HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

S100A12 and the S100/CalgranulinsSignificance

(2015) Adam Oesterle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The S100 proteins in epidermis: Topology and function

(2015) Wiesława Leśniak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of S100 proteins and their receptor RAGE in pancreatic cancer

(2015) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins

(2015) Mohd W. Nasser et al.   CANCER LETTERS

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Immunity, inflammation, and cancer: an eternal fight between good and evil

(2015) Shabnam Shalapour et al.   JOURNAL OF CLINICAL INVESTIGATION

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

(2015) Chhinder P. Sodhi et al.   JOURNAL OF IMMUNOLOGY

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

(2015) Michael Bode et al.   THROMBOSIS AND HAEMOSTASIS

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1α, for the Treatment of Psoriasis

(2015) Kyle M. Coleman et al.   JAMA Dermatology

Effective Combination Therapy of Polymyxin-B Direct Hemoperfusion and Recombinant Thrombomodulin for Septic Shock Accompanied by Disseminated Intravascular Coagulation: A Historical Controlled Trial

(2015) Masafumi Yamato et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Interleukin 1α Sustains the Expression of Inflammatory Factors in Human Pancreatic Cancer Microenvironment by Targeting Cancer-Associated Fibroblasts

(2015) Vegard Tjomsland et al.   NEOPLASIA

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4

(2014) D. Rohde et al.   EMBO Molecular Medicine

S100a8/a9 Released by CD11b + Gr1 + Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II–Induced Cardiac Inflammation and Injury

(2014) Yina Wu et al.   HYPERTENSION

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes

(2014) A. A. Manfredi et al.   JOURNAL OF IMMUNOLOGY

IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

(2014) N. E. Humphreys et al.   JOURNAL OF IMMUNOLOGY

Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15

(2014) R. Wolf et al.   JOURNAL OF IMMUNOLOGY

IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

(2014) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

(2014) Selina K. Fassl et al.   JOURNAL OF IMMUNOLOGY

MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study

(2014) David S Hong et al.   LANCET ONCOLOGY

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traumatic Brain Injury: Lungs in a RAGE

(2014) M. R. Nicolls et al.   Science Translational Medicine

The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation

(2014) D. J. Weber et al.   Science Translational Medicine

Unique versus redundant functions of IL-1α and IL-1β in the tumor microenvironment

(2014) Elena Voronov   Frontiers in Immunology

HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway

(2013) Ying Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

Interleukins and Atherosclerosis: A Dysfunctional Family Grows

(2013) Larry D. Spears et al.   Cell Metabolism

Joining S100 proteins and migration: for better or for worse, in sickness and in health

(2013) Stephane R. Gross et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cellular signalling of the receptor for advanced glycation end products (RAGE)

(2013) Jianling Xie et al.   CELLULAR SIGNALLING

HMGB1 in Cancer: Good, Bad, or Both?

(2013) R. Kang et al.   CLINICAL CANCER RESEARCH

Immunohistochemical detection of S100A1 in the postmortem diagnosis of acute myocardial infarction

(2013) Haitao Bi et al.   Diagnostic Pathology

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

(2013) Marina Bersudsky et al.   GUT

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

IL-1 signaling in atherosclerosis: sibling rivalry

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

(2013) R Kang et al.   ONCOGENE

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

(2013) H. Yanai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

(2012) S. Jube et al.   CANCER RESEARCH

Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

(2012) Shane Deegan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functions of S100 Proteins

(2012) R. Donato et al.   CURRENT MOLECULAR MEDICINE

High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

(2012) Wei Yan et al.   HEPATOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis

(2012) Christophe Cataisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

(2012) J R van Beijnum et al.   ONCOGENE

N-Terminal Domain of Nuclear IL-1α Shows Structural Similarity to the C-Terminal Domain of Snf1 and Binds to the HAT/Core Module of the SAGA Complex

(2012) Blanka Zamostna et al.   PLoS One

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

(2012) E. F. Castillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

(2012) Peleg Rider et al.   Frontiers in Immunology

Vascular Remodeling and Arterial Calcification Are Directly Mediated by S100A12 (EN-RAGE) in Chronic Kidney Disease

(2011) Joseph Gawdzik et al.   AMERICAN JOURNAL OF NEPHROLOGY

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α

(2011) Yehuda Kamari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

The IL1α-S100A13 Heterotetrameric Complex Structure

(2011) Sepuru K. Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Urokinase Plasminogen Activator (uPA)-mediated Atherosclerosis

(2011) Stephen D. Farris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner

(2011) F. Riuzzi et al.   JOURNAL OF CELL SCIENCE

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus

(2011) V. Urbonaviciute et al.   JOURNAL OF INTERNAL MEDICINE

S100B-RAGE dependent VEGF secretion by cardiac myocytes induces myofibroblast proliferation

(2011) James N. Tsoporis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma

(2011) Y. Qin et al.   MOLECULAR CANCER RESEARCH

S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

(2011) M. Ichikawa et al.   MOLECULAR CANCER RESEARCH

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

(2011) Jie Lu et al.   PLoS One

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 

(2011) Y. Berda-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of multiple serum markers in advanced melanoma

(2011) Angel Díaz-Lagares et al.   TUMOR BIOLOGY

High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus

(2011) Deena A Abdulahad et al.   ARTHRITIS RESEARCH & THERAPY

The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation

(2011) Guglielmo Sorci et al.   PLoS Pathogens

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative Modifications of DAMPs Suppress Inflammation: The Case for S100A8 and S100A9

(2010) Su Yin Lim et al.   ANTIOXIDANTS & REDOX SIGNALING

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

S100A12 in Vascular Smooth Muscle Accelerates Vascular Calcification in Apolipoprotein E–Null Mice by Activating an Osteogenic Gene Regulatory Program

(2010) Marion A. Hofmann Bowman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The redox protein HMGB1 regulates cell death and survival in cancer treatment

(2010) Daolin Tang et al.   Autophagy

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Platelet interleukin-1  drives cerebrovascular inflammation

(2010) P. Thornton et al.   BLOOD

Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice

(2010) Ashley M. Miller et al.   CIRCULATION RESEARCH

Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells

(2010) D.G.A. Burton et al.   EXPERIMENTAL GERONTOLOGY

Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity

(2010) Günter Fritz et al.   FEBS Journal

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Carboxylated N-glycans on RAGE promote S100A12 binding and signaling

(2010) Geetha Srikrishna et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Epithelial Cells Promote Fibroblast Activation via IL-1α in Systemic Sclerosis

(2010) Nima Aden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains

(2010) Katherine Stott et al.   JOURNAL OF MOLECULAR BIOLOGY

Expression of High Mobility Group Box Chromosomal Protein 1 and Its Modulating Effects on Downstream Cytokines in Systemic Lupus Erythematosus

(2010) J. LI et al.   JOURNAL OF RHEUMATOLOGY

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

(2010) L Liu et al.   LEUKEMIA

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: A systematic review

(2010) Anant MOHAN et al.   RESPIROLOGY

Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases

(2010) A. Baillet et al.   RHEUMATOLOGY

Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-alpha and TNF-alpha in systemic lupus erythematosus

(2010) Chun-yan Ma et al.   RHEUMATOLOGY INTERNATIONAL

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Interleukin-1α stimulates proinflammatory cytokine expression in human cardiac myofibroblasts

(2009) Neil A. Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2–IL-33 Pathway

(2009) Jennifer Kearley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biomarkers in melanoma

(2009) H. Gogas et al.   ANNALS OF ONCOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis

(2009) Gaby Palmer et al.   ARTHRITIS AND RHEUMATISM

Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma

(2009) Xiaojin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function

(2009) Olga V Moroz et al.   BMC BIOCHEMISTRY

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Criteria for a Clinically Informative Serum Biomarker in Acute Ischaemic Stroke: A Review of S100B

(2009) Pooja Dassan et al.   CEREBROVASCULAR DISEASES

S100B Interaction With the Receptor for Advanced Glycation End Products (RAGE)

(2009) J.N. Tsoporis et al.   CIRCULATION RESEARCH

Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia

(2009) Masaru Nagato et al.   CRITICAL CARE MEDICINE

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

S100 Calgranulins in inflammatory arthritis

(2009) Chandima Perera et al.   IMMUNOLOGY AND CELL BIOLOGY

Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo

(2009) Susan Hoppmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage

(2009) Dominique Talabot-Ayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pleiotropic Roles of S100A12 in Coronary Atherosclerotic Plaque Formation and Rupture

(2009) J. Goyette et al.   JOURNAL OF IMMUNOLOGY

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells

(2009) D. Prefontaine et al.   JOURNAL OF IMMUNOLOGY

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

(2009) T. Ohno et al.   JOURNAL OF IMMUNOLOGY

The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis

(2009) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism

(2009) Y. J. Oh et al.   JOURNAL OF IMMUNOLOGY

Oxidative modifications of S100 proteins: functional regulation by redox

(2009) Su Yin Lim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased Levels of Interleukin 33 in Sera and Synovial Fluid from Patients with Active Rheumatoid Arthritis

(2009) Y. MATSUYAMA et al.   JOURNAL OF RHEUMATOLOGY

Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer

(2009) Hye Chung et al.   Journal of Translational Medicine

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Autoinflammatory Disease Due to Homozygous Deletion of theIL1RNLocus

(2009) Sreelatha Reddy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Calprotectin — A Novel Marker of Obesity

(2009) Ole Hartvig Mortensen et al.   PLoS One

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

(2008) Takashi Hamada et al.   ARTHRITIS AND RHEUMATISM

Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis

(2008) P. L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

(2008) Olga Turovskaya et al.   CARCINOGENESIS

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

S100-annexin complexes - biology of conditional association

(2008) Naofumi Miwa et al.   FEBS Journal

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation

(2008) Yan Zheng et al.   IMMUNOLOGY

The prognostic value of serum S100B in patients with cutaneous melanoma: A meta-analysis

(2008) Simone Mocellin et al.   INTERNATIONAL JOURNAL OF CANCER

Mast Cell and Monocyte Recruitment by S100A12 and Its Hinge Domain

(2008) Wei Xing Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

(2008) Evis Harja et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 reduces the development of atherosclerosis

(2008) Ashley M. Miller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evidence of platelet activation in multiple sclerosis

(2008) William A Sheremata et al.   Journal of Neuroinflammation

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Unknown

(2008) John Klune et al.   MOLECULAR MEDICINE

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

IL-33 exacerbates antigen-induced arthritis by activating mast cells

(2008) D. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

(2008) Therese Ostberg et al.   ARTHRITIS RESEARCH & THERAPY

S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes

(2007) Takamasa Nukui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY