Repurposing Treatments to Enhance Innate Immunity. Can Statins Improve Neutrophil Functions and Clinical Outcomes in COPD?

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

(2016) Deepika Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Statin Effects on Exacerbation Rates, Mortality, and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease: A Review of Prospective Studies

(2016) Meredith L. Howard et al.   PHARMACOTHERAPY

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

(2016) Uffe Ravnskov et al.   BMJ Open

Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37

(2016) Hironori Higashio et al.   Scientific Reports

Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment

(2015) Anika Stadtmann et al.   JOURNAL OF IMMUNOLOGY

Rosuvastatin treatment in stable chronic obstructive pulmonary disease (RODEO): a randomized controlled trial

(2015) A. Neukamm et al.   JOURNAL OF INTERNAL MEDICINE

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

(2015) Jessica L Mega et al.   LANCET

The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research

(2015) Chao Cao et al.   Scientific Reports

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophils Cast NETs in Atherosclerosis

(2014) Yvonne Döring et al.   CIRCULATION RESEARCH

Cardiovascular Disease is Associated with COPD Severity and Reduced Functional Status and Quality of Life

(2014) Jennifer L. Black-Shinn et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Inhaled corticosteroids in COPD: the clinical evidence

(2014) Pierre Ernst et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophils in atherosclerosis

(2014) H. Hartwig et al.   Hamostaseologie

Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD

(2014) Gerard J. Criner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statins for Sepsis: Distinguishing Signal from the Noise When Designing Clinical Trials

(2013) Jaimin M. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

Is Exposure to Biomass Smoke the Biggest Risk Factor for COPD Globally?

(2013) Sundeep Salvi et al.   CHEST

Determinants of endothelial function in patients with COPD

(2013) Christian F. Clarenbach et al.   EUROPEAN RESPIRATORY JOURNAL

Reactive Oxygen Species in Peripheral Blood and Sputum Neutrophils During Bacterial and Nonbacterial Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Mindaugas Vaitkus et al.   INFLAMMATION

Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: The neutrophil as an immunotherapeutic target

(2013) James A. Stockley et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evaluation of C-Reactive Protein Before and On-Treatment as a Predictor of Benefit of Atorvastatin

(2013) Peter S. Sever et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

(2013)   LANCET

Comorbidities and Risk of Mortality in Patients with Chronic Obstructive Pulmonary Disease

(2012) Miguel Divo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

(2012) S. Sangaletti et al.   BLOOD

Multiple Roles for Neutrophils in Atherosclerosis

(2012) Oliver Soehnlein   CIRCULATION RESEARCH

Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency

(2012) Helen Stone et al.   EUROPEAN RESPIRATORY JOURNAL

Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity

(2012) Angélica Aparecida Antoniellis Silveira et al.   INFLAMMATION RESEARCH

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Behavioral and Structural Differences in Migrating Peripheral Neutrophils from Patients with Chronic Obstructive Pulmonary Disease

(2011) Elizabeth Sapey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The impact of high-dose statin therapy on transendothelial neutrophil migration and serum cholesterol levels in healthy male volunteers

(2011) Aisling Kinsella et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Control of Secondary Granule Release in Neutrophils by Ral GTPase

(2011) Celia X.-J. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins Enhance Formation of Phagocyte Extracellular Traps

(2010) Ohn A. Chow et al.   Cell Host & Microbe

Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity

(2010) C. Antoniades et al.   CIRCULATION

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis

(2010) O. P Kurmi et al.   THORAX

Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care

(2010) J. R. Feary et al.   THORAX

Statins inhibit matrix metalloproteinase release from human lung fibroblasts

(2009) K. Kamio et al.   EUROPEAN RESPIRATORY JOURNAL

Chemotaxis: finding the way forward with Dictyostelium

(2009) Jason S. King et al.   TRENDS IN CELL BIOLOGY

The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis

(2009) F. Wang   Cold Spring Harbor Perspectives in Biology

Persistence of oxidant and protease burden in the airways after smoking cessation

(2009) Noora Louhelainen et al.   BMC Pulmonary Medicine

Effect of Statin Therapy on Mortality in Patients With Peripheral Arterial Disease and Comparison of Those With Versus Without Associated Chronic Obstructive Pulmonary Disease

(2008) Yvette R.B.M. van Gestel et al.   AMERICAN JOURNAL OF CARDIOLOGY

Relationship of Admission Neutrophil Count to Microvascular Injury, Left Ventricular Dilation, and Long-Term Outcome in Patients Treated With Primary Angioplasty for Acute Myocardial Infarction

(2008) Takefumi Takahashi et al.   CIRCULATION JOURNAL

Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD

(2008) D. M. Mannino et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE