Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

(2018) Jian-Zhi Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Quality of Life Among Survivors of Severe Sepsis

(2016) Sachin Yende et al.   CRITICAL CARE MEDICINE

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

(2016) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic effects of antigen affinity-purified polyclonal anti-receptor of advanced glycation end-product (RAGE) antibodies on cholestasis-induced liver injury in rats

(2016) Peng Xia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer’s Disease

(2016) Florence Guillot et al.   JOURNAL OF ALZHEIMERS DISEASE

Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways

(2016) Shi Shi et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus

(2016) Yan Hong et al.   NEUROCHEMICAL RESEARCH

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

Sleep fragmentation and sepsis differentially impact blood–brain barrier integrity and transport of tumor necrosis factor-α in aging

(2015) Mark R. Opp et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles

(2015) Gerhard Multhaup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-βProduction in Alzheimer’s Disease

(2015) Li Zuo et al.   Oxidative Medicine and Cellular Longevity

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

(2015) Colm Cunningham et al.   Alzheimers Research & Therapy

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

Crosstalk between ERK, AKT, and cell survival

(2014) Paul Dent   CANCER BIOLOGY & THERAPY

Microglial Aβ Receptors in Alzheimer’s Disease

(2014) Yang Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

(2014) Julio Tobon-Velasco et al.   CNS & Neurological Disorders-Drug Targets

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer’s Disease Therapeutic Application

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Investigation of phosphoproteome in RAGE signaling

(2014) Kedar B. Batkulwar et al.   PROTEOMICS

RAGE blockade and hepatic microcirculation in experimental endotoxaemic liver failure

(2013) A. Kuhla et al.   BRITISH JOURNAL OF SURGERY

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Unknown

(2013) Felipe Dal-Pizzol et al.   MOLECULAR MEDICINE

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

The Inside-Out Amyloid Hypothesis and Synapse Pathology in Alzheimer's Disease

(2013) Gunnar K. Gouras et al.   Neurodegenerative Diseases

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils

(2011) Estibaliz Capetillo-Zarate et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation

(2011) Xiao-Hong Li et al.   NEUROBIOLOGY OF AGING

PF-04494700, an Oral Inhibitor of Receptor for Advanced Glycation End Products (RAGE), in Alzheimer Disease

(2010) Marwan N. Sabbagh et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Long-term mortality and quality of life in sepsis: A systematic review*

(2010) Bradford D. Winters et al.   CRITICAL CARE MEDICINE

The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?

(2010) Benedict C. Creagh-Brown et al.   INTENSIVE CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

(2010) Victoria E. Johnson et al.   NATURE REVIEWS NEUROSCIENCE

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer’s disease animal model

(2009) H. J. Cho et al.   FASEB JOURNAL

Receptor for Advanced Glycation End Products Facilitates Host Defense duringEscherichia coli–Induced Abdominal Sepsis in Mice

(2009) Marieke A. D. van Zoelen et al.   JOURNAL OF INFECTIOUS DISEASES

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau pathophysiology in neurodegeneration: a tangled issue

(2009) Tara L. Spires-Jones et al.   TRENDS IN NEUROSCIENCES

The RAGE Pathway

(2008) Ivan K. Lukic et al.   Annals of the New York Academy of Sciences

Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism

(2008) Alexander Semmler et al.   Journal of Neuroinflammation

Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid- -Mediated Cortical Synaptic Dysfunction

(2008) N. Origlia et al.   JOURNAL OF NEUROSCIENCE