Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

(2016) Yanyan Cen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

(2016) Daichi Yamasoba et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The toll-like receptor 4 antagonist transforming growth factor-β-activated kinase(TAK)-242 attenuates taurocholate-induced oxidative stress through regulating mitochondrial function in mice pancreatic acinar cells

(2016) Long-Fei Pan et al.   JOURNAL OF SURGICAL RESEARCH

Resistin aggravates the expression of proinflammatory cytokines in cerulein-stimulated AR42J pancreatic acinar cells

(2016) Chong-Yi Jiang et al.   Molecular Medicine Reports

Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation

(2015) Yongxia Cai et al.   DIGESTIVE DISEASES AND SCIENCES

Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases

(2015) Takashi Ito et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2/NF-κB and SAPK/JNK pathway

(2015) S. Choudhury et al.   FREE RADICAL RESEARCH

Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy

(2015) Fang Fang Zhang et al.   JOURNAL OF NEUROCHEMISTRY

SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation

(2015) Fei Yang et al.   Journal of Neuroinflammation

Efficacy of recombinant human soluble thrombomodulin in preventing walled-off necrosis in severe acute pancreatitis patients

(2015) Takaaki Eguchi et al.   PANCREATOLOGY

High-mobility group box 1 protein and its role in severe acute pancreatitis

(2015) Xiao Shen   WORLD JOURNAL OF GASTROENTEROLOGY

Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain

(2014) Yohance M. Allette et al.   BRAIN BEHAVIOR AND IMMUNITY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis

(2014) Yuka Terada et al.   JOURNAL OF NEUROSCIENCE RESEARCH

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(2014) Rui Kang et al.   MOLECULAR MEDICINE

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

(2014) Nilesh M. Agalave et al.   PAIN

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress and inflammatory signaling in cerulein pancreatitis

(2014) Ji Hoon Yu   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury

(2014) Maria Entezari et al.   Redox Biology

Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats

(2013) Junichi Tanaka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis

(2013) Kazuma Yamakawa et al.   INTENSIVE CARE MEDICINE

Contribution of TRPA1 as a Downstream Signal of Proteinase-Activated Receptor-2 to Pancreatic Pain

(2013) Yuka Terada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis

(2013) Junichi Tanaka et al.   NEUROPHARMACOLOGY

Opuntia humifusa Ameliorated Cerulein-Induced Acute Pancreatitis

(2013) Sun Bok Choi et al.   PANCREAS

The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates inflammation and fibrosis in a mouse model of chronic pancreatitis

(2012) Han Bai et al.   BMC GASTROENTEROLOGY

CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice

(2012) Keita Saeki et al.   GASTROENTEROLOGY

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain

(2012) Polina Feldman et al.   Journal of Neuroinflammation

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

The high mobility group box: the ultimate utility player of a cell

(2012) Christopher S. Malarkey et al.   TRENDS IN BIOCHEMICAL SCIENCES

High-mobility group box family of proteins: ligand and sensor for innate immunity

(2012) Hideyuki Yanai et al.   TRENDS IN IMMUNOLOGY

Spinal Microglia Initiate and Maintain Hyperalgesia in a Rat Model of Chronic Pancreatitis

(2011) Pei–Yi Liu et al.   GASTROENTEROLOGY

Calcium/calmodulin-dependent protein kinase (CaMK) Iα mediates the macrophage inflammatory response to sepsis

(2011) Xianghong Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Thrombomodulin and its role in inflammation

(2011) Edward M. Conway   Seminars in Immunopathology

Anti-HMGB1 Neutralization Antibody Improves Pain-Related Behavior Induced by Application of Autologous Nucleus Pulposus Onto Nerve Roots in Rats

(2011) Ken-ichi Otoshi et al.   SPINE

Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: Evidence for involvement of distinct mechanisms

(2010) Osamu Fukushima et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury

(2010) Masayuki Shibasaki et al.   PAIN

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The translocation of HMGB1 during cell activation and cell death

(2009) Julie Gauley et al.   AUTOIMMUNITY

Hydrogen sulfide as a novel mediator for pancreatic pain in rodents

(2009) S Nishimura et al.   GUT

DANAPAROID SODIUM PREVENTS CERULEIN-INDUCED ACUTE PANCREATITIS IN RATS

(2009) Satoshi Hagiwara et al.   SHOCK

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The RAGE Pathway

(2008) Ivan K. Lukic et al.   Annals of the New York Academy of Sciences

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

(2008) Takashi Ito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pancreatic pain

(2008) Güralp O. Ceyhan et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Pancreatic Neuropathy and Neuropathic Pain—A Comprehensive Pathomorphological Study of 546 Cases

(2008) Güralp O. Ceyhan et al.   GASTROENTEROLOGY

Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice

(2006) Atsufumi Kawabata et al.   BRITISH JOURNAL OF PHARMACOLOGY