The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation

Redox-Dependent HMGB1 Isoforms as Pivotal Co-Ordinators of Drug-Induced Liver Injury: Mechanistic Biomarkers and Therapeutic Targets

(2016) Jonathan D. Lea et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

(2016) Vengadeshprabhu Karuppagounder et al.   PLoS One

HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

(2016) Zhaoliang Su et al.   Scientific Reports

Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration

(2015) David C. Irwin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

(2015) Xiaorong Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

(2015) Chhinder P. Sodhi et al.   JOURNAL OF IMMUNOLOGY

Unknown

(2015) Hyong Choi et al.   MOLECULAR MEDICINE

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

Sepsis: Current Dogma and New Perspectives

(2014) Clifford S. Deutschman et al.   IMMUNITY

The synergistic effect of homocysteine and lipopolysaccharide on the differentiation and conversion of raw264.7 macrophages

(2014) Shanshan Gao et al.   Journal of Inflammation-London

High-mobility group box-1 in sterile inflammation

(2014) A. Tsung et al.   JOURNAL OF INTERNAL MEDICINE

TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant

(2014) Rebecca Saenz et al.   Journal of Translational Medicine

Unknown

(2014) Daniel Antoine et al.   MOLECULAR MEDICINE

Circulating AIM as an Indicator of Liver Damage and Hepatocellular Carcinoma in Humans

(2014) Tomoko Yamazaki et al.   PLoS One

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

CD163 Binding to Haptoglobin-Hemoglobin Complexes Involves a Dual-point Electrostatic Receptor-Ligand Pairing

(2013) Marianne Jensby Nielsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent

(2013) Christian A. Schaer et al.   Oxidative Medicine and Cellular Longevity

Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

(2013) Mário Henrique M. Barros et al.   PLoS One

Plasma Clearance of Hemoglobin and Haptoglobin in Mice and Effect of CD163 Gene Targeting Disruption

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Transcriptional Regulation of an Axonemal Central Apparatus Gene, Sperm-associated Antigen 6, by a SRY-related High Mobility Group Transcription Factor, S-SOX5

(2010) Elizabeth Anne Kiselak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Unknown

(2010) Daniel Antoine et al.   MOLECULAR MEDICINE

The CD163-expressing macrophages recognize and internalize TWEAK

(2009) Juan A. Moreno et al.   ATHEROSCLEROSIS

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging

(2009) M. J. Nielsen et al.   BLOOD