Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease

(2013) Shaowu Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Intraneuronally injected amyloid beta inhibits long-term potentiation in rat hippocampal slices

(2012) Izumi Nomura et al.   JOURNAL OF NEUROPHYSIOLOGY

 -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

(2012) A. Mohamed et al.   JOURNAL OF NEUROSCIENCE

Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

(2012) Ling Li et al.   MOLECULAR NEUROBIOLOGY

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Pitavastatin decreases tau levels via the inactivation of Rho/ROCK

(2011) Tadanori Hamano et al.   NEUROBIOLOGY OF AGING

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

(2011) R.A. Mans et al.   NEUROSCIENCE

Control of synapse development and plasticity by Rho GTPase regulatory proteins

(2011) Kimberley F. Tolias et al.   PROGRESS IN NEUROBIOLOGY

The role of APP proteolytic processing in lipid metabolism

(2011) Marcus O. W. Grimm et al.   EXPERIMENTAL BRAIN RESEARCH

Synaptic Plasticity, a Symphony in GEF

(2010) Drew D. Kiraly et al.   ACS Chemical Neuroscience

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synaptic stability and plasticity in a floating world

(2010) Kimberly Gerrow et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of Rho GTPase proteins in CNS neuronal migration

(2010) Eve-Ellen Govek et al.   Developmental Neurobiology

p120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia

(2010) Angel Céspedes-Rubio et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

(2010) Xiaojing Ye et al.   NEURON

Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders

(2010) Ruth L. Stornetta et al.   NEUROSCIENTIST

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

(2009) Pi-Lin Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

(2009) Gunter P. Eckert et al.   NEUROBIOLOGY OF DISEASE

Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice

(2009) R.A. Mans et al.   NEUROSCIENCE

Spike Timing–Dependent Plasticity: A Hebbian Learning Rule

(2008) Natalia Caporale et al.   Annual Review of Neuroscience

Rac1 changes the substrate specificity of γ-secretase between amyloid precursor protein and Notch1

(2008) Jung Hyun Boo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

(2008) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis

(2008) X.-P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ

(2007) Yan Zhou et al.   FASEB JOURNAL