Protein prenylation: unique fats make their mark on biology

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

(2015) A. D. Cox et al.   CLINICAL CANCER RESEARCH

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

(2015) Christopher Koh et al.   LANCET INFECTIOUS DISEASES

An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

(2014) Hiu Yeung Lau et al.   CANCER BIOLOGY & THERAPY

Progeria: A Paradigm for Translational Medicine

(2014) Leslie B. Gordon et al.   CELL

Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome

(2014) Leslie B. Gordon et al.   CIRCULATION

Mutational Analysis of the Integral Membrane Methyltransferase Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Reveals Potential Substrate Binding Sites

(2014) Melinda M. Diver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAXMotif

(2014) Nathan J. Schuld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins

(2014) Charuta C. Palsuledesai et al.   Molecular BioSystems

Inhibiting Geranylgeranylation Increases Neurite Branching and Differentially Activates Cofilin in Cell Bodies and Growth Cones

(2014) Filsy Samuel et al.   MOLECULAR NEUROBIOLOGY

Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease

(2014) David A. Hottman et al.   MOLECULAR NEUROBIOLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

YAP and TAZ under metabolic control

(2014) Katharine H. Wrighton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism

(2014) J T Teh et al.   ONCOGENE

Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

(2013) Vanessa P. Houde et al.   BIOCHEMICAL JOURNAL

Topology of the Yeast Ras Converting Enzyme As Inferred from Cysteine Accessibility Studies

(2013) Emily R. Hildebrandt et al.   BIOCHEMISTRY

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

(2013) Philippe Riou et al.   CELL

Control of RhoA Methylation by Carboxylesterase I

(2013) Ian Cushman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease

(2013) Shaowu Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression

(2013) Helen Court et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Novel Prenyl and Palmitoyl Modification at the CaaX Motif of Cdc42 That Regulates RhoGDI Binding

(2013) A. Nishimura et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

(2013) Ioannis Manolaridis et al.   NATURE

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Transformation by HrasG12V is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition

(2013) X Chen et al.   ONCOGENE

Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

(2013) M. X. Ibrahim et al.   SCIENCE

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

(2013) E. Ntantie et al.   Science Signaling

Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors

(2013) Stephen A. Adam et al.   Nucleus

Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury

(2012) Zirak Hasan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions

(2012) Elaina A Zverina et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Prenylation of Rho G-Proteins: a Novel Mechanism Regulating Gene Expression and Protein Stability in Human Trabecular Meshwork Cells

(2012) Evan B. Stubbs et al.   MOLECULAR NEUROBIOLOGY

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

A Role for Rac3 GTPase in the Regulation of Autophagy

(2011) Wan Long Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

(2011) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery and SAR of Methylated Tetrahydropyranyl Derivatives as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (ICMT)

(2011) Weston R. Judd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase ICMT

(2011) Jing Yang et al.   MOLECULAR CELL

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments

(2011) J. R. Christiansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

(2011) Joel A. Bergman et al.   ACS Medicinal Chemistry Letters

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma Membrane

(2010) Pinkesh Bhagatji et al.   BIOPHYSICAL JOURNAL

Statin myopathy: a review of recent progress

(2010) Andrew L Mammen et al.   CURRENT OPINION IN RHEUMATOLOGY

Farnesyltransferase inhibitors: where are we now?

(2010) Apostolia Maria Tsimberidou et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

(2010) Shao H. Yang et al.   HUMAN MOLECULAR GENETICS

Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p

(2010) Amy M. Griggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization

(2010) Tracy J. Berg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells

(2010) K. M. Sane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The chemical toolbox for monitoring protein fatty acylation and prenylation

(2010) Rami N Hannoush et al.   Nature Chemical Biology

Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead

(2010) Heiner Wedemeyer et al.   Nature Reviews Gastroenterology & Hepatology

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

(2010) Xiaojing Ye et al.   NEURON

Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth

(2010) M Wang et al.   ONCOGENE

Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins

(2010) T T Zhao et al.   ONCOGENE

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTPases involved in vesicular trafficking: Structures and mechanisms

(2010) Aymelt Itzen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Farnesyltransferase inhibitors-induced autophagy: Alternative mechanisms?

(2009) Jingxuan Pan et al.   Autophagy

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

(2009) Michael A. Hast et al.   CHEMISTRY & BIOLOGY

Role of Isoprenylcysteine Carboxylmethyltransferase-catalyzed Methylation in Rho Function and Migration

(2009) Ian Cushman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes with Distinct Sequence Selectivities

(2009) James L. Hougland et al.   JOURNAL OF MOLECULAR BIOLOGY

Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe

(2009) L. P. Wright et al.   MOLECULAR AND CELLULAR BIOLOGY

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

(2009) J. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Observation of an Efimov-like trimer resonance in ultracold atom–dimer scattering

(2009) S. Knoop et al.   Nature Physics

Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling

(2009) A B Hanker et al.   ONCOGENE

Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease

(2008) A. M. Wahlstrom et al.   BLOOD

Autophagy in aging, disease and death: the true identity of a cell death impostor

(2008) B Levine et al.   CELL DEATH AND DIFFERENTIATION

Farnesyltransferase Inhibitors: A Detailed Chemical View on an Elusive Biological Problem

(2008) Sergio Sousa et al.   CURRENT MEDICINAL CHEMISTRY

Liver prenylated methylated protein methyl esterase is the same enzyme assus scrofa carboxylesterase

(2008) Onovughode T. Oboh et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization

(2008) Cristina Lopez-Alcalá et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells

(2008) Mei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isoprenylcysteine Methylation and Demethylation Regulate Abscisic Acid Signaling in Arabidopsis

(2008) D. H. Huizinga et al.   PLANT CELL