Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma

Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice

(2017) Na Li et al.   HEPATOLOGY

p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A

(2015) Z Zhu et al.   ONCOGENE

SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism

(2015) Yan Sun et al.   TUMOR BIOLOGY

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

(2015) Shruti Desai et al.   Oncotarget

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells

(2014) Yuhui Jiang et al.   Nature Communications

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

(2013) K. J. Williams et al.   CANCER RESEARCH

Mediating lipid biosynthesis: Implications for cardiovascular disease

(2013) Xiaoli et al.   TRENDS IN CARDIOVASCULAR MEDICINE

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis

(2012) Weihua Li et al.   CELL CYCLE

Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1

(2012) Xiaoping Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma

(2008) Taro Yamashita et al.   JOURNAL OF HEPATOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE