Energy transfer in "parasitic" cancer metabolism

Mitochondrial Biogenesis Drives Tumor Cell Proliferation

(2011) Ubaldo E. Martinez-Outschoorn et al.   AMERICAN JOURNAL OF PATHOLOGY

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Inflammation and autophagy conspire to promote tumor growth

(2011) Hasan Korkaya et al.   CELL CYCLE

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Understanding the metabolic basis of drug resistance

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth

(2011) Renee M. Balliet et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A return to cancer metabolism

(2011) Gregg L. Semenza   JOURNAL OF MOLECULAR MEDICINE-JMM

Oxidative Stress in Children with Severe Malaria

(2011) N. Narsaria et al.   JOURNAL OF TROPICAL PEDIATRICS

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

(2011) S. K. Das et al.   SCIENCE

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment

(2010) Nagi B. Kumar et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Trypanosoma cruziInduces the Reactive Oxygen Species-PARP-1-RelA Pathway for Up-regulation of Cytokine Expression in Cardiomyocytes

(2010) Xueqing Ba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Host Interactions: A Far-Reaching Relationship

(2010) Sandra S. McAllister et al.   JOURNAL OF CLINICAL ONCOLOGY

Phenyl-α-tert-butyl-nitrone and Benzonidazole Treatment Controlled the Mitochondrial Oxidative Stress and Evolution of Cardiomyopathy in Chronic Chagasic Rats

(2010) Jian-Jun Wen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clues from cell metabolism

(2010) William G. Kaelin et al.   NATURE

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

The autophagic pathway is a key component in the lysosomal dependent entry ofTrypanosoma cruziinto the host cell

(2009) Patricia S. Romano et al.   Autophagy

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

(2009) Kathryn N. Phoenix et al.   BREAST CANCER RESEARCH AND TREATMENT

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase

(2008) M. Zakikhani et al.   Cancer Prevention Research

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Selective Association of Plasma Non-esterified Fatty Acid Species with Circulating Interleukin-8 Concentrations in Humans

(2008) H. Staiger et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis

(2008) Sumanta Dey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles

(2008) Takeshi Hashimoto et al.   PLoS One

Breast cancer by proxy: can the microenvironment be both the cause and consequence?

(2008) Lone Rønnov-Jessen et al.   TRENDS IN MOLECULAR MEDICINE