Article
Neurosciences
Tae-Young Ha, Yu Ree Choi, Hye Rin Noh, Seon-Heui Cha, Jae-Bong Kim, Sang Myun Park
Summary: The study demonstrates that with age, Cav-1 expression in the brain increases and significantly increases in the brain of A53T alpha-syn transgenic mice. Overexpression of Cav-1 facilitates the uptake of alpha-syn into neurons and formation of additional Lewy body-like inclusion bodies. Phosphorylation of Cav-1 at tyrosine 14 plays a crucial role in this process.
Article
Biochemistry & Molecular Biology
Mima Shikanai, Shiho Ito, Yoshiaki Nishimura, Remi Akagawa, Mitsunori Fukuda, Michisuke Yuzaki, Yo-ichi Nabeshima, Takeshi Kawauchi
Summary: Transmembrane proteins are internalized through clathrin- and caveolin-dependent endocytosis. Rab5 and Rab21, two small GTPases, are involved in regulating these pathways. However, in cortical neurons, Rab5 and Rab21 localize to different populations of early endosomes and preferentially regulate clathrin- and caveolin-mediated endocytic pathways, respectively. This suggests that there is heterogeneity in early endosomes and the pathways run in parallel with different molecular regulation and physiological functions.
Article
Neurosciences
Soulmee Koh, Wongyoung Lee, Sang Myun Park, Sung Hyun Kim
Summary: The study demonstrates the important role of Cav1 in synaptic vesicle exocytosis, with its knockdown significantly impairing synaptic vesicle function. Neurons rescued by triple mutants lacking palmitoylation sites of Cav1 show impairments in both synaptic transmission and retrieval, highlighting the importance of Cav1 palmitoylation in activity-driven synaptic vesicle dynamics.
Article
Multidisciplinary Sciences
Patricia M. R. Pereira, Komal Mandleywala, Sebastien Monette, Melissa Lumish, Kathryn M. Tully, Sandeep Surendra Panikar, Mike Cornejo, Audrey Mauguen, Ashwin Ragupathi, Nai C. Keltee, Marissa Mattar, Yelena Y. Janjigian, Jason S. Lewis
Summary: This study demonstrates that high levels of caveolin-1 (CAV1) reduce the survival benefit of Trastuzumab in HER2-positive gastric cancer patients. Modulating CAV1 levels, particularly with cholesterol-depleting drugs such as statins, can improve the efficacy of antibody drugs.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Wei Jiang, Jiarong Wang, Weiju Xue, Jiao Xin, Congjian Shi, Jiagen Wen, Xiaowen Feng, Yan Huang, Chengmu Hu
Summary: The study demonstrated that CAV-1 can reduce the aggravation of lipid deposition by APAP in AFL mice and activate autophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Giovanni Smaldone, Elisabetta Rosa, Enrico Gallo, Carlo Diaferia, Giancarlo Morelli, Mariano Stornaiuolo, Antonella Accardo
Summary: Hydrogel nanoparticles, also called nanogels, can be used as supramolecular vehicles for delivering biologically relevant molecules. Understanding the intracellular mechanism of nanogel uptake by cancer cells can contribute to their potential diagnostic and clinical applications.
Review
Biochemistry & Molecular Biology
Nicolas Means, Chandra Kumar Elechalawar, Wei R. Chen, Resham Bhattacharya, Priyabrata Mukherjee
Summary: This review focuses on the less studied endocytosis mechanism of macropinocytosis and discusses the endocytosis of nanoparticles, including macropinocytosis. It explores how the physio-chemical properties of nanoparticles affect their intracellular uptake and their potential as tools for identifying new adapter molecules regulating these processes.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nahee Hwang, Bo Kyung Yoon, Kyu-Hye Chun, Hyeonhui Kim, Yoseob Lee, Jae-Won Kim, Hyeonuk Jeon, Tae-Hyun Kim, Mi-Young Kim, Sungsoon Fang, Jae-Ho Cheong, Jae-woo Kim
Summary: A new study reveals that Caveolin-1 (CAV1) is specifically expressed in the most malignant SEM-type gastric cancer (GC), and CAV1-driven endocytosis is a critical survival mechanism of malignant GC. Researchers found that chloroquine (CQ), an anti-malarial drug known to block endocytosis, effectively induced cell death in CAV1-positive SEM-type GC cells by impairing lysosomal activity and extracellular nutrient uptake. In patient-derived organoids and mouse models, CQ treatment significantly reduced tumor growth and improved survival rates, suggesting its potential as a therapeutic alternative for chemo-resistant SEM-type GC patients. The study highlights the importance of targeting endocytosis in cancer treatment and provides new insights into the development of personalized therapies for GC patients.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Saerom Lee, Ga-Eun Lim, Yong-Nyun Kim, Hyeon-Sook Koo, Jaegal Shim
Summary: The study identified the crucial roles of dpy-23 and lon-2 genes in regulating ECM through the TGF-beta signaling pathway, affecting the expression of collagen genes and cuticle components. The upregulation of cav-1 gene in the hypodermis of dpy-23 mutant resulted in decreased T beta RI expression and influenced cuticle formation. These findings contribute to a better understanding of the complex process of ECM regulation in development and disease conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Federico Valli, Maria C. Garcia Vior, Sergio D. Ezquerra Riega, Leonor P. Roguin, Julieta Marino
Summary: In this study, the role of melanosomes in photodynamic therapy (PDT) for melanoma treatment was explored. The results indicate that synthetic photosensitizer Pc13 is internalized by caveolae-mediated endocytosis in melanoma cells and targets melanosomes. After irradiation, damage to melanosomes and release of cytotoxic intermediates contribute to phototoxic response. Melanin, however, antagonizes the phototoxic action of the photosensitizer.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Neurosciences
Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yang
Summary: This study found that abnormal expression of caveolin-1 (Cav1) in Fragile X syndrome (FXS) patients leads to enhanced mGluR-dependent long-term depression (LTD) and further induces endocytosis of AMPA receptor. Massive cholesterol accumulation contributes to redundant caveolae formation, and alleviating FXS symptoms can be achieved by cholesterol depletion.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Virology
Yuyang Wang, Yangyang Zhang, Wei Zuo, Zongyi Bo, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu
Summary: In this study, it was demonstrated that the sigma B protein of ARV interacts with Cav-1 during lipid raft-mediated endocytosis, highlighting the significance of Cav-1 in ARV entry.
Article
Biochemistry & Molecular Biology
Jiarong Zhang, Min Gao, Zhuoya Gao, Yingchao Hou, Jing Liang, Jinjin Lu, Shuai Gao, Boqi Li, Yufeng Gao, Jinghua Chen
Summary: In this study, we proposed a novel approach to improve gene transfection efficiency by altering the endocytosis pathway of nanocarriers. Our findings showed that calcium phosphate nanoparticles coated with glycosaminoglycan could be internalized by cells mainly through caveolin-mediated endocytosis pathway, bypassing the lysosome route and enhancing transfection efficiency. These nanoparticles exhibited efficient cellular uptake, protection of genes from degradation, and reduced cytotoxicity. This research provides a valuable method to enhance gene transfection efficiency and is important for the design of next-generation in vitro transfection reagents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Virology
Qiongyi Li, Yang Liu, Shujuan Xu, Kexue Zhao, Ying Ling, Rongxiu Liu, Amjad Ali, Jialin Bai
Summary: This study uncovered that caveolin-1, dynamin, and actin-dependent endocytosis pathways are necessary for EMCV infection in vitro. Overexpression of caveolin-1 was positively correlated with EMCV infection, and caveolin-1 was found to be required at the early stage of EMCV infection through confocal microscopy analysis and internalization assay.
Article
Biochemistry & Molecular Biology
Myungsik Yoo, Doo Chul Choi, Aleta Murphy, Atiq M. Ahsan, Eunsung Junn
Summary: Neurodegenerative diseases involve the decline and death of neurons, and understanding the molecular mechanisms behind neuronal death is important for therapeutic development. MiRs are small RNAs that regulate gene expression, and their dysregulation has been linked to neurodegenerative diseases. In this study, the researchers investigated miR-593-5p and its role in neuronal death caused by mitochondrial dysfunction. They found that miR-593-5p was increased in response to exposure to MPP+ and contributed to cell death by inhibiting a pathway involving PINK1 and Parkin. These findings suggest that miR-593-5p may be a potential therapeutic target for neurodegenerative diseases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
Donghee Kim, Hyo-Jin Kim, Seon-Heui Cha, Hee-Sook Jun
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Immunology
Eun-Yi Ko, Soo-Jin Heo, Su-Hyeon Cho, WonWoo Lee, Seo-Young Kim, Hye-Won Yang, Ginnae Ahn, Seon-Heui Cha, Seung-Hae Kwon, Myeong Seon Jeong, Kang Pa Lee, You-Jin Jeon, Kil-Nam Kim
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Su-Hyeon Cho, Soo-Jin Heo, Hye-Won Yang, Eun-Yi Ko, Myeong Seon Jung, Seon-Heui Cha, Ginnae Ahn, You-Jin Jeon, Kil-Nam Kim
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2019)
Article
Chemistry, Medicinal
Seon-Heui Cha, Yongha Hwang, Soo-Jin Heo, Hee-Sook Jun
Article
Biochemistry & Molecular Biology
Lei Wang, Hyun Soo Kim, Jun-Geon Je, Jae Young Oh, Young-Sang Kim, Seon-Heui Cha, You-Jin Jeon
Article
Pharmacology & Pharmacy
Eui Jeong Han, Ilekuttige Priyan Shanura Fernando, Eun-A Kim, Junseong Kim, Kyungsook Jung, Seo-Young Kim, Seon-Heui Cha, Kil-Nam Kim, Soo-Jin Heo, Ginnae Ahn
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Food Science & Technology
Lei Wang, WonWoo Lee, Thilina U. Jayawardena, Seon-Heui Cha, You-Jin Jeon
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Chemistry, Medicinal
Seon-Heui Cha, Yongha Hwang, Soo-Jin Heo, Hee-Sook Jun
Article
Biochemistry & Molecular Biology
Seon-Heui Cha, Chunying Zhang, Soo-Jin Heo, Hee-Sook Jun
Summary: BPCA is considered as a potential compound for protecting pancreatic beta-cells by reducing cellular damage, preventing ROS overproduction, and enhancing GSIS. Additionally, it improves mitochondrial morphology and exhibits a protective effect against beta-cell dysfunction in a zebrafish model. These results suggest that BPCA could be a potential therapeutic agent for managing diabetes.
Article
Neurosciences
Tae-Young Ha, Yu Ree Choi, Hye Rin Noh, Seon-Heui Cha, Jae-Bong Kim, Sang Myun Park
Summary: The study demonstrates that with age, Cav-1 expression in the brain increases and significantly increases in the brain of A53T alpha-syn transgenic mice. Overexpression of Cav-1 facilitates the uptake of alpha-syn into neurons and formation of additional Lewy body-like inclusion bodies. Phosphorylation of Cav-1 at tyrosine 14 plays a crucial role in this process.
Article
Chemistry, Medicinal
Nalae Kang, Seong-Yeong Heo, Seon-Heui Cha, Ginnae Ahn, Soo-Jin Heo
Summary: This study assessed aldehyde derivatives from seaweeds as potential inhibitors of SARS-CoV-2 using computer simulation. The compounds were analyzed for their ADME/Tox properties and docked with the 3C-like protease. Among these compounds, 3,4-dihydroxybenzaldehyde showed potential as a SARS-CoV-2 inhibitor.
Article
Chemistry, Medicinal
Eun-A Kim, Nalae Kang, Seong-Young Heo, Jae-Young Oh, Seung-Hong Lee, Seon-Heui Cha, Won-Keun Kim, Soo-Jin Heo
Summary: The study reveals that Tetraselmis species, a type of green microalgae, has broad-spectrum health-promoting activities including antioxidant, antiviral, and anti-inflammatory effects. The extract enriched with lutein shows great potential for industrial applications in pharmaceutical and food industries.
Article
Polymer Science
Lei Wang, Jae-Young Oh, Hye-Won Yang, Jimin Hyun, Ginnae Ahn, Xiaoting Fu, Jiachao Xu, Xin Gao, Seon-Heui Cha, You-Jin Jeon
Summary: This study evaluated the protective effect of fucoidan from Sargassum fusiforme against ethanol-induced oxidative damage. Results showed that fucoidan effectively decreased the damage to liver cells and increased the survival rate of zebrafish. These findings suggest the potential of fucoidan as an ingredient in the functional food industry.
Article
Medicine, Research & Experimental
Phyu Phyu Khin, Seon-Heui Cha, Hee-Sook Jun, Jong Han Lee
MEDICAL HYPOTHESES
(2020)
Article
Medicine, General & Internal
Yongha Hwang, Seon-Heui Cha, Yeonhee Hong, Ae Ryang Jung, Hee-Sook Jun
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2019)