Zebrafish xenograft models of cancer and metastasis for drug discovery

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model

(2016) Antonio Sacco et al.   CANCER RESEARCH

Studying cancer metastasis: Existing models, challenges and future perspectives

(2016) Denise M.S. van Marion et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

(2016) Marie Mayrhofer et al.   Disease Models & Mechanisms

Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays

(2016) Kalai Mangai Muthukumarasamy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

(2016) Qin Tang et al.   Nature Communications

Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism

(2016) Chengjian Zhao et al.   Scientific Reports

Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish

(2016) Hyewon Park et al.   Scientific Reports

Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis

(2016) Monica Savio et al.   Scientific Reports

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

(2016) Claudio Raimondi et al.   Scientific Reports

Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model

(2016) Miriam de Boeck et al.   Scientific Reports

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

(2015) S. Heilmann et al.   CANCER RESEARCH

miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression

(2015) E. Zoni et al.   CANCER RESEARCH

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

(2015) Kimberley J. Evason et al.   PLoS Genetics

Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development

(2014) J. Wang et al.   CANCER RESEARCH

The zebrafish/tumor xenograft angiogenesis assay as a tool for screening anti-angiogenic miRNAs

(2014) Elena Chiavacci et al.   CYTOTECHNOLOGY

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

A Synthetic dl-Nordihydroguaiaretic acid (Nordy), Inhibits Angiogenesis, Invasion and Proliferation of Glioma Stem Cells within a Zebrafish Xenotransplantation Model

(2014) Xiaojun Yang et al.   PLoS One

Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors

(2014) Beibei Zhang et al.   TUMOR BIOLOGY

Endothelial cell-initiated extravasation of cancer cells visualized in zebrafish

(2014) Masamitsu Kanada et al.   PeerJ

Evaluating human cancer cell metastasis in zebrafish

(2013) Yong Teng et al.   BMC CANCER

Zebrafish as a model for the study of neutrophil biology

(2013) Katherine M. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Vascular Development in the Zebrafish

(2013) A. V. Gore et al.   Cold Spring Harbor Perspectives in Medicine

Perspectives on cancer stem cells in osteosarcoma

(2012) Upal Basu-Roy et al.   CANCER LETTERS

Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization

(2012) Virginia Tirino et al.   FASEB JOURNAL

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

Distinct contributions of angiogenesis and vascular co-option during the initiation of primary microtumors and micrometastases

(2011) Chengjian Zhao et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Xenografts in zebrafish embryos as a rapid functional assay for breast cancer stem-like cell identification

(2011) Arrate Eguiara et al.   CELL CYCLE

SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth In Vivo

(2011) S. Zhang et al.   CLINICAL CANCER RESEARCH

Rapid BAC selection for tol2-mediated transgenesis in zebrafish

(2011) J. Bussmann et al.   DEVELOPMENT

Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment

(2011) Sangeet Lal et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Transposon-mediated BAC transgenesis in zebrafish

(2011) Maximiliano L Suster et al.   Nature Protocols

Visualizing extravasation dynamics of metastatic tumor cells

(2010) K. Stoletov et al.   JOURNAL OF CELL SCIENCE

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Fish immunology

(2009) Graham J. Lieschke et al.   CURRENT BIOLOGY

Selective plane illumination microscopy techniques in developmental biology

(2009) J. Huisken et al.   DEVELOPMENT

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

(2009) S. L. C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase C 1 Is Required for Metastasis Development and Progression

(2008) G. Sala et al.   CANCER RESEARCH

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Catch of the day: zebrafish as a human cancer model

(2008) K Stoletov et al.   ONCOGENE

Modeling Cardiovascular Disease in the Zebrafish

(2008) Timothy J.A. Chico et al.   TRENDS IN CARDIOVASCULAR MEDICINE