Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos

Colorimetric assessment of BCR-ABL1 transcripts in clinical samples via gold nanoprobes

(2016) Raquel Vinhas et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Photoactivated inhibition of cathepsin K in a 3D tumor model

(2016) Mackenzie K. Herroon et al.   BIOLOGICAL CHEMISTRY

Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands

(2016) Stefan Richter et al.   DALTON TRANSACTIONS

Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis

(2016) Legna Colina-Vegas et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Chemical Two-Photon Fluorescence

(2015) Guillermo Carrone et al.   ANALYTICAL CHEMISTRY

Acute and sub-chronic toxicity of four cytostatic drugs in zebrafish

(2015) Róbert Kovács et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Effects of the ruthenium-based drug NAMI-A on the roles played by TGF-β1 in the metastatic process

(2015) L. Brescacin et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cis-[RuCl(BzCN)(N–N)(P–P)]PF6 complexes: Synthesis and in vitro antitumor activity

(2015) Flávia de C. Pereira et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Caged oligonucleotides for studying biological systems

(2015) Brittani K. Ruble et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Platinum-Induced Neurotoxicity and Preventive Strategies: Past, Present, and Future

(2015) A. Avan et al.   ONCOLOGIST

Ruthenium-caged antisense morpholinos for regulating gene expression in zebrafish embryos

(2015) Julianne C. Griepenburg et al.   Chemical Science

Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound

(2015) Suelem D. Ramalho et al.   PLoS One

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

(2014) Ugur Akar et al.   Autophagy

Mitochondrial Fragmentation Is an Important Cellular Event Induced by Ruthenium(II) Polypyridyl Complexes in Osteosarcoma Cells

(2014) Yanxin Du et al.   ChemMedChem

Ruthenium(II) polypyridyl complexes: Cellular uptake, cell image and apoptosis of HeLa cancer cells induced by double targets

(2014) Qianqian Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the antiproliferative potential and biological targets of a trans ketoimine platinum complex

(2014) Joana Silva et al.   INORGANICA CHIMICA ACTA

Autophagic Cell Death and Cancer

(2014) Shigeomi Shimizu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies

(2014) Daniel V. Luís et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes

(2014) Leonor Côrte-Real et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization

(2014) Olga Mazuryk et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Fluorescent Ligands and Energy Transfer in Photoactive Ruthenium–Bipyridine Complexes

(2014) Guillermo Carrone et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes

(2014) Bruno Peña et al.   ORGANOMETALLICS

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

Two-Photon Optical Interrogation of Individual Dendritic Spines with Caged Dopamine

(2013) Roberto Araya et al.   ACS Chemical Neuroscience

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

Bis- and tris(2,3-dihydro-4a,12b-(epoxyethanooxy)[1,4]dioxino[2,3-f][1,10]phenanthroline) complexes of Ru(II): Synthesis, structure and DNA binding properties

(2013) Farid Hajareh Haghighi et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, characterization, DNA interaction, antioxidant and anticancer activity studies of ruthenium(II) polypyridyl complexes

(2013) Guang-Bin Jiang et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

(2012) Martin R. Gill et al.   CHEMICAL SOCIETY REVIEWS

Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage

(2012) Telma F. S. Silva et al.   DALTON TRANSACTIONS

Ruthenium polypyridyl squalene derivative: A novel self-assembling lipophilic probe for cellular imaging

(2012) Franco Dosio et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale

(2012) Penelope R. Brock et al.   JOURNAL OF CLINICAL ONCOLOGY

[RuII(η5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin

(2012) Ana Isabel Tomaz et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Developmental toxicity screening in zebrafish

(2011) Catherine W. McCollum et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Zebrafish embryos and larvae: A new generation of disease models and drug screens

(2011) Shaukat Ali et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Deactivation Pathways for Metal-to-Ligand Charge-Transfer Excited States of Ruthenium Polypyridyl Complexes with Triphenylphosphine as a Ligand

(2011) Sergey V. Litke et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing

(2011) Shaukat Ali et al.   PLoS One

Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds

(2011) Ingrid W.T. Selderslaghs et al.   REPRODUCTIVE TOXICOLOGY

Development of a zebrafish embryo teratogenicity assay and quantitative prediction model

(2010) Kimberly C. Brannen et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Structure–activity relationship assessment of four perfluorinated chemicals using a prolonged zebrafish early life stage test

(2010) A. Hagenaars et al.   CHEMOSPHERE

Cytotoxicity, apoptosis and study of the DNA-binding properties of bi- and tetranuclear gallium(III) complexes with heterocyclic thiolato ligands

(2010) Beatriz Gallego et al.   INVESTIGATIONAL NEW DRUGS

A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP

(2009) Xiangjun Meng et al.   CANCER RESEARCH

New trends for metal complexes with anticancer activity

(2008) Pieter CA Bruijnincx et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel ruthenium(ii) complexes containing the N-phosphorylated iminophosphorane-phosphine ligand Ph2PCH2P{NP(O)(OEt)2}Ph2: a new coordination mode of its methanide anion

(2008) Victorio Cadierno et al.   DALTON TRANSACTIONS

Zebrafish: a predictive model for assessing drug-induced toxicity

(2008) Patricia McGrath et al.   DRUG DISCOVERY TODAY

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS