Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?

Quantitative Changes in the Mitochondrial Proteome from Subjects with Mild Cognitive Impairment, Early Stage, and Late Stage Alzheimer's Disease

(2017) Bert C. Lynn et al.   JOURNAL OF ALZHEIMERS DISEASE

CSF Levels of Heart Fatty Acid Binding Protein are Altered During Early Phases of Alzheimer's Disease

(2017) Davide Chiasserini et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

(2015) Hlin Kvartsberg et al.   Alzheimers & Dementia

Explorative and targeted neuroproteomics in Alzheimer's disease

(2015) Ann Brinkmalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease

(2015) Masanori Itakura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease: a systematic review and meta-analysis of cohort studies

(2015) Jie-Qiong Li et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cognitive and Brain Profiles Associated with Current Neuroimaging Biomarkers of Preclinical Alzheimer's Disease

(2015) F. L. Besson et al.   JOURNAL OF NEUROSCIENCE

SWATH analysis of the synaptic proteome in Alzheimer's disease

(2015) Rachel Yoon Kyung Chang et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid biomarkers in Alzheimer's disease

(2015) Kaj Blennow et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

The critical need for defining preclinical biomarkers in Alzheimer's disease

(2014) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Biomarkers in Alzheimer’s Disease Analysis by Mass Spectrometry-Based Proteomics

(2014) Yahui Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantification of the Brain Proteome in Alzheimer’s Disease Using Multiplexed Mass Spectrometry

(2014) Sravani Musunuri et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative proteomics reveals that PEA15 regulates astroglial Aβ phagocytosis in an Alzheimer's disease mouse model

(2014) Junniao Lv et al.   Journal of Proteomics

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

(2014) Ann Brinkmalm et al.   Molecular Neurodegeneration

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

(2014) Alberto Lleó et al.   Nature Reviews Neurology

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology

(2014) Rosie K. A. Bunton-Stasyshyn et al.   NEUROSCIENTIST

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins

(2014) Eric B. Dammer et al.   PROTEOMICS

Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage

(2014) Dongxu Zhai et al.   Molecular Brain

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Neuronal Ubiquitin Homeostasis

(2013) Jada Hallengren et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Redox proteomics: from protein modifications to cellular dysfunction and disease

(2013) D. Allan Butterfield et al.   MASS SPECTROMETRY REVIEWS

Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration

(2013) Rahul S Desikan et al.   Molecular Neurodegeneration

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative Label-Free Proteomics for Discovery of Biomarkers in Cerebrospinal Fluid: Assessment of Technical and Inter-Individual Variation

(2013) Richard J. Perrin et al.   PLoS One

Phosphoproteome analysis of an early onset mouse model (TgCRND8) of Alzheimer's disease reveals temporal changes in neuronal and glia signaling pathways

(2013) Fangjun Wang et al.   PROTEOMICS

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Do Proteomics Analyses Provide Insights into Reduced Oxidative Stress in the Brain of an Alzheimer Disease Transgenic Mouse Model with an M631L Amyloid Precursor Protein Substitution and Thereby the Importance of Amyloid-Beta-Resident Methionine 35 in Alzheimer Disease Pathogenesis?

(2012) Rukhsana Sultana et al.   ANTIOXIDANTS & REDOX SIGNALING

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer’s disease patients

(2012) Saadia Zahid et al.   JOURNAL OF NEUROCHEMISTRY

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains

(2012) Victor P. Andreev et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

(2012) Michael A Gillette et al.   NATURE METHODS

Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis

(2012) Masaoki Takano et al.   NEUROSCIENCE LETTERS

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease

(2012) Laura E. Donovan et al.   Proteomics Clinical Applications

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution

(2011) Maria Merkulova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Collapsin Response Mediator Proteins (CRMPs) Are a New Class of Microtubule-associated Protein (MAP) That Selectively Interacts with Assembled Microtubules via a Taxol-sensitive Binding Interaction

(2011) Pao-Chun Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

(2011) Rukhsana Sultana et al.   Journal of Proteomics

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects

(2011) Fabio Di Domenico et al.   Journal of Proteomics

Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease

(2011) Jose L. Chou et al.   Journal of Proteomics

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

(2011) Madhav Thambisetty et al.   NEUROIMAGE

Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor proteinΞ

(2011) R.A.S. Robinson et al.   NEUROSCIENCE

Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease

(2011) Natalie A. Twine et al.   PLoS One

Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

(2011) Richard J. Perrin et al.   PLoS One

Peptide Fingerprinting of Alzheimer's Disease in Cerebrospinal Fluid: Identification and Prospective Evaluation of New Synaptic Biomarkers

(2011) Holger Jahn et al.   PLoS One

Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: Insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive

(2011) Renã A. S. Robinson et al.   PROTEOMICS

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage

(2010) Rajkumar Tulsawani et al.   BMC NEUROSCIENCE

Autophagy and misfolded proteins in neurodegeneration

(2010) Daniel J. Metcalf et al.   EXPERIMENTAL NEUROLOGY

Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ

(2010) Parvathi Rudrabhatla et al.   FASEB JOURNAL

Neurogranin, a link between calcium/calmodulin and protein kinase C signaling in synaptic plasticity

(2010) F. Javier Díez-Guerra   IUBMB LIFE

Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons

(2010) Michael C Chang et al.   NATURE NEUROSCIENCE

Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders

(2010) A. Bartolomucci et al.   NEUROSCIENCE

Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease

(2010) D Ciavardelli et al.   Cell Death & Disease

Identifying Early Markers of Alzheimer's Disease using Quantitative Multiplex Proteomic Immunoassay Panels

(2009) Holly D. Soares et al.   Annals of the New York Academy of Sciences

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

(2009) Tanea T. Reed et al.   BRAIN RESEARCH

Rapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the APOE ε4/ε4 Genotype

(2009) Elin S. Blom et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity

(2009) Kajsa Sämgård et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

An update on clinical proteomics in Alzheimer’s research

(2009) Minna A. Korolainen et al.   JOURNAL OF NEUROCHEMISTRY

Proteomics Analysis Reveals Novel Components in the Detergent-Insoluble Subproteome in Alzheimer’s Disease

(2009) Yair M. Gozal et al.   JOURNAL OF PROTEOME RESEARCH

Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study

(2009) Pieter Jelle Visser et al.   LANCET NEUROLOGY

Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease

(2009) Josef Marksteiner et al.   NEUROBIOLOGY OF AGING

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis

(2008) E. J. Burton et al.   BRAIN

Disease State, Age, Sex, and Post-Mortem Time-Dependent Expression of Proteins in AD vs. Control Frontal Cortex Brain Samples

(2008) T. Muller et al.   Current Alzheimer Research

Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene

(2008) Mikako Sakurai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Phosphoproteomic Analysis of Human Brain by Calcium Phosphate Precipitation and Mass Spectrometry

(2008) Qiangwei Xia et al.   JOURNAL OF PROTEOME RESEARCH

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

(2008) Nilkantha Sen et al.   NATURE CELL BIOLOGY

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

(2008) L. Mosconi et al.   NEUROLOGY

iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

(2008) Bronwen Martin et al.   PLoS One

Proteomics of human cerebral microdialysate: From detection of biomarkers to clinical application

(2008) Martin H. Maurer et al.   Proteomics Clinical Applications

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING