Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease
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Title
Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease
Authors
Keywords
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Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 53, Issue 3, Pages 279-310
Publisher
Informa UK Limited
Online
2018-05-03
DOI
10.1080/10409238.2018.1458070
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Note: Only part of the references are listed.- Retrospective on Cholesterol Homeostasis: The Central Role of Scap
- (2018) Michael S. Brown et al. Annual Review of Biochemistry
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- (2018) Cihan Yurdaydin et al. HEPATOLOGY
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- (2018) Sandra Pelleieux et al. NEUROBIOLOGY OF AGING
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- (2018) David Hottman et al. NEUROSCIENCE
- Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins
- (2018) Federica Iannelli et al. Recent Patents on Anti-Cancer Drug Discovery
- The mevalonate pathway in neurons: It's not just about cholesterol
- (2017) Miguel Moutinho et al. EXPERIMENTAL CELL RESEARCH
- Efficient farnesylation of an extended C-terminal C(x)3Xsequence motif expands the scope of the prenylated proteome
- (2017) Melanie J. Blanden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 in Neurodegenerative Diseases
- (2017) Taylor R. Jay et al. Molecular Neurodegeneration
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- (2017) Rebecca Sims et al. NATURE GENETICS
- Elucidating the Role of TREM2 in Alzheimer’s Disease
- (2017) Jason D. Ulrich et al. NEURON
- Combined HMG-COA reductase and prenylation inhibition in treatment of CCM
- (2017) Sayoko Nishimura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TREM2, Microglia, and Neurodegenerative Diseases
- (2017) Felix L. Yeh et al. TRENDS IN MOLECULAR MEDICINE
- New tricks for human farnesyltransferase inhibitor: cancer and beyond
- (2017) Jingyuan Wang et al. MedChemComm
- Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
- (2017) Jaeok Park et al. Nature Communications
- Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience
- (2017) Perry G. Ridge et al. Genome Medicine
- Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease
- (2017) Julie M. Zissimopoulos et al. JAMA Neurology
- Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer’s Disease
- (2017) Juan M. Zolezzi et al. Frontiers in Immunology
- A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
- (2017) Nicholas T. Seyfried et al. Cell Systems
- Regional Selectivity of rab5 and rab7 Protein Upregulation in Mild Cognitive Impairment and Alzheimer's Disease
- (2017) Stephen D. Ginsberg et al. JOURNAL OF ALZHEIMERS DISEASE
- Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells
- (2016) Charuta C. Palsuledesai et al. ACS Chemical Biology
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- Is There Potential for Repurposing Statins as Novel Antimicrobials?
- (2016) Emma Hennessy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells
- (2016) Idrees Mohammed et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Atorvastatin in improvement of cognitive impairments caused by amyloid β in mice: involvement of inflammatory reaction
- (2016) Liandong Zhao et al. BMC Neurology
- Microglial toll-like receptors and Alzheimer’s disease
- (2016) Fan Su et al. BRAIN BEHAVIOR AND IMMUNITY
- Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria SyndromeClinical Perspective
- (2016) Leslie B. Gordon et al. CIRCULATION
- Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain
- (2016) Benjamin W. Henderson et al. JOURNAL OF NEUROCHEMISTRY
- Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration
- (2016) E. G. Gentry et al. JOURNAL OF NEUROSCIENCE
- The Prenylated Proteome ofPlasmodium falciparumReveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action
- (2016) Jolyn E. Gisselberg et al. MOLECULAR & CELLULAR PROTEOMICS
- Protein prenylation: unique fats make their mark on biology
- (2016) Mei Wang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
- (2016) Marco Colonna et al. NATURE REVIEWS NEUROSCIENCE
- Simvastatin inhibits protein isoprenylation in the brain
- (2016) Stephen M. Ostrowski et al. NEUROSCIENCE
- Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue
- (2016) Kiall F. Suazo et al. Scientific Reports
- Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth
- (2016) Hai Li et al. Cell Reports
- A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes
- (2016) Emily R Hildebrandt et al. eLife
- Alzheimer's disease: An acquired neurodegenerative laminopathy
- (2016) Bess Frost Nucleus
- Alzheimer's disease: An acquired neurodegenerative laminopathy
- (2016) Bess Frost Nucleus
- Repurposing Treatments to Enhance Innate Immunity. Can Statins Improve Neutrophil Functions and Clinical Outcomes in COPD?
- (2016) Georgia Walton et al. Journal of Clinical Medicine
- Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier
- (2016) Jarred M. Griffin et al. PLoS One
- Explorative and targeted neuroproteomics in Alzheimer's disease
- (2015) Ann Brinkmalm et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase
- (2015) Dimitrios Gritzalis et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
- (2015) Joseph L. Goldstein et al. CELL
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- (2015) Andreas L. Marzinzik et al. ChemMedChem
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- (2015) Edward W Tate et al. CURRENT OPINION IN CHEMICAL BIOLOGY
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- (2015) V. Briz et al. JOURNAL OF NEUROSCIENCE
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- (2015) Michael T Heneka et al. LANCET NEUROLOGY
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- (2015) Shangfeng Gao et al. MOLECULAR NEUROBIOLOGY
- Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function
- (2015) Juhi Misra et al. STEM CELLS
- Bisphosphonates for the prevention and treatment of osteoporosis
- (2015) Spyridoula Maraka et al. BMJ-British Medical Journal
- Bisphosphonates for the prevention and treatment of osteoporosis
- (2015) Spyridoula Maraka et al. BMJ-British Medical Journal
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- (2014) Yen-Chih Wang et al. ACS Chemical Biology
- The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes
- (2014) Hoang S. Nhan et al. ACTA NEUROPATHOLOGICA
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- (2014) Jonathan K. Dozier et al. BIOCONJUGATE CHEMISTRY
- Dragging Ras Back in the Ring
- (2014) Andrew G. Stephen et al. CANCER CELL
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- (2014) Leslie B. Gordon et al. CIRCULATION
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- (2014) Joris W. De Schutter et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2014) Sravani Musunuri et al. JOURNAL OF PROTEOME RESEARCH
- A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins
- (2014) Charuta C. Palsuledesai et al. Molecular BioSystems
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- (2014) Cesare R. Sirtori PHARMACOLOGICAL RESEARCH
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- (2014) Vinod Udayar et al. Cell Reports
- Statins and Cognitive Function
- (2013) Karl Richardson et al. ANNALS OF INTERNAL MEDICINE
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- (2013) Shaowu Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease
- (2013) Annalisa Cavallini et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) J. H. Herskowitz et al. JOURNAL OF NEUROSCIENCE
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- (2013) A. Nishimura et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2013) X Chen et al. ONCOGENE
- Regulation of Small GTPases by GEFs, GAPs, and GDIs
- (2013) Jacqueline Cherfils et al. PHYSIOLOGICAL REVIEWS
- Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform
- (2013) G. Charron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) A. Quigley et al. SCIENCE
- Deciphering Alzheimer Disease
- (2013) D. Selkoe et al. Cold Spring Harbor Perspectives in Medicine
- Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
- (2013) T. Wyss-Coray et al. Cold Spring Harbor Perspectives in Medicine
- Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes
- (2012) Kalub Hahne et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2012) Yen-Chih Wang et al. CHEMICAL COMMUNICATIONS
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- (2012) Michael S. Brown et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains
- (2012) Victor P. Andreev et al. JOURNAL OF PROTEOME RESEARCH
- Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease
- (2012) Ling Li et al. MOLECULAR NEUROBIOLOGY
- Statins Reduce Amyloid β-Peptide Production by Modulating Amyloid Precursor Protein Maturation and Phosphorylation Through a Cholesterol-Independent Mechanism in Cultured Neurons
- (2012) Ai Hosaka et al. NEUROCHEMICAL RESEARCH
- Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer’s disease
- (2012) Tomoko Kurata et al. NEUROLOGICAL RESEARCH
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation
- (2012) Stephen R. Spindler et al. PLoS One
- Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome
- (2012) L. B. Gordon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections
- (2012) Joshua D. Ochocki et al. MedChemComm
- Cholesterol Level and Statin Use in Alzheimer Disease
- (2011) Nina E. Shepardson ARCHIVES OF NEUROLOGY
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- (2011) Joel A. Bergman et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Bisphosphonates: The first 40years
- (2011) R. Graham G. Russell BONE
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- (2011) Joshua A. Smith et al. BRAIN RESEARCH BULLETIN
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- (2011) Stephen D. Ginsberg et al. JOURNAL OF CHEMICAL NEUROANATOMY
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- (2011) S. Liu et al. JOURNAL OF IMMUNOLOGY
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- (2011) Jing Yang et al. MOLECULAR CELL
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- (2011) Tadanori Hamano et al. NEUROBIOLOGY OF AGING
- Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
- (2011) R.A. Mans et al. NEUROSCIENCE
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- (2011) Kimberley F. Tolias et al. PROGRESS IN NEUROBIOLOGY
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- (2011) Ian A. Prior et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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- (2011) Joel A. Bergman et al. ACS Medicinal Chemistry Letters
- Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity
- (2011) Nir London et al. PLoS Computational Biology
- Synthesis of the Rheb and K-Ras4B GTPases
- (2010) Yong-Xiang Chen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Statins and neuroprotection
- (2010) W. Gibson Wood et al. Annals of the New York Academy of Sciences
- Biochemical and molecular mechanisms of action of bisphosphonates
- (2010) Michael J. Rogers et al. BONE
- Enlarging the Scope of Cell-Penetrating Prenylated Peptides to Include Farnesylated ‘CAAX’ Box Sequences and Diverse Cell Types
- (2010) Joshua D. Ochocki et al. Chemical Biology & Drug Design
- Evaluation of Alkyne-Modified Isoprenoids as Chemical Reporters of Protein Prenylation
- (2010) Amanda J. DeGraw et al. Chemical Biology & Drug Design
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- (2010) A. J. Roelofs et al. CURRENT PHARMACEUTICAL DESIGN
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- (2010) Jeremy H. Herskowitz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Fredrick O. Onono et al. MOLECULAR & CELLULAR PROTEOMICS
- Modulation of Cholesterol, Farnesylpyrophosphate, and Geranylgeranylpyrophosphate in Neuroblastoma SH-SY5Y-APP695 Cells: Impact on Amyloid Beta-Protein Production
- (2010) Gero P. Hooff et al. MOLECULAR NEUROBIOLOGY
- Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery
- (2010) Wolfgang Jahnke et al. Nature Chemical Biology
- Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins
- (2010) Xiaojing Ye et al. NEURON
- Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders
- (2010) Ruth L. Stornetta et al. NEUROSCIENTIST
- Investigation of the sequence and length dependence for cell-penetrating prenylated peptides
- (2009) James W. Wollack et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates
- (2009) Amanda J. Krzysiak et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2009) Lai N. Chan et al. ELECTROPHORESIS
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- (2009) James L. Hougland et al. JOURNAL OF MOLECULAR BIOLOGY
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- (2009) Minna A. Korolainen et al. JOURNAL OF NEUROCHEMISTRY
- Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy
- (2009) Moran Boimel et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
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- (2009) E. G. Reed-Geaghan et al. JOURNAL OF NEUROSCIENCE
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- (2009) James W. Wollack et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2009) A. Kazi et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2009) Ursula Haditsch et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Analysis of the eukaryotic prenylome by isoprenoid affinity tagging
- (2009) Uyen T T Nguyen et al. Nature Chemical Biology
- Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
- (2009) Gunter P. Eckert et al. NEUROBIOLOGY OF DISEASE
- Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice
- (2009) R.A. Mans et al. NEUROSCIENCE
- Membrane-associated farnesylated UCH-L1 promotes -synuclein neurotoxicity and is a therapeutic target for Parkinson's disease
- (2009) Z. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isoprenoid quantitation in human brain tissue: a validated HPLC–fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP)
- (2008) Gero P. Hooff et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue
- (2008) Huaxiang Tong et al. ANALYTICAL BIOCHEMISTRY
- Mapping the Isoprenoid Binding Pocket of PDEδ by a Semisynthetic, Photoactivatable N-Ras Lipoprotein
- (2008) Michael Alexander et al. CHEMBIOCHEM
- Structures of RabGGTase–substrate/product complexes provide insights into the evolution of protein prenylation
- (2008) Zhong Guo et al. EMBO JOURNAL
- A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells
- (2008) Mei Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
- (2008) Ignacio Varela et al. NATURE MEDICINE
- A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
- (2008) B. C. Capell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis
- (2008) X.-P. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ
- (2007) Yan Zhou et al. FASEB JOURNAL
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