High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing

(2011) Jean-Marc Tadié et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Peptidoglycan Induces Necrosis and Regulates Cytokine Production in Murine Trophoblast Stem Cells

(2011) Jennifer A. Rose et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

High Mobility Group Box 1 in Cerebrospinal Fluid From Several Neurological Diseases at Early Time Points

(2011) Takeshi Asano et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis

(2011) Bianca Woehrl et al.   JOURNAL OF CLINICAL INVESTIGATION

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

The Effect of HMGB1, a Damage-Associated Molecular Pattern Molecule, on Polymorphonuclear Neutrophil Migration Depends on Its Concentration

(2011) Florence Berthelot et al.   Journal of Innate Immunity

Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

(2011) Xingfen Su et al.   MEDIATORS OF INFLAMMATION

Bacterial Meningitis in the United States, 1998–2007

(2011) Michael C. Thigpen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Attenuation of Cerebrospinal Fluid Inflammation by the Nonbacteriolytic Antibiotic Daptomycin versus That by Ceftriaxone in Experimental Pneumococcal Meningitis

(2010) D. Grandgirard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo

(2010) D. Frommhold et al.   BLOOD

Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo

(2010) N. Loukili et al.   CARDIOVASCULAR RESEARCH

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

(2010) M. C. Brouwer et al.   CLINICAL MICROBIOLOGY REVIEWS

Mechanisms of injury in bacterial meningitis

(2010) Joachim Gerber et al.   CURRENT OPINION IN NEUROLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Inhibitor of NF- B Kinases   and   Are Both Essential for High Mobility Group Box 1-Mediated Chemotaxis

(2010) M. Penzo et al.   JOURNAL OF IMMUNOLOGY

CXCL16 Contributes to Neutrophil Recruitment to Cerebrospinal Fluid in Pneumococcal Meningitis

(2010) Bianca Woehrl et al.   JOURNAL OF INFECTIOUS DISEASES

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Brain Injury as a Target of Adjunctive Therapy in Bacterial Meningitis

(2010) Uwe Koedel et al.   Current Infectious Disease Reports

A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis*

(2009) Daolin Tang et al.   CRITICAL CARE MEDICINE

The Receptor for Advanced Glycation End Products Impairs Host Defense in Pneumococcal Pneumonia

(2009) M. A. D. van Zoelen et al.   JOURNAL OF IMMUNOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

(2009) Marieke A.D. van Zoelen et al.   SHOCK

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury

(2008) Yingkai Feng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

(2008) Matthias Klein et al.   JOURNAL OF INFECTIOUS DISEASES

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Acidic stress induces autolysis by a CSP-independent ComE pathway in Streptococcus pneumoniae

(2008) G. E. Pinas et al.   MICROBIOLOGY-SGM

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY