CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation
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Title
CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 32, Pages E6556-E6565
Publisher
Proceedings of the National Academy of Sciences
Online
2017-08-09
DOI
10.1073/pnas.1703791114
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Note: Only part of the references are listed.- Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer
- (2016) Brittney S Harrington et al. BRITISH JOURNAL OF CANCER
- Targeting CDCP1 dimerization in triple-negative breast cancer
- (2016) Heather J. Wright et al. CELL CYCLE
- Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption
- (2016) Jue Hou et al. JOURNAL OF BIOMEDICAL OPTICS
- Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
- (2016) Roman Camarda et al. NATURE MEDICINE
- Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells
- (2016) Hua Lin et al. NEURO-ONCOLOGY
- Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma
- (2016) J M Thompson et al. ONCOGENE
- CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer
- (2016) H J Wright et al. ONCOGENE
- Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
- (2016) Mahesh S. Padanad et al. Cell Reports
- Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
- (2016) Jun Hyoung Park et al. Cell Reports
- Enhanced OXPHOS, glutaminolysis and -oxidation constitute the metastatic phenotype of melanoma cells
- (2015) M. F. Rodrigues et al. BIOCHEMICAL JOURNAL
- Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
- (2015) Angelika S. Rambold et al. DEVELOPMENTAL CELL
- Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance
- (2015) Y He et al. ONCOGENE
- Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism
- (2015) Jessica M. Ellis et al. PLoS One
- Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma
- (2015) Fabienne Guillaumond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update
- (2015) Sheng Yan WORLD JOURNAL OF GASTROENTEROLOGY
- ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis
- (2015) Kuo-Liang Chiu et al. Scientific Reports
- Interaction of CDCP1 with HER2 Enhances HER2-Driven Tumorigenesis and Promotes Trastuzumab Resistance in Breast Cancer
- (2015) Abdullah Alajati et al. Cell Reports
- Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect
- (2015) Chung-Ling Lu et al. PLoS One
- Acyl-CoA Metabolism and Partitioning
- (2014) Trisha J. Grevengoed et al. Annual Review of Nutrition
- CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells
- (2014) David J Orchard-Webb et al. BMC CANCER
- Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
- (2014) Shuhua Yue et al. Cell Metabolism
- Hallmarks of triple negative breast cancer emerging at last?
- (2014) Rosa Bernardi et al. CELL RESEARCH
- CUB-domain containing protein 1 represses the epithelial phenotype of pancreatic cancer cells
- (2014) Shin Miura et al. EXPERIMENTAL CELL RESEARCH
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
- (2014) Hyun Mi Kang et al. NATURE MEDICINE
- Multiparametric Spectroscopic Photoacoustic Imaging of Breast Cancer Development in a Transgenic Mouse Model
- (2014) Katheryne E. Wilson et al. Theranostics
- A Mitochondrial Switch Promotes Tumor Metastasis
- (2014) Paolo E. Porporato et al. Cell Reports
- Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
- (2013) F. Baenke et al. Disease Models & Mechanisms
- Isolation and Phenotypic Characterization of Colorectal Cancer Stem Cells With Organ-Specific Metastatic Potential
- (2013) Wenchao Gao et al. GASTROENTEROLOGY
- Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
- (2013) M. Cecilia Caino et al. JOURNAL OF CLINICAL INVESTIGATION
- The Apoptosis Repressor with a CARD Domain (ARC) Gene Is a Direct Hypoxia-Inducible Factor 1 Target Gene and Promotes Survival and Proliferation of VHL-Deficient Renal Cancer Cells
- (2013) O. V. Razorenova et al. MOLECULAR AND CELLULAR BIOLOGY
- CDCP1 Regulates the Function of MT1-MMP and Invadopodia-Mediated Invasion of Cancer Cells
- (2013) Yuri Miyazawa et al. MOLECULAR CANCER RESEARCH
- Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy
- (2013) Gwendlyn Kollmorgen et al. Molecular Oncology
- Effect of Desiccating Stress on Mouse Meibomian Gland Function
- (2013) Jeffrey L. Suhalim et al. Ocular Surface
- Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients
- (2013) Brooke M. Emerling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
- (2013) H. Zirath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles
- (2013) Jules A. Nchoutmboube et al. PLoS Pathogens
- Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
- (2012) D. S. Spassov et al. CANCER RESEARCH
- The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake
- (2012) Margarete Poppelreuther et al. JOURNAL OF LIPID RESEARCH
- Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms
- (2012) M E Law et al. ONCOGENE
- In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling
- (2012) B Casar et al. ONCOGENE
- Infrared spectral signatures of CDCP1-induced effects in colon carcinoma cells
- (2011) Ibraheem Yousef et al. ANALYST
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- (2011) T. D. Russell et al. JOURNAL OF CELL SCIENCE
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- (2011) B Casar et al. ONCOGENE
- VHLloss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKCδ-driven migration
- (2011) Olga V. Razorenova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains
- (2010) Eric Soupene et al. BMC BIOCHEMISTRY
- CUB Domain–Containing Protein 1, a Prognostic Factor for Human Pancreatic Cancers, Promotes Cell Migration and Extracellular Matrix Degradation
- (2010) Yuri Miyazawa et al. CANCER RESEARCH
- Two-Photon Microscopy for Non-Invasive, Quantitative Monitoring of Stem Cell Differentiation
- (2010) William L. Rice et al. PLoS One
- Suppression of Long Chain Acyl-CoA Synthetase 3 Decreases Hepaticde NovoFatty Acid Synthesis through Decreased Transcriptional Activity
- (2009) So Young Bu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid droplet-organelle interactions; sharing the fats
- (2008) Samantha Murphy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
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