TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells and protects mice from lethal influenza infection

Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses

(2016) Gagan Bajwa et al.   JOURNAL OF IMMUNOLOGY

Novel strategies for targeting innate immune responses to influenza

(2016) K A Shirey et al.   Mucosal Immunology

Postulates for validating TLR4 agonists

(2015) Mateja Manček-Keber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

(2015) Zheng Tan et al.   JOURNAL OF IMMUNOLOGY

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

(2015) Timo Wolf et al.   LANCET

Translating Glycolytic Metabolism to Innate Immunity in Dendritic Cells

(2014) Mario Cortese et al.   Cell Metabolism

The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages

(2014) Zheng Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity of Hexokinase Is Increased by Its Interaction with Hepatitis C Virus Protein NS5A

(2014) C. Ramiere et al.   JOURNAL OF VIROLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

(2014) Beatriz Escudero-Pérez et al.   PLoS Pathogens

Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic

(2013) Roberto Cighetti et al.   CHEMBIOCHEM

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bioenergetic Profiles Diverge During Macrophage Polarization: Implications for the Interpretation of 18F-FDG PET Imaging of Atherosclerosis

(2013) S. Tavakoli et al.   JOURNAL OF NUCLEAR MEDICINE

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Modified lipoproteins provide lipids that modulate dendritic cell immune function

(2012) Laure Perrin-Cocon et al.   BIOCHIMIE

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

Danger-associated molecular patterns (DAMPs) in acute lung injury

(2012) Leslie B Tolle et al.   JOURNAL OF PATHOLOGY

Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During Sepsis

(2012) Reinaldo Salomao et al.   SHOCK

Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

(2012) P. Rallabhandi et al.   mBio

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism

(2011) Livia Vastag et al.   PLoS Pathogens

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas

(2010) Cheolho Cheong et al.   CELL

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

(2010) K A Shirey et al.   Mucosal Immunology

Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

(2010) T. Delgado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD14-independent responses induced by a synthetic lipid A mimetic

(2009) Amandine Legat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

CD14 but not MD2 transmit signals from DAMP

(2009) Kyung-Hee Chun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Roles of Toll-Like Receptors in Atherosclerosis

(2009) Clett Erridge   Journal of Innate Immunity

Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1

(2009) A. Okumura et al.   JOURNAL OF VIROLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

(2009) Hideki Nakano et al.   NATURE IMMUNOLOGY

Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart

(2009) David J. Kaczorowski et al.   TRANSPLANTATION

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

(2008) L. Cao et al.   NEUROSCIENCE

Th1 Disabled Function in Response to TLR4 Stimulation of Monocyte-Derived DC from Patients Chronically-Infected by Hepatitis C Virus

(2008) Laure Perrin-Cocon et al.   PLoS One