Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

(2012) Yen-Chih Wang et al.   CHEMICAL COMMUNICATIONS

Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

(2012) Veronica M. Zhang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Intrinsically Unstructured Domain 3 of Hepatitis C Virus NS5A Forms a “Fuzzy Complex” with VAPB-MSP Domain Which Carries ALS-Causing Mutations

(2012) Garvita Gupta et al.   PLoS One

Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma

(2012) Wei-Wei Dong   WORLD JOURNAL OF GASTROENTEROLOGY

Structure-Guided Development of Selective RabGGTase Inhibitors

(2011) Robin S. Bon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lamin A, farnesylation and aging

(2011) Sita Reddy et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of Ras for cancer treatment: the search continues

(2011) Antonio T Baines et al.   Future Medicinal Chemistry

Mechanisms of Premature Vascular Aging in Children With Hutchinson-Gilford Progeria Syndrome

(2011) Marie Gerhard-Herman et al.   HYPERTENSION

Structures ofCryptococcus neoformansProtein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

(2011) Michael A. Hast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Mechanistic Dichotomy of the Protein Farnesyltransferase Peptide Substrates CVIM and CVLS

(2011) Yue Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PEG-IFN for the treatment of hepatitis D

(2011) Alessia Ciancio et al.   Nature Reviews Gastroenterology & Hepatology

Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry

(2010) Alexandra F. H. Berry et al.   CHEMBIOCHEM

Evaluation of Alkyne-Modified Isoprenoids as Chemical Reporters of Protein Prenylation

(2010) Amanda J. DeGraw et al.   Chemical Biology & Drug Design

Second Generation Analogues of the Cancer Drug Clinical Candidate Tipifarnib for Anti-Chagas Disease Drug Discovery

(2010) James M. Kraus et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Tagging-via-substrate Approach to Detect the Farnesylated Proteome Using Two-dimensional Electrophoresis Coupled with Western Blotting

(2010) Fredrick O. Onono et al.   MOLECULAR & CELLULAR PROTEOMICS

Alkynyl-farnesol reporters for detection ofproteinS-prenylation in cells

(2010) Guillaume Charron et al.   Molecular BioSystems

Context-Dependent Substrate Recognition by Protein Farnesyltransferase†

(2009) James L. Hougland et al.   BIOCHEMISTRY

Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues

(2009) Stéphanie Duez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

(2009) Michael A. Hast et al.   CHEMISTRY & BIOLOGY

A novel approach to tag and identify geranylgeranylated proteins

(2009) Lai N. Chan et al.   ELECTROPHORESIS

Unraveling the Catalytic Pathway of Metalloenzyme Farnesyltransferase through QM/MM Computation

(2009) Ming-Hsun Ho et al.   Journal of Chemical Theory and Computation

Laminopathies and the long strange trip from basic cell biology to therapy

(2009) Howard J. Worman et al.   JOURNAL OF CLINICAL INVESTIGATION

Prelamin A prenylation and the treatment of progeria: Fig. 1.

(2009) Howard J. Worman   JOURNAL OF LIPID RESEARCH

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

(2009) Shao H. Yang et al.   JOURNAL OF LIPID RESEARCH

Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes with Distinct Sequence Selectivities

(2009) James L. Hougland et al.   JOURNAL OF MOLECULAR BIOLOGY

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

(2009) Uyen T T Nguyen et al.   Nature Chemical Biology

Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase–Inhibitor Complex

(2008) Zhong Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

(2008) Andrew J. Wiemer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structures of RabGGTase–substrate/product complexes provide insights into the evolution of protein prenylation

(2008) Zhong Guo et al.   EMBO JOURNAL

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase

(2008) Rudi A. Baron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds

(2008) Masaru Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure−Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation

(2008) Steven Fletcher et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Oxotetrahydroquinoline-Based Antimalarials with High Potency and Metabolic Stability

(2008) Vivek J. Bulbule et al.   JOURNAL OF MEDICINAL CHEMISTRY

“Inject-Mix-React-Separate-and-Quantitate” (IMReSQ) Method for Screening Enzyme Inhibitors

(2008) Edmund Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson–Gilford progeria syndrome mutation

(2007) S YANG   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials

(2007) Srinivas Olepu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS