HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria

(2014) A. Chorny et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

(2010) Therese Östberg et al.   ARTHRITIS AND RHEUMATISM

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats*

(2010) Rongqian Wu et al.   CRITICAL CARE MEDICINE

Expression of High Mobility Group Box Chromosomal Protein 1 and Its Modulating Effects on Downstream Cytokines in Systemic Lupus Erythematosus

(2010) J. LI et al.   JOURNAL OF RHEUMATOLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia

(2009) Runkuan Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Anchoring Fusion Thrombomodulin to the Endothelial Lumen Protects against Injury-induced Lung Thrombosis and Inflammation

(2009) Bi-Sen Ding et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ethyl Pyruvate Attenuates Spinal Cord Ischemic Injury with a Wide Therapeutic Window through Inhibiting High-mobility Group Box 1 Release in Rabbits

(2009) Qiang Wang et al.   ANESTHESIOLOGY

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

(2009) Marjolein A. van Maanen et al.   ARTHRITIS AND RHEUMATISM

Effect of Polymyxin B-Immobilized Fiber Hemoperfusion on Serum High Mobility Group Box-1 Protein Levels and Oxidative Stress in Patients With Acute Respiratory Distress Syndrome

(2009) Tsukasa Nakamura et al.   ASAIO JOURNAL

The translocation of HMGB1 during cell activation and cell death

(2009) Julie Gauley et al.   AUTOIMMUNITY

Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia

(2009) Masaru Nagato et al.   CRITICAL CARE MEDICINE

Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies

(2009) Cecilia Grundtman et al.   FASEB JOURNAL

Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury

(2009) Jon Cardinal et al.   HEPATOLOGY

Ethyl pyruvate administration inhibits hepatic tumor growth

(2009) Xiaoyan Liang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways

(2009) Karine Lolmede et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality

(2009) P. Pan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Protective Effect of HMGB1 A Box on Organ Injury of Acute Pancreatitis in Mice

(2009) Hai Yuan et al.   PANCREAS

Plasma Concentrations of High-Mobility Group Box Protein 1, Soluble Receptor for Advanced Glycation End-Products and Circulating DNA in Patients with Acute Pancreatitis

(2009) Á.K. Kocsis et al.   PANCREATOLOGY

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1

(2008) Alejo Chorny et al.   AMERICAN JOURNAL OF PATHOLOGY

Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes

(2008) Huei-Ping Tzeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

(2008) Steven M. Rowe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of High Mobility Group Box1 in Pulmonary Fibrosis

(2008) Naoki Hamada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

(2008) Takashi Hamada et al.   ARTHRITIS AND RHEUMATISM

High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice

(2008) T. Kitahara et al.   CARDIOVASCULAR RESEARCH

Stopping the Primal RAGE Reaction in Myocardial Infarction

(2008) Ravichandran Ramasamy et al.   CIRCULATION

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

High Mobility Group Box 1 Induces a Negative Inotropic Effect on the Left Ventricle in an Isolated Rat Heart Model of Septic Shock

(2008) Satoshi Hagiwara et al.   CIRCULATION JOURNAL

Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart

(2008) Susumu Oozawa et al.   CIRCULATION JOURNAL

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis

(2008) Satoshi Hagiwara et al.   INTENSIVE CARE MEDICINE

HMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE

(2008) Zheng Zhou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation

(2008) Bolin Cai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis

(2008) Runkuan Yang et al.   JOURNAL OF SURGICAL RESEARCH

High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation

(2008) Minna Ilmakunnas et al.   LIVER TRANSPLANTATION

High-Mobility Group Box Proteins Modulate Tumor Necrosis Factor-α Expression in Osteoclastogenesis via a Novel Deoxyribonucleic Acid Sequence

(2008) Kosj Yamoah et al.   MOLECULAR ENDOCRINOLOGY

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(2008) Annette Bruchfeld et al.   MOLECULAR MEDICINE

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(2008) William Parrish et al.   MOLECULAR MEDICINE

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(2008) John Klune et al.   MOLECULAR MEDICINE

Protective Effect of Antagonist of High-mobility Group Box 1 on Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2008) Q. Gong et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Role of High-Mobility Group Box–1 in Renal Ischemia and Reperfusion Injury and the Effect of Ethyl Pyruvate

(2008) K.-Y. Chung et al.   TRANSPLANTATION PROCEEDINGS

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

(2008) Therese Ostberg et al.   ARTHRITIS RESEARCH & THERAPY

Induction and subcellular localization of high-mobility group box–1 (HMGB1) in the postischemic rat brain

(2007) Jung-Bin Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH