Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease
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Title
Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease
Authors
Keywords
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Journal
JOURNAL OF NEUROCHEMISTRY
Volume 144, Issue 6, Pages 691-709
Publisher
Wiley
Online
2018-01-17
DOI
10.1111/jnc.14308
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Note: Only part of the references are listed.- Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease
- (2018) Chiara Milanese et al. ANTIOXIDANTS & REDOX SIGNALING
- Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
- (2018) Chao Wang et al. CURRENT OPINION IN NEUROBIOLOGY
- Health implications of sleep and circadian rhythm research in 2017
- (2018) Sabra M Abbott et al. LANCET NEUROLOGY
- Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease
- (2018) Yasuo Miki et al. NEUROBIOLOGY OF AGING
- The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein
- (2018) Michael P. Nelson et al. NEUROBIOLOGY OF DISEASE
- Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review
- (2018) Arun T Nair et al. Journal of Neurogastroenterology and Motility
- New methods for monitoring mitochondrial biogenesis and mitophagy in vitro and in vivo
- (2017) Jessica A Williams et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes
- (2017) Laura Scott et al. EXPERIMENTAL NEUROLOGY
- Fats for thoughts: An update on brain fatty acid metabolism
- (2017) Adele Romano et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice
- (2017) Niharika Amireddy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions
- (2017) Hoi-Shan Wong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal
- (2017) Shi Zhang et al. JOURNAL OF NEUROCHEMISTRY
- DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia
- (2017) Yuval Nash et al. JOURNAL OF NEUROCHEMISTRY
- Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants
- (2017) Manish Verma et al. JOURNAL OF NEUROSCIENCE
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Targeting α-Synuclein as a therapy for Parkinson's disease: The battle begins
- (2017) C. Warren Olanow et al. MOVEMENT DISORDERS
- Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome
- (2017) Erin M. Hill-Burns et al. MOVEMENT DISORDERS
- Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
- (2017) J.A. Obeso et al. MOVEMENT DISORDERS
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+dendritic cells
- (2017) Vrajesh V. Parekh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
- (2017) Hayden Weng Siong Tan et al. Nature Communications
- Using chemical biology to assess and modulate mitochondria: progress and challenges
- (2017) Angela Logan et al. Interface Focus
- O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease
- (2017) Willayat Y. Wani et al. Molecular Brain
- The Neurodegenerative Mitochondriopathies
- (2017) Russell H. Swerdlow JOURNAL OF ALZHEIMERS DISEASE
- Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
- (2017) Noriyuki Matsuda et al. Scientific Reports
- Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?
- (2016) Nathan Basisty et al. AGING CELL
- 4-Hydroxy-2-nonenal: a critical target in oxidative stress?
- (2016) Mason Breitzig et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression
- (2016) Lakshmi Galam et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7
- (2016) Bao Wang et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins
- (2016) R. Trapannone et al. BIOCHEMICAL JOURNAL
- Cardioprotective Effects of Mitochondria-Targeted Peptide SBT-20 in two Different Models of Rat Ischemia/Reperfusion
- (2016) Wangde Dai et al. CARDIOVASCULAR DRUGS AND THERAPY
- Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
- (2016) Timothy R. Sampson et al. CELL
- Cathepsin D as a therapeutic target in Alzheimer’s disease
- (2016) Fabio Di Domenico et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism
- (2016) Adam R. Wende et al. FREE RADICAL BIOLOGY AND MEDICINE
- Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism
- (2016) Saranya Ravi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
- (2016) Martin D. Brand FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ
- (2016) David M. Stucki et al. FREE RADICAL BIOLOGY AND MEDICINE
- α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly
- (2016) Takayuki Oikawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2016) Elvira Valera et al. JOURNAL OF NEUROCHEMISTRY
- ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy
- (2016) Terytty Yang Li et al. MOLECULAR CELL
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- (2016) Mária Baranyi et al. Molecular Neurodegeneration
- Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease
- (2016) Ashutosh Kumar et al. Molecular Neurodegeneration
- Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
- (2016) Nour K. Majbour et al. Molecular Neurodegeneration
- Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s Disease
- (2016) Bruno A. Benitez et al. Molecular Neurodegeneration
- miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
- (2016) Jaekwang Kim et al. Molecular Neurodegeneration
- LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
- (2016) Elisa Belluzzi et al. Molecular Neurodegeneration
- MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease
- (2016) Yan Zhou et al. Molecular Neurodegeneration
- Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology
- (2016) K. Del Tredici et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons
- (2016) Johanna Mäkelä et al. NEUROPHARMACOLOGY
- Loss of ATP13A2 impairs glycolytic function in Kufor-Rakeb syndrome patient-derived cell models
- (2016) Jin-Sung Park et al. PARKINSONISM & RELATED DISORDERS
- Mechanisms linking circadian clocks, sleep, and neurodegeneration
- (2016) Erik S. Musiek et al. SCIENCE
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity
- (2016) Yoon Kyung Jo et al. Oncotarget
- The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases
- (2016) Matthew Redmann et al. Aging and Disease
- Role of nitrite, urate and pepsin in the gastroprotective effects of saliva
- (2016) Bárbara S. Rocha et al. Redox Biology
- Metabolic, autophagic, and mitophagic activities in cancer initiation and progression
- (2016) Anita Hjelmeland et al. Biomedical Journal
- Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease
- (2015) Ziv Gan-Or et al. Autophagy
- High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation
- (2015) Sujith Dassanayaka et al. BIOCHEMICAL JOURNAL
- KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity
- (2015) Matthew Dodson et al. BIOCHEMICAL JOURNAL
- Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
- (2015) Lei Shi et al. CURRENT OPINION IN CELL BIOLOGY
- Sulforaphane protects the heart from doxorubicin-induced toxicity
- (2015) Preeti Singh et al. FREE RADICAL BIOLOGY AND MEDICINE
- The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model
- (2015) Anna J. Dare et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- A53T Human -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration
- (2015) L. Chen et al. JOURNAL OF NEUROSCIENCE
- Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
- (2015) Benjamin Dehay et al. LANCET NEUROLOGY
- Measuring In Vivo Mitophagy
- (2015) Nuo Sun et al. MOLECULAR CELL
- LRRK2 Promotes Tau Accumulation, Aggregation and Release
- (2015) Patrícia Silva Guerreiro et al. MOLECULAR NEUROBIOLOGY
- Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
- (2015) Nicola J. Rutherford et al. Molecular Neurodegeneration
- The RAB39B p.G192R mutation causes X-linked dominant Parkinson’s disease
- (2015) Ignacio F. Mata et al. Molecular Neurodegeneration
- Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease
- (2015) Seon-Heui Cha et al. Molecular Neurodegeneration
- Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
- (2015) Wei Xiang et al. Molecular Neurodegeneration
- Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
- (2015) Davide Chiasserini et al. Molecular Neurodegeneration
- Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
- (2015) Aoife P. Kiely et al. Molecular Neurodegeneration
- A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
- (2015) Brian Spencer et al. Molecular Neurodegeneration
- Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease
- (2015) Yupin Chen et al. Molecular Neurodegeneration
- Mutations in LRRK2 potentiate age-related impairment of autophagic flux
- (2015) Shamol Saha et al. Molecular Neurodegeneration
- Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells
- (2015) Giulia Ambrosi et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
- (2015) Brent J. Ryan et al. TRENDS IN BIOCHEMICAL SCIENCES
- Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney
- (2015) Peter S. Harris et al. Redox Biology
- Oxidative stress: a concept in redox biology and medicine
- (2015) Helmut Sies Redox Biology
- A novel role for 12/15-lipoxygenase in regulating autophagy
- (2015) Alwena H. Morgan et al. Redox Biology
- Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches
- (2015) Jianhua Zhang Redox Biology
- Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice
- (2015) Xi Chen et al. PLoS One
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase
- (2014) Gulcin Pekkurnaz et al. CELL
- Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
- (2014) D J Roberts et al. CELL DEATH AND DIFFERENTIATION
- The Bioenergetic Health Index: a new concept in mitochondrial translational research
- (2014) Balu K. Chacko et al. CLINICAL SCIENCE
- The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease
- (2014) Liliana Lozano et al. EXPERIMENTAL GERONTOLOGY
- Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
- (2014) Ernesto Miquel et al. FREE RADICAL BIOLOGY AND MEDICINE
- Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics
- (2014) Anna-Liisa Levonen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitophagy mechanisms and role in human diseases
- (2014) Matthew Redmann et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Inhibition of Neuronal Cell Mitochondrial Complex I with Rotenone Increases Lipid β-Oxidation, Supporting Acetyl-Coenzyme A Levels
- (2014) Andrew J. Worth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers
- (2014) Scott A. Yuzwa et al. JOURNAL OF MOLECULAR BIOLOGY
- Aldehyde dehydrogenase (ALDH) in Alzheimer’s and Parkinson’s disease
- (2014) Edna Grünblatt et al. JOURNAL OF NEURAL TRANSMISSION
- Bioenergetic adaptation in response to autophagy regulators during rotenone exposure
- (2014) Samantha Giordano et al. JOURNAL OF NEUROCHEMISTRY
- Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
- (2014) Rachel A. Gioscia-Ryan et al. JOURNAL OF PHYSIOLOGY-LONDON
- Regulation of autophagy by protein post-translational modification
- (2014) Willayat Yousuf Wani et al. LABORATORY INVESTIGATION
- Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells
- (2014) Rita Perfeito et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition
- (2014) David J. Roberts et al. MOLECULAR CELL
- Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
- (2014) Guillermo Mariño et al. MOLECULAR CELL
- Gut microbiota are related to Parkinson's disease and clinical phenotype
- (2014) Filip Scheperjans et al. MOVEMENT DISORDERS
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation
- (2014) Bin Guo et al. NATURE CELL BIOLOGY
- Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis
- (2014) Joshua K Salabei et al. Nature Protocols
- Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
- (2014) R. M. Ivatt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sleep and Circadian Rhythm Regulation in Early Parkinson Disease
- (2014) David P. Breen et al. JAMA Neurology
- A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
- (2014) Philip A. Kramer et al. Redox Biology
- Therapeutic induction of autophagy to modulate neurodegenerative disease progression
- (2013) Warren E Hochfeld et al. ACTA PHARMACOLOGICA SINICA
- Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region
- (2013) William T. Wissemann et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells
- (2013) Tanecia Mitchell et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells
- (2013) Matthew Dodson et al. Autophagy
- Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts
- (2013) Qiuli Liang et al. BIOCHEMICAL JOURNAL
- Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes
- (2013) Huajun Jin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines
- (2013) Amarjargal Dashdorj et al. BMC Medicine
- A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
- (2013) Nicholas T. Hertz et al. CELL
- The gut microbiome as novel cardio-metabolic target: the time has come!
- (2013) S. Vinje et al. EUROPEAN HEART JOURNAL
- Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons
- (2013) Gloria A. Benavides et al. FREE RADICAL BIOLOGY AND MEDICINE
- Reductive stress in young healthy individuals at risk of Alzheimer disease
- (2013) Mari-Carmen Badía et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cellular metabolic and autophagic pathways: Traffic control by redox signaling
- (2013) Matthew Dodson et al. FREE RADICAL BIOLOGY AND MEDICINE
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) Nika N. Danial et al. JOURNAL OF CHILD NEUROLOGY
- Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34
- (2013) V. V. Parekh et al. JOURNAL OF IMMUNOLOGY
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- (2013) Steven Lubbe et al. JOURNAL OF NEUROLOGY
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- (2013) A. Reeve et al. JOURNAL OF NEUROSCIENCE
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- (2013) L. Li et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies
- (2013) Adrien W. Schmid et al. MOLECULAR & CELLULAR PROTEOMICS
- Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity
- (2013) Wei Xiang et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The coming crisis: Obtaining care for the growing burden of neurodegenerative conditions
- (2013) E. R. Dorsey et al. NEUROLOGY
- Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
- (2013) David Freeman et al. PLoS One
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrially targeted compounds and their impact on cellular bioenergetics
- (2013) Colin Reily et al. Redox Biology
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- (2013) Balaraman Kalyanaraman Redox Biology
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- (2013) Jianhua Zhang Redox Biology
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- (2013) Casey L. Quinlan et al. Redox Biology
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- (2013) Samantha Giordano et al. Redox Biology
- Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
- (2013) Nady Braidy et al. Translational Neurodegeneration
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- (2012) Salvatore J. Cherra et al. AMERICAN JOURNAL OF PATHOLOGY
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- (2012) Ashlee N. Higdon et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2012) Michael H. Yan et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2012) X. Wang et al. HUMAN MOLECULAR GENETICS
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- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2012) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
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- (2012) Scott A Yuzwa et al. Nature Chemical Biology
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- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
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- (2012) Anne Grünewald et al. NEUROBIOLOGY OF AGING
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- (2012) Samantha Giordano et al. PLoS One
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- (2012) N. Jaber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2012) K. C. Luk et al. SCIENCE
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- (2012) Thomas Fritsch et al. SOUTHERN MEDICAL JOURNAL
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- (2012) D. Narendra et al. Cold Spring Harbor Perspectives in Biology
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- (2012) Yoichi Imaizumi et al. Molecular Brain
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- (2012) Félix Moruno et al. Cells
- Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes
- (2011) Ayako Makino et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease
- (2011) Terina N. Martinez et al. ANTIOXIDANTS & REDOX SIGNALING
- Systems biology of the autophagy-lysosomal pathway
- (2011) Anil G. Jegga et al. Autophagy
- Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
- (2011) Jisun Lee et al. BIOCHEMICAL JOURNAL
- Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
- (2011) Christian Hölscher BIOCHEMICAL SOCIETY TRANSACTIONS
- A deadly spread: cellular mechanisms of α-synuclein transfer
- (2011) J A Steiner et al. CELL DEATH AND DIFFERENTIATION
- 4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification
- (2011) Kristofer S. Fritz et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Rotenone, Paraquat, and Parkinson’s Disease
- (2011) Caroline M. Tanner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
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- (2011) Marianne van der Mark et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Assessing bioenergetic function in response to oxidative stress by metabolic profiling
- (2011) Brian P. Dranka et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2011) Yuangang Zhu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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- (2011) Sovan Sarkar et al. MOLECULAR CELL
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming
- (2011) C H Eng et al. ONCOGENE
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation
- (2010) Insil Kim et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Nitrate-Nitrite-Nitric Oxide Pathway
- (2010) Eddie Weitzberg et al. ANESTHESIOLOGY
- Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
- (2010) Jonathan Wills et al. EXPERIMENTAL NEUROLOGY
- Cellular effects of peptide and protein hydroperoxides
- (2010) Aldwin Suryo Rahmanto et al. FREE RADICAL BIOLOGY AND MEDICINE
- What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
- (2010) Bradford G. Hill et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
- (2010) Virginie Loeb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3
- (2010) C.-H. Lin et al. JOURNAL OF NEUROSCIENCE
- Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease
- (2010) Lonnie Schneider et al. Molecular Neurodegeneration
- The use of PET in Alzheimer disease
- (2010) Agneta Nordberg et al. Nature Reviews Neurology
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
- (2009) Mordhwaj S. Parihar et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1
- (2009) Jeff Blackinton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity
- (2009) Guangwei Liu et al. NEUROSCIENCE LETTERS
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
- (2009) Valerie Cullen et al. Molecular Brain
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Metabolic Phenotyping in Health and Disease
- (2008) Elaine Holmes et al. CELL
- Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose
- (2008) Yong Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
- (2008) Scott A Yuzwa et al. Nature Chemical Biology
- Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease
- (2008) Tanea Reed et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
- (2008) Shaik Shavali et al. NEUROSCIENCE LETTERS
- Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice
- (2008) Namakkal S. Rajasekaran et al. PHYSIOLOGICAL GENOMICS
- Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson's Disease
- (2008) Mathieu Marella et al. PLoS One
- Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
- (2008) Liyan Qiao et al. Molecular Brain
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