Rediscovery of NF-κB signaling in nasopharyngeal carcinoma: How genetic defects of NF-κB pathway interplay with EBV in driving oncogenesis?

The regulation of tumor cell physiology by mitochondrial dynamics

(2018) David F. Kashatus   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced aerobic glycolysis of nasopharyngeal carcinoma cells by Epstein-Barr virus latent membrane protein 1

(2017) Wei-Wen Sung et al.   EXPERIMENTAL CELL RESEARCH

Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance

(2017) Xiao-Feng Li et al.   HEPATOLOGY

Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6

(2017) Noritaka Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Inflammation Response Index (SIRI), cancer stem cells and survival of localised gastric adenocarcinoma after curative resection

(2017) Sen Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

NOR1 Suppresses Cancer Stem-Like Cells Properties of Tumor Cells via the Inhibition of the AKT-GSK-3β-Wnt/β-catenin-ALDH1A1 Signal Circuit

(2017) Wei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1–Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study

(2017) Chiun Hsu et al.   JOURNAL OF CLINICAL ONCOLOGY

Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

(2017) Xun Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

(2017) Cong-Fa Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

(2017) Stefan B. Eichmüller et al.   JNCI-Journal of the National Cancer Institute

Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-κB Signaling Pathways

(2017) Jun Zhang et al.   JOURNAL OF VIROLOGY

Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-Based Subtypes

(2017) Li Zhang et al.   MOLECULAR CANCER RESEARCH

Nasopharyngeal carcinoma super-enhancer–driven ETV6 correlates with prognosis

(2017) Liangru Ke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening

(2017) Anne G. Christensen et al.   STEM CELLS

Celastrol-induced apoptosis in human nasopharyngeal carcinoma is associated with the activation of the death receptor and the mitochondrial pathway

(2017) Heng-Fu Lin et al.   Oncology Letters

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

(2017) Yvonne Y Li et al.   Nature Communications

Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related-protein 1

(2017) Teng-Jian Zhou et al.   Theranostics

Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs

(2017) Ohad Yogev et al.   PLoS Pathogens

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

(2017) Stefan B. Eichmüller et al.   JNCI-Journal of the National Cancer Institute

Tumor cells PD-L1 expression as a favorable prognosis factor in nasopharyngeal carcinoma patients with pre-existing intratumor-infiltrating lymphocytes

(2017) Qian Zhu et al.   OncoImmunology

Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism

(2016) Yanyan Cai et al.   CANCER CELL

Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells

(2016) Wei-Wen Sung et al.   CANCER LETTERS

Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells

(2016) Shilpi Saha et al.   CANCER RESEARCH

Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice

(2016) Parameswaran Ramakrishnan et al.   DIABETES

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells

(2016) Nicole Messina et al.   JOURNAL OF AUTOIMMUNITY

PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

(2016) Xi-wen Bi et al.   Journal of Hematology & Oncology

Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment

(2016) Gyong Hwa Hong et al.   JOURNAL OF IMMUNOLOGY

NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma

(2016) Rob J. A. Verhoeven et al.   JOURNAL OF VIROLOGY

Nasopharyngeal carcinoma

(2016) Melvin L K Chua et al.   LANCET

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma

(2016) Shumin Wang et al.   MEDIATORS OF INFLAMMATION

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

(2016) Karpagam Veerappan et al.   PHARMACEUTICAL BIOLOGY

NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression

(2016) Rosa Mistica C. Ignacio et al.   PLoS One

Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma

(2016) Hong Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

(2016) Amanda L. Rinkenbaugh et al.   Oncotarget

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages

(2016) Rob J. W. Arts et al.   OncoImmunology

CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells

(2015) Susan J. Burke et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The role of CCL20/CCR6 axis in recruiting Treg cells to tumor sites of NSCLC patients

(2015) Chun-yang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

CTL- vs Treg lymphocyte-attracting chemokines, CCL4 and CCL20, are strong reciprocal predictive markers for survival of patients with oesophageal squamous cell carcinoma

(2015) J Y Liu et al.   BRITISH JOURNAL OF CANCER

Integrated Genomic Analysis Suggests MLL3 Is a Novel Candidate Susceptibility Gene for Familial Nasopharyngeal Carcinoma

(2015) M. M. Sasaki et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth

(2015) Hufeng Zhou et al.   Cell Host & Microbe

The relationship between CCR6 and its binding partners: Does the CCR6–CCL20 axis have to be extended?

(2015) Adrian Y.S. Lee et al.   CYTOKINE

A Functional Insertion/Deletion Polymorphism in the Promoter Region of theNFKB1Gene Increases the Risk of Papillary Thyroid Carcinoma

(2015) Xunli Wang et al.   Genetic Testing and Molecular Biomarkers

Regulation of CD4+FOXP3+ T cells by CCL20/CCR6 axis in early unexplained recurrent miscarriage patients

(2015) X.X. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Significance of NF-κB activation in immortalization of nasopharyngeal epithelial cells

(2015) Dan Dan Zhu et al.   INTERNATIONAL JOURNAL OF CANCER

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

(2015) JUN HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Treg(s) in Cancer: Friends or Foe?

(2015) Dominik Wolf et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells

(2015) Angela Kwok-Fung Lo et al.   JOURNAL OF PATHOLOGY

Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8

(2015) Y Jiang et al.   ONCOGENE

CCL20-CCR6 Cytokine Network Facilitate TregActivity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma

(2015) W.-M. Li et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Contribution of metabolic reprogramming to macrophage plasticity and function

(2015) Karim C. EL Kasmi et al.   SEMINARS IN IMMUNOLOGY

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration

(2015) Yekaterina Y. Zaytseva et al.   Oncotarget

Parthenolide Inhibits Cancer Stem-Like Side Population of Nasopharyngeal Carcinoma Cells via Suppression of the NF-κB/COX-2 Pathway

(2015) Kun Liao et al.   Theranostics

Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells

(2015) Chiara Rancan et al.   PLoS Pathogens

Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma

(2015) Minzhong Tang et al.   Biomed Research International

Lactic acid polarizes macrophages to a tumor-promoting state

(2015) Oscar R Colegio   OncoImmunology

Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB

(2015) Kavitha Gowrishankar et al.   PLoS One

EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy

(2015) Wenfeng Fang et al.   Oncotarget

Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor

(2014) H Nishio et al.   BRITISH JOURNAL OF CANCER

The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma

(2014) Marta Celegato et al.   CANCER LETTERS

CCL20/CCR6-mediated migration of regulatory T cells to theHelicobacter pylori-infected human gastric mucosa

(2014) Katherine W Cook et al.   GUT

Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

(2014) Dhafer Mrizak et al.   JNCI-Journal of the National Cancer Institute

Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF- B Pathways: Impairment in T Cell Functions

(2014) W.-l. Liu et al.   JOURNAL OF VIROLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

The genomic landscape of nasopharyngeal carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

(2014) L Xiao et al.   ONCOGENE

Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-κB in Prostate Carcinoma Cells

(2014) Kun-Chun Chiang et al.   PLoS One

Cancer stem-like cell: a novel target for nasopharyngeal carcinoma therapy

(2014) Pingpin Wei et al.   Stem Cell Research & Therapy

Molecular Basis of NF-κB Signaling

(2013) Johanna Napetschnig et al.   Annual Review of Biophysics

The functional −94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer

(2013) Mohd Shafi’i Mohd Suzairi et al.   Cancer Epidemiology

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Tumor necrosis factor alpha induces Warburg-like metabolism and is reversed by anti-inflammatory curcumin in breast epithelial cells

(2013) Roger A. Vaughan et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells

(2013) Angela Kwok-Fung Lo et al.   JOURNAL OF PATHOLOGY

Constitutive activation of distinct NF-κB signals in EBV-associated nasopharyngeal carcinoma

(2013) Grace Tin-Yun Chung et al.   JOURNAL OF PATHOLOGY

Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells

(2013) Guitao Zhang et al.   PLoS One

Efficient Immortalization of Primary Nasopharyngeal Epithelial Cells for EBV Infection Study

(2013) Yim Ling Yip et al.   PLoS One

Tumor necrosis factor alpha increases aerobic glycolysis and reduces oxidative metabolism in prostate epithelial cells

(2013) Roger A. Vaughan et al.   PROSTATE

CCR6/CCL20 Chemokine Expression Profile in Distinct Colorectal Malignancies

(2013) V. O. Frick et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Therapeutic targeting of regulatory T cells enhances tumor-specific CD8+ T cell responses in Epstein–Barr virus associated nasopharyngeal carcinoma

(2013) Mark Fogg et al.   VIROLOGY

c-Myc and EBV–LMP1: two opposing regulators of the HLA class I antigen presentation machinery in epithelial cells

(2012) C S Tudor et al.   BRITISH JOURNAL OF CANCER

EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: Implications for viral immune escape

(2012) Martina Severa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Tumor Suppressor CYLD Controls the Function of Murine Regulatory T Cells

(2012) S. Reissig et al.   JOURNAL OF IMMUNOLOGY

Deregulation of lipid metabolism pathway genes in nasopharyngeal carcinoma cells

(2012) MAELINDA DAKER et al.   Molecular Medicine Reports

Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells

(2012) C. M. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Therapeutic Approach to Nasopharyngeal Carcinomas by DNAzymes Targeting EBV LMP-1 Gene

(2011) Lifang Yang et al.   MOLECULES

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes

(2011) R Zaynagetdinov et al.   ONCOGENE

Endogenous latent membrane protein 1 in Epstein–Barr virus-infected nasopharyngeal carcinoma cells attracts T lymphocytes through upregulation of multiple chemokines

(2010) Hsiao-Ching Lai et al.   VIROLOGY

A functional insertion/deletion polymorphism in the promoter region of the NFKB1 gene increases susceptibility for prostate cancer

(2009) Peng Zhang et al.   CANCER GENETICS AND CYTOGENETICS

A small molecule inhibitor of NF-κB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells

(2009) Jason Ho Ting Wong et al.   CANCER LETTERS

Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced ζ-chain expression in nasopharyngeal carcinoma patients

(2009) W. K. Yip et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of the Epstein–Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma

(2009) Mhairi A Morris et al.   Future Oncology

A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma

(2008) Bin Zhou et al.   CANCER LETTERS

Macrophage Inflammatory Protein-3  Is a Novel Serum Marker for Nasopharyngeal Carcinoma Detection and Prediction of Treatment Outcomes

(2008) K.-P. Chang et al.   CLINICAL CANCER RESEARCH

Epstein-Barr Virus-Induced miR-155 Attenuates NF- B Signaling and Stabilizes Latent Virus Persistence

(2008) F. Lu et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Latent Membrane Protein 1 Induces Expression of the Epidermal Growth Factor Receptor through Effects on Bcl-3 and STAT3

(2008) C.-P. Kung et al.   JOURNAL OF VIROLOGY

Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway

(2008) Graziana Gatto et al.   NUCLEIC ACIDS RESEARCH