Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroimaging in pre-motor Parkinson's disease

(2017) Thomas R. Barber et al.   NeuroImage-Clinical

Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts

(2017) Usman Saeed et al.   Translational Neurodegeneration

Association between Parkinson's Disease andHelicobacter Pylori

(2016) Gülşah Çamcı et al.   Journal of Clinical Neurology

Gut microbiota and central nervous system development

(2016) Nicola Principi et al.   JOURNAL OF INFECTION

Building on 50 years of levodopa therapy

(2016) The Lancet Neurology   LANCET NEUROLOGY

Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

(2016) Maria G Dominguez-Bello et al.   NATURE MEDICINE

The Infant Microbiome

(2016) Irene Yang et al.   NURSING RESEARCH

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Gut dysfunction in Parkinson's disease

(2016) Adreesh Mukherjee et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

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Increased Risk of Depression in Patients with Parkinson Disease: A Nationwide Cohort Study

(2015) Yi-Ting Hsu et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Food for the Brain

(2015) Charles S. Zuker   CELL

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease

(2015) Peter T. McKenney et al.   CELL

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Control of Brain Development, Function, and Behavior by the Microbiome

(2015) Timothy R. Sampson et al.   Cell Host & Microbe

Simultaneous gas-chromatographic urinary measurement of sugar probes to assess intestinal permeability: Use of time course analysis to optimize its use to assess regional gut permeability

(2015) Maliha Shaikh et al.   CLINICA CHIMICA ACTA

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Small intestine dysfunction in Parkinson’s disease

(2015) Justyna Dutkiewicz et al.   JOURNAL OF NEURAL TRANSMISSION

Constipation preceding Parkinson's disease: a systematic review and meta-analysis

(2015) Kerala L Adams-Carr et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurodegenerative noncommunicable diseases (Neurology NCDs). Where are we now?

(2015) Raad Shakir   JOURNAL OF THE NEUROLOGICAL SCIENCES

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Brain and other nervous system disorders across the lifespan — global challenges and opportunities

(2015) Donald Silberberg et al.   NATURE

Fetal programming of schizophrenia: Select mechanisms

(2015) Monojit Debnath et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Isovaleric acid in stool correlates with human depression

(2015) Olga Szczesniak et al.   NUTRITIONAL NEUROSCIENCE

Reduced plasma serotonin and 5-hydroxyindoleacetic acid levels in Parkinson's disease are associated with nonmotor symptoms

(2015) Qing Tong et al.   PARKINSONISM & RELATED DISORDERS

Increased urinary indoxyl sulfate (indican): New insights into gut dysbiosis in Parkinson's disease

(2015) Erica Cassani et al.   PARKINSONISM & RELATED DISORDERS

The “psychomicrobiotic”: Targeting microbiota in major psychiatric disorders: A systematic review

(2015) G. Fond et al.   PATHOLOGIE BIOLOGIE

Mother's littlest helpers

(2015) K. Hinde et al.   SCIENCE

Rethinking heritability of the microbiome

(2015) Edward J. van Opstal et al.   SCIENCE

Asthma: Undoing millions of years of coevolution in early life?

(2015) Maria Gloria Dominguez-Bello et al.   Science Translational Medicine

The Gut Microbiota and Nonalcoholic Fatty Liver Disease

(2015) Howard Monsour et al.   SEMINARS IN LIVER DISEASE

Brain-gut-microbiota axis in Parkinson's disease

(2015) Agata Mulak   WORLD JOURNAL OF GASTROENTEROLOGY

Humans differ in their personal microbial cloud

(2015) James F. Meadow et al.   PeerJ

Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

(2015) Honglei Chen et al.   Translational Neurodegeneration

Structural alterations of the intestinal epithelial barrier in Parkinson’s disease

(2015) Thomas Clairembault et al.   Acta Neuropathologica Communications

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

A ‘bird’s eye’ view on the current status and potential benefits of blood biomarkers for Parkinson’s disease

(2014) Michelle M Mielke et al.   Biomarkers in Medicine

Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?

(2014) D. Salat-Foix et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Premotor and nonmotor features of Parkinsonʼs disease

(2014) Jennifer G. Goldman et al.   CURRENT OPINION IN NEUROLOGY

Voxelwise meta-analysis of gray matter anomalies in progressive supranuclear palsy and Parkinson's disease using anatomic likelihood estimation

(2014) Na Shao et al.   Frontiers in Human Neuroscience

The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?

(2014) Giada De Palma et al.   JOURNAL OF PHYSIOLOGY-LONDON

Non-motor symptoms of Parkinson's disease A review…from the past

(2014) Pedro J. Garcia-Ruiz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease

(2014) Daniela Berg et al.   MOVEMENT DISORDERS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Evaluation of Progression Markers in the Premotor Phase of Parkinson's Disease: The Progression Markers in the Premotor Phase Study

(2014) Inga Liepelt-Scarfone et al.   NEUROEPIDEMIOLOGY

Small intestinal bacterial overgrowth in Parkinson's disease

(2014) Ai Huey Tan et al.   PARKINSONISM & RELATED DISORDERS

Mild Parkinsonian Signs in the Elderly – Is There an Association with PD? Crossectional Findings in 992 Individuals

(2014) Stefanie Lerche et al.   PLoS One

Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology

(2014) Kasandra Burgos et al.   PLoS One

Environmental Exposures and the Risk for Alzheimer Disease

(2014) Steven T. DeKosky et al.   JAMA Neurology

Emerging Candidate Biomarkers for Parkinson’s Disease: a Review

(2014) Enrico Saracch   Aging and Disease

Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

(2014) Jose U. Scher et al.   Arthritis & Rheumatology

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Recent developments in biomarkers in Parkinson disease

(2013) Anthony H.V. Schapira   CURRENT OPINION IN NEUROLOGY

Small Intestinal Bacterial Overgrowth and Orocecal Transit Time in Patients of Inflammatory Bowel Disease

(2013) S. V. Rana et al.   DIGESTIVE DISEASES AND SCIENCES

Different diagnostic criteria for Parkinson disease: what are the pitfalls?

(2013) Roongroj Bhidayasiri et al.   JOURNAL OF NEURAL TRANSMISSION

PREDICT-PD: Identifying risk of Parkinson's disease in the community: methods and baseline results

(2013) A. J. Noyce et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Parkinson's disease redefined

(2013) Ariel Y Deutch   LANCET NEUROLOGY

Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities

(2013) Daniela Berg et al.   LANCET NEUROLOGY

The role of small intestinal bacterial overgrowth in Parkinson's disease

(2013) Alfonso Fasano et al.   MOVEMENT DISORDERS

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease

(2013) Andrea Gold et al.   MOVEMENT DISORDERS

Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies

(2013) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease

(2013) Leo P. Kelly et al.   MOVEMENT DISORDERS

Biomarkers in Parkinson’s disease (recent update)

(2013) Sushil Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

 -Synuclein in cutaneous autonomic nerves

(2013) N. Wang et al.   NEUROLOGY

Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

(2013) S. Davari et al.   NEUROSCIENCE

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Biomarkers intersect with the exposome

(2012) Stephen M. Rappaport   BIOMARKERS

Recommendations to standardize preanalytical confounding factors in Alzheimer’s and Parkinson’s disease cerebrospinal fluid biomarkers: an update

(2012) Marta del Campo et al.   Biomarkers in Medicine

Combined assessment of midbrain hyperechogenicity, hyposmia and motor asymmetry improves diagnostic accuracy in early Parkinson’s disease

(2012) Werner Poewe et al.   Expert Review of Neurotherapeutics

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

Quantitative Metabolomic Profiling of Serum, Plasma, and Urine by 1H NMR Spectroscopy Discriminates between Patients with Inflammatory Bowel Disease and Healthy Individuals

(2012) Rudolf Schicho et al.   JOURNAL OF PROTEOME RESEARCH

Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-l-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in Horses

(2012) Steven R. Brenner   MEDICAL HYPOTHESES

Parkinson's disease: Evidence for environmental risk factors

(2012) Karl Kieburtz et al.   MOVEMENT DISORDERS

Defining at-risk populations for Parkinson's disease: Lessons from ongoing studies

(2012) Daniela Berg et al.   MOVEMENT DISORDERS

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

(2012) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Techniques used to characterize the gut microbiota: a guide for the clinician

(2012) Marianne H. Fraher et al.   Nature Reviews Gastroenterology & Hepatology

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Gut microbiota and gastrointestinal health: current concepts and future directions

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Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study

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A Prospective Study of Bowel Movement Frequency and Risk of Parkinson's Disease

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Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

(2011) Maurizio Gabrielli et al.   MOVEMENT DISORDERS

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

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(2011) Maria G. Cersosimo et al.   NEUROBIOLOGY OF DISEASE

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Brain?Gut?Microbe Communication in Health and Disease

(2011) Sue Grenham et al.   Frontiers in Physiology

Cortisol is higher in parkinsonism and associated with gait deficit

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(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats

(2010) Rodolphe Soret et al.   GASTROENTEROLOGY

When does Parkinson's disease begin?

(2010) Carles Gaig et al.   MOVEMENT DISORDERS

Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: A pathogenetically based approach

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Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

(2010) Thibaud Lebouvier et al.   PLoS One

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Interview - Searching for biomarkers in Parkinson's disease

(2009) Clemens Scherzer   Biomarkers in Medicine

Mood and gut feelings

(2009) Paul Forsythe et al.   BRAIN BEHAVIOR AND IMMUNITY

The tight junction in inflammatory disease: communication breakdown

(2009) Karen L Edelblum et al.   CURRENT OPINION IN PHARMACOLOGY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Medical records documentation of constipation preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

Abnormal colonic motility in mice overexpressing human wild-type α-synuclein

(2009) Lixin Wang et al.   NEUROREPORT

A profile of volatile organic compounds in breath discriminates COPD patients from controls

(2009) J.J.B.N. Van Berkel et al.   RESPIRATORY MEDICINE

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

(2008) M. Bogdanov et al.   BRAIN

Peripheral cytokines profile in Parkinson’s disease

(2008) M. Reale et al.   BRAIN BEHAVIOR AND IMMUNITY

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(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Pathological lesions in colonic biopsies during Parkinson's disease

(2008) T Lebouvier et al.   GUT

Tight junctions and the modulation of barrier function in disease

(2008) Carola Förster   HISTOCHEMISTRY AND CELL BIOLOGY

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(2008) Daniela Berg et al.   LANCET NEUROLOGY

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(2007) Sean S. O'Sullivan et al.   MOVEMENT DISORDERS