EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling

Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer

(2017) Nadia B. Hassounah et al.   MOLECULAR CANCER RESEARCH

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

(2017) S E Conduit et al.   ONCOGENE

INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma

(2017) N Yang et al.   ONCOGENE

Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells

(2017) Chen Zhao et al.   SCIENCE

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

(2017) Deepika Neelakantan et al.   Nature Communications

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Primary cilia are increased in number and demonstrate structural abnormalities in human cancer

(2016) Binnaz Yasar et al.   JOURNAL OF CLINICAL PATHOLOGY

Tissue-specific designs of stem cell hierarchies

(2016) Jane E. Visvader et al.   NATURE CELL BIOLOGY

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling

(2015) Elisa Maria Memmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway

(2015) Mingli Zhou et al.   STEM CELLS

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

(2015) Bingchen Han et al.   Cell Reports

Mammary stem cells and the differentiation hierarchy: current status and perspectives

(2014) J. E. Visvader et al.   GENES & DEVELOPMENT

In situ identification of bipotent stem cells in the mammary gland

(2014) Anne C. Rios et al.   NATURE

Cell-State Transitions Regulated by SLUG Are Critical for Tissue Regeneration and Tumor Initiation

(2014) Sarah Phillips et al.   Stem Cell Reports

Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes

(2013) Aleix Prat et al.   BREAST CANCER RESEARCH AND TREATMENT

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

Absence of primary cilia in cell cycle-arrested human breast cancer cells

(2013) Kentaro Nobutani et al.   GENES TO CELLS

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland

(2012) Elena García-Zaragoza et al.   DEVELOPMENTAL BIOLOGY

Slug Controls Stem/Progenitor Cell Growth Dynamics during Mammary Gland Morphogenesis

(2012) Mayssa Nassour et al.   PLoS One

Semi-quantitative evaluation of CD44+/CD24− tumor cell distribution in breast cancer tissue using a newly developed fluorescence immunohistochemical staining method

(2011) Masaya Kai et al.   CANCER SCIENCE

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

(2011) Theresa A. Proia et al.   Cell Stem Cell

Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened

(2011) Adriana P. Visbal et al.   DEVELOPMENTAL BIOLOGY

Distinct stem cells contribute to mammary gland development and maintenance

(2011) Alexandra Van Keymeulen et al.   NATURE

Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development

(2010) Kimberly M. McDermott et al.   CURRENT BIOLOGY

Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues

(2010) Kun Yuan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Primary Cilium-Dependent and -Independent Hedgehog Signaling Inhibits p16INK4A

(2010) Cleo L. Bishop et al.   MOLECULAR CELL

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Development of Mammary Tumors by Conditional Expression of GLI1

(2009) M. Fiaschi et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Reciprocal Intraepithelial Interactions Between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells

(2008) Na Li et al.   STEM CELLS