Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence

(2012) P. Eikelenboom et al.   Current Alzheimer Research

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

Pharmacology of bisphosphonates

(2011) Serge Cremers et al.   BONE

Pitavastatin Calcium: Clinical Review of a New Antihyperlipidemic Medication

(2011) Laurie L. Yee et al.   CLINICAL THERAPEUTICS

The three new pathways leading to Alzheimer's disease

(2011) K. Morgan   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

(2011) R.A. Mans et al.   NEUROSCIENCE

Control of synapse development and plasticity by Rho GTPase regulatory proteins

(2011) Kimberley F. Tolias et al.   PROGRESS IN NEUROBIOLOGY

Simvastatin improves learning and memory in control but not in olfactory bulbectomized rats

(2011) Tessa N. Douma et al.   PSYCHOPHARMACOLOGY

posters F: Phase 1 and 2 studies

(2010)   ANNALS OF ONCOLOGY

Progeria, the nucleolus and farnesyltransferase inhibitors

(2010) Ishita S. Mehta et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Biochemical and molecular mechanisms of action of bisphosphonates

(2010) Michael J. Rogers et al.   BONE

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: Synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator

(2010) Paul A. Lapchak et al.   BRAIN RESEARCH

Simvastatin enhances immune responses to Aβ vaccination and attenuates vaccination-induced behavioral alterations

(2010) Jinghong Kou et al.   BRAIN RESEARCH

Evaluation of Alkyne-Modified Isoprenoids as Chemical Reporters of Protein Prenylation

(2010) Amanda J. DeGraw et al.   Chemical Biology & Drug Design

Bisphosphonates: Molecular Mechanisms of Action and Effects on Bone Cells, Monocytes and Macrophages

(2010) A. J. Roelofs et al.   CURRENT PHARMACEUTICAL DESIGN

The role of Rho GTPase proteins in CNS neuronal migration

(2010) Eve-Ellen Govek et al.   Developmental Neurobiology

Farnesyltransferase inhibitors: where are we now?

(2010) Apostolia Maria Tsimberidou et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia

(2010) Angel Céspedes-Rubio et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Tagging-via-substrate Approach to Detect the Farnesylated Proteome Using Two-dimensional Electrophoresis Coupled with Western Blotting

(2010) Fredrick O. Onono et al.   MOLECULAR & CELLULAR PROTEOMICS

Modulation of Cholesterol, Farnesylpyrophosphate, and Geranylgeranylpyrophosphate in Neuroblastoma SH-SY5Y-APP695 Cells: Impact on Amyloid Beta-Protein Production

(2010) Gero P. Hooff et al.   MOLECULAR NEUROBIOLOGY

The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal Pathways

(2010) C.-K. Kim et al.   MOLECULAR PHARMACOLOGY

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

(2010) Wolfgang Jahnke et al.   Nature Chemical Biology

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

(2010) Xiaojing Ye et al.   NEURON

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel approach to tag and identify geranylgeranylated proteins

(2009) Lai N. Chan et al.   ELECTROPHORESIS

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

(2009) Stacey Fuller et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

(2009) Uyen T T Nguyen et al.   Nature Chemical Biology

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

(2009) Gunter P. Eckert et al.   NEUROBIOLOGY OF DISEASE

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice

(2009) R.A. Mans et al.   NEUROSCIENCE

Membrane-associated farnesylated UCH-L1 promotes  -synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

(2009) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk factors for dementia in the epidemiological study of Munguialde County (Basque Country-Spain)

(2008) Manuel Fernández Martínez et al.   BMC Neurology

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA

Inhibition of Rho Family Functions by Lovastatin Promotes Myelin Repair in Ameliorating Experimental Autoimmune Encephalomyelitis

(2008) A. S. Paintlia et al.   MOLECULAR PHARMACOLOGY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner

(2008) Madhuvanthi Kannan et al.   NEUROBIOLOGY OF AGING

Essential Role of TGF-β/Smad Pathway on Statin Dependent Vascular Smooth Muscle Cell Regulation

(2008) Juan Rodríguez-Vita et al.   PLoS One

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

(2008) B. C. Capell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ

(2007) Yan Zhou et al.   FASEB JOURNAL