Extracellular HMGB1 as a therapeutic target in inflammatory diseases

Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains

(2018) Yusuke Hayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy

(2018) Teresa Ravizza et al.   BRAIN BEHAVIOR AND IMMUNITY

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment

(2017) Juciano Gasparotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

(2017) Lauren Elizabeth Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation

(2017) H. Yang et al.   JOURNAL OF INTERNAL MEDICINE

The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer’s-Related Pathology via HMGB1 Inhibition

(2017) Zhong-Hong Kong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

(2017) Yuhei Irie et al.   Journal of Neuroimmune Pharmacology

Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis

(2017) Ilias Masouris et al.   Journal of Neuroinflammation

Affibody Molecules in Biotechnological and Medical Applications

(2017) Stefan Ståhl et al.   TRENDS IN BIOTECHNOLOGY

HMGB proteins and arthritis

(2017) Noboru Taniguchi et al.   Human Cell

TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells and protects mice from lethal influenza infection

(2017) Laure Perrin-Cocon et al.   Scientific Reports

Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice

(2017) Li Fu et al.   Scientific Reports

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

(2017) Natalie E. Stevens et al.   Scientific Reports

Characterization of the Inflammatory Properties of Actively Released HMGB1 in Juvenile Idiopathic Arthritis

(2016) Peter Lundbäck et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Dependent HMGB1 Isoforms as Pivotal Co-Ordinators of Drug-Induced Liver Injury: Mechanistic Biomarkers and Therapeutic Targets

(2016) Jonathan D. Lea et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses

(2016) Yiting Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

C1q and HMGB1 reciprocally regulate human macrophage polarization

(2016) M. Son et al.   BLOOD

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

(2016) K. Stark et al.   BLOOD

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

The Alarmin Properties of DNA and DNA-associated Nuclear Proteins

(2016) Melinda Magna et al.   CLINICAL THERAPEUTICS

Long-Term Quality of Life Among Survivors of Severe Sepsis

(2016) Sachin Yende et al.   CRITICAL CARE MEDICINE

Recent advances in biomarkers and therapeutic interventions for hepatic drug safety – false dawn or new horizon?

(2016) Joanna I. Clarke et al.   Expert Opinion On Drug Safety

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock

(2016) Murielle Grégoire et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

(2016) Laura K. Fonken et al.   JOURNAL OF NEUROSCIENCE

Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

(2016) Fleur Schaper et al.   MOLECULAR MEDICINE

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats

(2016) Takeshi Nishida et al.   TOXICOLOGY

Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS

(2016) Jie Yang et al.   Cell Death & Disease

Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats

(2016) Niccolò Terrando et al.   Frontiers in Immunology

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

(2015) Chhinder P. Sodhi et al.   JOURNAL OF IMMUNOLOGY

The American Geriatrics Society/National Institute on Aging Bedside-to-Bench Conference: Research Agenda on Delirium in Older Adults

(2015)   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

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(2015) Sergio Valdés-Ferrer et al.   MOLECULAR MEDICINE

Unknown

(2015) Huan Yang et al.   MOLECULAR MEDICINE

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products

(2015) Yan Chen et al.   PLoS One

The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE

(2014) David S. Pisetsky   AUTOIMMUNITY

Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain

(2014) Yohance M. Allette et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptor 4 is associated with seizures following ischemia with hyperglycemia

(2014) Yanling Liang et al.   BRAIN RESEARCH

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

Anemia of Inflammation

(2014) Elizabeta Nemeth et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

An Immunogenic Peptide in the A-box of HMGB1 Protein Reverses Apoptosis-induced Tolerance through RAGE Receptor

(2014) Philippe M. LeBlanc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

The functions of HMGB1 depend on molecular localization and post-translational modifications

(2014) U. Andersson et al.   JOURNAL OF INTERNAL MEDICINE

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Unknown

(2014) Fleur Schaper et al.   MOLECULAR MEDICINE

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

(2014) Nilesh M. Agalave et al.   PAIN

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Mobility Group Box 1 Inhibition Alleviates Lupus-Like Disease in BXSB Mice

(2014) C. Zhang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis

(2013) Christopher Höhne et al.   BRAIN

Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats

(2013) Junichi Tanaka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

(2013) Cherilyn M. Sirois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6Chighinflammatory monocytes in murine sepsis survivors

(2013) S. I. Valdés-Ferrer et al.   JOURNAL OF INTERNAL MEDICINE

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis

(2013) Junichi Tanaka et al.   NEUROPHARMACOLOGY

Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus

(2013) Zhen Li et al.   NEUROREPORT

Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1

(2013) Yoki Nakamura et al.   PLoS One

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

High-mobility group box 1 contributes to mechanical allodynia and spinal astrocytic activation in a mouse model of type 2 diabetes

(2012) Peng-Cheng Ren et al.   BRAIN RESEARCH BULLETIN

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

(2012) M. E. Benoit et al.   JOURNAL OF IMMUNOLOGY

The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain

(2012) Polina Feldman et al.   Journal of Neuroinflammation

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Activation of Toll-Like Receptor 4 Is Necessary for Trauma Hemorrhagic Shock-Induced Gut Injury and Polymorphonuclear Neutrophil Priming

(2012) Diego C. Reino et al.   SHOCK

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications

(2011) Ravichandran Ramasamy et al.   Annals of the New York Academy of Sciences

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

(2011) Ju Ho Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock

(2011) Stéphanie Barnay-Verdier et al.   INTENSIVE CARE MEDICINE

Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1

(2011) M. Maroso et al.   JOURNAL OF INTERNAL MEDICINE

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

(2011) Jieun Choi et al.   Journal of Neuroinflammation

Serum Levels of HMGB1 in Postmenopausal Patients with Rheumatoid Arthritis: Associations with Proinflammatory Cytokines, Acute-phase Reactants, and Clinical Disease Characteristics

(2011) R. PULLERITS et al.   JOURNAL OF RHEUMATOLOGY

Perioperative Cognitive Decline in the Aging Population

(2011) Niccolò Terrando et al.   MAYO CLINIC PROCEEDINGS

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(2011) Hanna Schierbeck et al.   MOLECULAR MEDICINE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Anti-HMGB1 Neutralization Antibody Improves Pain-Related Behavior Induced by Application of Autologous Nucleus Pulposus Onto Nerve Roots in Rats

(2011) Ken-ichi Otoshi et al.   SPINE

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus

(2011) Deena A Abdulahad et al.   ARTHRITIS RESEARCH & THERAPY

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

(2010) Therese Östberg et al.   ARTHRITIS AND RHEUMATISM

Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain

(2010) Wei Tong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-alpha and TNF-alpha in systemic lupus erythematosus

(2010) Chun-yan Ma et al.   RHEUMATOLOGY INTERNATIONAL

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Factors associated with serum high mobility group box 1 (HMGB1) levels in a general population

(2009) Ako Fukami et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

(2008) Takashi Ito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

(2008) Takashi Hamada et al.   ARTHRITIS AND RHEUMATISM

Internalization of the Receptor for Advanced Glycation End Products (RAGE) is Required to Mediate Intracellular Responses

(2008) Natalia Sevillano et al.   JOURNAL OF BIOCHEMISTRY

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications

(2007) Giuseppina Basta   ATHEROSCLEROSIS