Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

SynTarget: an online tool to test the synergetic effect of genes on survival outcome in cancer

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Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

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Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

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Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis

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YAP and TAZ Take Center Stage in Cancer

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17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells

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Effect of PPARδ Agonist on Stearoyl-CoA Desaturase 1 in Human Pancreatic Cancer Cells: Role of MEK/ERK1/2 Pathway

(2015) Shima Byagowi et al.   Canadian Journal of Diabetes

SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway

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Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids

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An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression

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YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

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Roles of the Hippo pathway in lung development and tumorigenesis

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Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target

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Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification

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Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer

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YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

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An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer

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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

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Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation

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Metabolic control of YAP and TAZ by the mevalonate pathway

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TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

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The Biology of YAP/TAZ: Hippo Signaling and Beyond

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Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging

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Molecular Pathways: YAP and TAZ Take Center Stage in Organ Growth and Tumorigenesis

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Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

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Wnt interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells

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Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells

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Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins

(2013) Jessica Rios-Esteves et al.   Cell Reports

Decreasing stearoyl-CoA desaturase-1 expression inhibits β-catenin signaling in breast cancer cells

(2012) Daniel Mauvoisin et al.   CANCER SCIENCE

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer

(2012) Mian Xie et al.   Journal of Thoracic Oncology

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

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Cancer Cell Metabolism: One Hallmark, Many Faces

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The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates

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The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

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BioProfiling.de: analytical web portal for high-throughput cell biology

(2011) A. V. Antonov   NUCLEIC ACIDS RESEARCH

TAZ is a novel oncogene in non-small cell lung cancer

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Spheres Derived from Lung Adenocarcinoma Pleural Effusions: Molecular Characterization and Tumor Engraftment

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Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer

(2010) Yang Wang et al.   CANCER SCIENCE

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Inhibition of Stearoyl-CoA Desaturase 1 Expression Induces CHOP-Dependent Cell Death in Human Cancer Cells

(2010) Mélaine Minville-Walz et al.   PLoS One

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

(2009) Serge Léger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS