The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines

‘Nano–in–nano’ hybrid liposomes increase target specificity and gene silencing efficiency in breast cancer induced SCID mice

(2017) Dhiraj Bhavsar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Using zebrafish models of leukemia to streamline drug screening and discovery

(2017) Adam P. Deveau et al.   EXPERIMENTAL HEMATOLOGY

Progress in nonviral gene therapy for breast cancer and what comes next?

(2017) Giulia Bottai et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Zebrafish xenograft models of cancer and metastasis for drug discovery

(2017) Hannah K Brown et al.   Expert Opinion on Drug Discovery

Dinuclear RuII(bipy)2 Derivatives: Structural, Biological, and in Vivo Zebrafish Toxicity Evaluation

(2017) Oscar A. Lenis-Rojas et al.   INORGANIC CHEMISTRY

Chitosan-palmitic acid based polymeric micelles as promising carrier for circumventing pharmacokinetic and drug delivery concerns of tamoxifen

(2017) Nagarani Thotakura et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer

(2017) Jinliang Chen et al.   International Journal of Nanomedicine

Nanomedicinal products: a survey on specific toxicity and side effects

(2017) Walter Brand et al.   International Journal of Nanomedicine

Penetration of blood–brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system

(2017) Dan Zou et al.   International Journal of Nanomedicine

Protein corona: a new approach for nanomedicine design

(2017) Van Hong Nguyen et al.   International Journal of Nanomedicine

A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C

(2017) Khaldoun Almhanna et al.   INVESTIGATIONAL NEW DRUGS

PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo

(2017) Gudrun Aldrian et al.   JOURNAL OF CONTROLLED RELEASE

Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo

(2017) Sandro Sieber et al.   JOURNAL OF CONTROLLED RELEASE

Genome editing using CRISPR/Cas9-based knock-in approaches in zebrafish

(2017) Shahad Albadri et al.   METHODS

Folate-targeted polymeric micelles loaded with superparamagnetic iron oxide as a contrast agent for magnetic resonance imaging of a human tongue cancer cell line

(2017) Min-Yi Cui et al.   Molecular Medicine Reports

Assessment of the permeability and toxicity of polymeric nanocapsules using the zebrafish model

(2017) Carmen Teijeiro-Valiño et al.   Nanomedicine

Modified nanoparticle mediated IL-12 immunogene therapy for colon cancer

(2017) Xiaoxiao Liu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Polyanionic carbosilane dendrimers prevent hepatitis C virus infection in cell culture

(2017) Daniel Sepúlveda-Crespo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model

(2017) L D’Abundo et al.   ONCOGENE

Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy

(2017) Eameema Muntimadugu et al.   PHARMACOLOGICAL RESEARCH

From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics

(2017) Ellen van Rooijen et al.   Pigment Cell & Melanoma Research

Multifunctional Nucleus-targeting Nanoparticles with Ultra-high Gene Transfection Efficiency for In Vivo Gene Therapy

(2017) Ling Li et al.   Theranostics

Polymeric micelles with dual thermal and reactive oxygen species (ROS)-responsiveness for inflammatory cancer cell delivery

(2017) Meiqiong Tang et al.   JOURNAL OF NANOBIOTECHNOLOGY

MiR-101 and doxorubicin codelivered by liposomes suppressing malignant properties of hepatocellular carcinoma

(2017) Fei Xu et al.   Cancer Medicine

Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

(2017) et al.   Genes

Zebrafish Xenograft: An Evolutionary Experiment in Tumour Biology

(2017) Rachael A. Wyatt et al.   Genes

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

(2017) Milton Cordeiro et al.   Nanomaterials

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

Towards clinically translatable in vivo nanodiagnostics

(2017) Seung-min Park et al.   Nature Reviews Materials

Quo natas, Danio?—Recent Progress in Modeling Cancer in Zebrafish

(2017) Stefanie Kirchberger et al.   Frontiers in Oncology

Combined Tumor- and Neovascular-“Dual Targeting” Gene/Chemo-Therapy Suppresses Tumor Growth and Angiogenesis

(2016) Bei Xu et al.   ACS Applied Materials & Interfaces

Application of Coiled Coil Peptides in Liposomal Anticancer Drug Delivery Using a Zebrafish Xenograft Model

(2016) Jian Yang et al.   ACS Nano

Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos

(2016) O. A. Lenis-Rojas et al.   DALTON TRANSACTIONS

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies

(2016) Michelle Dang et al.   Disease Models & Mechanisms

Multifaceted toxicity assessment of catalyst composites in transgenic zebrafish embryos

(2016) Gun Hyuk Jang et al.   ENVIRONMENTAL POLLUTION

Combined toxicity of silica nanoparticles and methylmercury on cardiovascular system in zebrafish (Danio rerio) embryos

(2016) Junchao Duan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Applications of lipid nanoparticles in gene therapy

(2016) Ana del Pozo-Rodríguez et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Non-viral nucleic acid delivery methods

(2016) Igor Slivac et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Vectors and strategies for nonviral cancer gene therapy

(2016) Jessica Pahle et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-β1–42-injected mice

(2016) Yanqiang Zhong et al.   International Journal of Nanomedicine

Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration

(2016) Xiangrong Song et al.   International Journal of Nanomedicine

A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

(2016) Christina Giannakou et al.   International Journal of Nanomedicine

Efficient inhibition of ovarian cancer by degradable nanoparticle-delivered survivin T34A gene

(2016) Li Luo et al.   International Journal of Nanomedicine

Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells

(2016) Emiliano Cocco et al.   MOLECULAR CANCER THERAPEUTICS

Lipid-based nanosystems for CD44 targeting in cancer treatment: recent significant advances, ongoing challenges and unmet needs

(2016) Thais Leite Nascimento et al.   Nanomedicine

Zebrafish as a model system for characterization of nanoparticles against cancer

(2016) Lasse Evensen et al.   Nanoscale

Advancements in zebrafish applications for 21st century toxicology

(2016) Gloria R. Garcia et al.   PHARMACOLOGY & THERAPEUTICS

Zebrafish Genome Engineering Using the CRISPR–Cas9 System

(2016) Mingyu Li et al.   TRENDS IN GENETICS

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

High throughput toxicity screening and intracellular detection of nanomaterials

(2016) Andrew R. Collins et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Nanoparticles and radiotracers: advances toward radionanomedicine

(2016) Edwin C. Pratt et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Developing a Novel Embryo–Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics

(2016) Leah Christine Wehmas et al.   Zebrafish

WT1 shRNA delivery using transferrin-conjugated PEG liposomes in an in vivo model of melanoma

(2016) Santiago Saavedra-Alonso et al.   Experimental and Therapeutic Medicine

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

(2016) Qin Tang et al.   Nature Communications

Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model

(2016) María Roel et al.   Oncotarget

MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase

(2016) Recep Bayraktar et al.   Oncotarget

Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish

(2016) Ye Zhao et al.   Scientific Reports

Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial

(2016) Shady Kotb et al.   Theranostics

Nanoparticles for Cancer Targeting: Current and Future Directions

(2016) Suryakanta Swain et al.   Current Drug Delivery

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

(2016) Chiranjib Chakraborty et al.   JOURNAL OF NANOBIOTECHNOLOGY

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

(2016) Justin B Lee et al.   Molecular Therapy-Nucleic Acids

Modified Nanoemulsions with Iron Oxide for Magnetic Resonance Imaging

(2016) Yongyi Fan et al.   Nanomaterials

Does Nanomedicine Have a Delivery Problem?

(2016) Michael Torrice   ACS Central Science

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

MicroRNA Targeting to Modulate Tumor Microenvironment

(2016) Praneeth R. Kuninty et al.   Frontiers in Oncology

Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors

(2015) Huiyuan Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Enantioselective developmental toxicity and immunotoxicity of pyraclofos toward zebrafish (Danio rerio)

(2015) Shulin Zhuang et al.   AQUATIC TOXICOLOGY

Applications of nanoparticles for diagnosis and therapy of cancer

(2015) S C Baetke et al.   BRITISH JOURNAL OF RADIOLOGY

In vivo toxicity assessment of angiogenesis and the live distribution of nano-graphene oxide and its PEGylated derivatives using the developing zebrafish embryo

(2015) Jinyoung Jeong et al.   CARBON

Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos

(2015) Cristina Penas et al.   CHEMBIOCHEM

The melanocyte lineage in development and disease

(2015) R. L. Mort et al.   DEVELOPMENT

Assessment of immunotoxicity of dibutyl phthalate using live zebrafish embryos

(2015) Hai Xu et al.   FISH & SHELLFISH IMMUNOLOGY

The promise of zebrafish as a chemical screening tool in cancer therapy

(2015) Xiayang Xie et al.   Future Medicinal Chemistry

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

A fresh look at zebrafish from the perspective of cancer research

(2015) Shuai Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

(2015) Bryan Harper et al.   JOURNAL OF NANOPARTICLE RESEARCH

Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis

(2015) Jie Chang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Nanoparticles as drug carriers: current issues within vitrotesting

(2015) Maryam Alsadat Shetab Boushehri et al.   Nanomedicine

A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer

(2015) Maria de la Fuente et al.   Nanomedicine-Nanotechnology Biology and Medicine

Design considerations for nanotherapeutics in oncology

(2015) Triantafyllos Stylianopoulos et al.   Nanomedicine-Nanotechnology Biology and Medicine

Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish

(2015) Carina Beatrice Vibe et al.   Nanotoxicology

Rapid reverse genetic screening using CRISPR in zebrafish

(2015) Arish N Shah et al.   NATURE METHODS

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Nanoparticles as Drug Delivery System against Tuberculosis in Zebrafish Embryos: Direct Visualization and Treatment

(2014) Federico Fenaroli et al.   ACS Nano

Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development

(2014) J. Wang et al.   CANCER RESEARCH

Optimisation of Synthetic Vector Systems for Cancer Gene Therapy – The Role of the Excess of Cationic Dendrimer Under Physiological Conditions

(2014) M.J. Santander-Ortega et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system

(2014) U. Irion et al.   DEVELOPMENT

Zebrafish as a model to assess cancer heterogeneity, progression and relapse

(2014) J. S. Blackburn et al.   Disease Models & Mechanisms

Zebrafish models in translational research: tipping the scales toward advancements in human health

(2014) J. B. Phillips et al.   Disease Models & Mechanisms

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

Mechanism of TiO2nanoparticle-induced neurotoxicity in zebrafish (Danio rerio)

(2014) Lei Sheng et al.   ENVIRONMENTAL TOXICOLOGY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Docetaxel in cationic lipid nanocapsules for enhancedin vivoactivity

(2014) Ankitkumar S. Jain et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Quantitative Phenotyping-Based In Vivo Chemical Screening in a Zebrafish Model of Leukemia Stem Cell Xenotransplantation

(2014) Beibei Zhang et al.   PLoS One

Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors

(2014) Beibei Zhang et al.   TUMOR BIOLOGY

Whole adult organism transcriptional profiling of acute metal exposures in male Zebrafish

(2014) Naissan Hussainzada et al.   BMC Pharmacology & Toxicology

Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion

(2013) Hildegonda P.H. Naber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zebrafish embryo as a tool to study tumor/endothelial cell cross-talk

(2013) Chiara Tobia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nanooncology: The future of cancer diagnosis and therapy

(2013) Avnesh S. Thakor et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Integrating zebrafish toxicology and nanoscience for safer product development

(2013) Ki-Tae Kim et al.   GREEN CHEMISTRY

The role of immune-related myeloid cells in angiogenesis

(2013) Sarah E.J. Chambers et al.   IMMUNOBIOLOGY

Non-mammalian vertebrate embryos as models in nanomedicine

(2013) Martina Giannaccini et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanistic insights into the effect of nanoparticles on zebrafish hatch

(2013) Kimberly Jessica Ong et al.   Nanotoxicology

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

A Novel Zebrafish Xenotransplantation Model for Study of Glioma Stem Cell Invasion

(2013) Xiao-jun Yang et al.   PLoS One

Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion

(2013) Nitu Bansal et al.   PROSTATE

Of fish and men: using zebrafish to fight human diseases

(2013) Julien Ablain et al.   TRENDS IN CELL BIOLOGY

Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles

(2012) Changyang Gong et al.   BIOMATERIALS

Toxicological effect of MPA–CdSe QDs exposure on zebrafish embryo and larvae

(2012) Wei Zhang et al.   CHEMOSPHERE

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

Exploring the efficiency of gallic acid-based dendrimers and their block copolymers with PEG as gene carriers

(2012) María de la Fuente et al.   Nanomedicine

Automated Phenotype Recognition for Zebrafish Embryo Based In Vivo High Throughput Toxicity Screening of Engineered Nano-Materials

(2012) Rong Liu et al.   PLoS One

Zebrafish: An In Vivo Model for Nano EHS Studies

(2012) Sijie Lin et al.   Small

Hydration forces as a tool for the optimization of core–shell nanoparticle vectors for cancer gene therapy

(2012) M. J. Santander-Ortega et al.   Soft Matter

Zebrafish: A See-Through Host and a Fluorescent Toolbox to Probe Host–Pathogen Interaction

(2012) David M. Tobin et al.   PLoS Pathogens

High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles

(2011) Sijie Lin et al.   ACS Nano

Lessons from morpholino-based screening in zebrafish

(2011) V. M. Bedell et al.   Briefings in Functional Genomics

Xenografts in zebrafish embryos as a rapid functional assay for breast cancer stem-like cell identification

(2011) Arrate Eguiara et al.   CELL CYCLE

Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO2 nanoparticles

(2011) Jiangxin Wang et al.   CHEMOSPHERE

Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation

(2011) Fengling Li et al.   CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY

Persistent adult zebrafish behavioral deficits results from acute embryonic exposure to gold nanoparticles

(2011) Lisa Truong et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish

(2011) Ofek Bar-Ilan et al.   Nanotoxicology

Impact of dietary gold nanoparticles in zebrafish at very low contamination pressure: The role of size, concentration and exposure time

(2011) Benjamin Geffroy et al.   Nanotoxicology

Assessment of uptake and toxicity of fluorescent silica nanoparticles in zebrafish (Danio rerio) early life stages

(2010) Karl Fent et al.   AQUATIC TOXICOLOGY

The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts

(2010) Daniel S. Wagner et al.   BIOMATERIALS

Live imaging of apoptotic cells in zebrafish

(2010) Tjakko J. van Ham et al.   FASEB JOURNAL

Core−Shell Dendriplexes with Sterically Induced Stoichiometry for Gene Delivery

(2010) Manuela Raviña et al.   MACROMOLECULES

Hypoxia-induced metastasis model in embryonic zebrafish

(2010) Pegah Rouhi et al.   Nature Protocols

Zebrafish Tumor Assays: The State of Transplantation

(2010) Alison M. Taylor et al.   Zebrafish

Incorporating Zebrafish Omics into Chemical Biology and Toxicology

(2010) Hendrian Sukardi et al.   Zebrafish

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

Vincristine sulfate liposomes injection (Marqibo) in heavily pretreated patients with refractory aggressive non-Hodgkin lymphoma

(2009) M. A. Rodriguez et al.   CANCER

Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening

(2009) Steven O. Simmons et al.   TOXICOLOGICAL SCIENCES

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Toxicogenomics to Improve Comprehension of the Mechanisms Underlying Responses of In Vitro and In Vivo Systems to Nanomaterials: A Review

(2008) Anna Poma et al.   CURRENT GENOMICS

Nanoparticles as protein and gene carriers to mucosal surfaces

(2008) Maria de la Fuente et al.   Nanomedicine

Design of novel polysaccharidic nanostructures for gene delivery

(2008) M de la Fuente et al.   NANOTECHNOLOGY

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS