Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function

Stromal cells and stem cells in clinical bone regeneration

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Crif1 Promotes Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells After Irradiation by Modulating the PKA/CREB Signaling Pathway

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Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trial

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Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells

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mTOR is a key modulator of ageing and age-related disease

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Charity begins at home: non-coding RNA functions in DNA repair

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Differentiation-Related Response to DNA Breaks in Human Mesenchymal Stem Cells

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Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments

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A Small Molecule Modulator of Prion Protein Increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, and Engraftment to Bone Marrow in NOD/SCID Mice

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The relationship between the chemistry and biological activity of the bisphosphonates

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Bisphosphonates: The first 40years

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GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

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Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells

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Biochemical and molecular mechanisms of action of bisphosphonates

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Zoledronic acid use in cancer patients

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Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

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Osteonecrosis of the Jaw: Effect of Bisphosphonate Type, Local Concentration, and Acidic Milieu on the Pathomechanism

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Radiation effects on bone healing and reconstruction: interpretation of the literature

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Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation

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Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

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FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

FoxO3 Regulates Neural Stem Cell Homeostasis

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Potential mediators of the mortality reduction with zoledronic acid after hip fracture

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A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

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Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

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FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging

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Palomid 529, a Novel Small-Molecule Drug, Is a TORC1/TORC2 Inhibitor That Reduces Tumor Growth, Tumor Angiogenesis, and Vascular Permeability

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Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest

(2008) Keiyo Takubo et al.   Cell Stem Cell

Functional interaction between FOXO3a and ATM regulates DNA damage response

(2008) Wen-Bin Tsai et al.   NATURE CELL BIOLOGY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

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Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

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