CANCER RESEARCH
- ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence
- (2009) L. Jia et al. CANCER RESEARCH
- SnapShot: F Box Proteins I
- (2009) Jeffrey R. Skaar et al. CELL
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer
- (2009) T. A. Soucy et al. CLINICAL CANCER RESEARCH
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
- (2009) Etienne Meylan et al. NATURE
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
- (2009) Michel DuPage et al. Nature Protocols
- RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27
- (2009) M. Tan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1
- (2008) Dimitris P. Xirodimas BIOCHEMICAL SOCIETY TRANSACTIONS
- Growth Inhibition and Radiosensitization of Glioblastoma and Lung Cancer Cells by Small Interfering RNA Silencing of Tumor Necrosis Factor Receptor-Associated Factor 2
- (2008) M. Zheng et al. CANCER RESEARCH
- SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27
- (2008) Hongbin He et al. CARCINOGENESIS
- Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series
- (2008) Gwénaël Rabut et al. EMBO REPORTS
- Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
- (2008) Kerby Shedden et al. NATURE MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started