Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

(2012) Ling Li et al.   MOLECULAR NEUROBIOLOGY

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

(2011) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

Pitavastatin decreases tau levels via the inactivation of Rho/ROCK

(2011) Tadanori Hamano et al.   NEUROBIOLOGY OF AGING

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

(2011) R.A. Mans et al.   NEUROSCIENCE

Control of synapse development and plasticity by Rho GTPase regulatory proteins

(2011) Kimberley F. Tolias et al.   PROGRESS IN NEUROBIOLOGY

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia

(2010) Angel Céspedes-Rubio et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

(2010) Xiaojing Ye et al.   NEURON

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

(2009) Pi-Lin Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

(2009) Gunter P. Eckert et al.   NEUROBIOLOGY OF DISEASE

Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice

(2009) R.A. Mans et al.   NEUROSCIENCE

Rac1 changes the substrate specificity of γ-secretase between amyloid precursor protein and Notch1

(2008) Jung Hyun Boo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ

(2007) Yan Zhou et al.   FASEB JOURNAL