Vectors and strategies for nonviral cancer gene therapy

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(2018)   JOURNAL OF GENE MEDICINE

Complexation of Bioreducible Cationic Polymers with Gold Nanoparticles for Improving Stability in Serum and Application on Nonviral Gene Delivery

(2015) Chun-Chiao Chuang et al.   ACS Applied Materials & Interfaces

Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma

(2015) M Bosnjak et al.   GENE THERAPY

RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models

(2015) N. K. Tangudu et al.   MOLECULAR CANCER THERAPEUTICS

Transferrin-bearing dendrimers for cancer therapy: an update

(2015) Sukrut Somani et al.   Nanomedicine

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

(2015) Branden S Moriarity et al.   NATURE GENETICS

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

(2015) Haruna Takeda et al.   NATURE GENETICS

Efficient production of superior dumbbell-shaped DNA minimal vectors for small hairpin RNA expression

(2015) Han Yu et al.   NUCLEIC ACIDS RESEARCH

STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Invasion in Ovarian Cancer Cells

(2015) Yanhui Ma et al.   PLoS One

A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species

(2014) John R. Martin et al.   BIOMATERIALS

Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells

(2014) Daniel R Premkumar et al.   CANCER BIOLOGY & THERAPY

Integrase-Deficient Lentivirus: Opportunities and Challenges for Human Gene Therapy

(2014) Kuan-Can Liu et al.   CURRENT GENE THERAPY

miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents

(2014) Volker Baumann et al.   Future Medicinal Chemistry

Poly(2-ethyl-2-oxazoline)–PLA-g–PEI amphiphilic triblock micelles for co-delivery of minicircle DNA and chemotherapeutics

(2014) Vítor M. Gaspar et al.   JOURNAL OF CONTROLLED RELEASE

Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector

(2014) Dennis Kobelt et al.   Molecular Oncology

Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis

(2014) Irina Vyazunova et al.   PLoS One

Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers

(2014) Lian Jin et al.   Theranostics

EGFR Antisense Oligonucleotides Encapsulated with Nanoparticles Decrease EGFR, MAPK1 and STAT5 Expression in a Human Colon Cancer Cell Line

(2013) Ahmad Gholamhoseinian Najar et al.   Asian Pacific Journal of Cancer Prevention

A Smart DNA Tetrahedron That Isothermally Assembles or Dissociates in Response to the Solution pH Value Changes

(2013) Zhiyu Liu et al.   BIOMACROMOLECULES

The targeted co-delivery of DNA and doxorubicin to tumor cells via multifunctional PEI-PEG based nanoparticles

(2013) Chunxi Liu et al.   BIOMATERIALS

MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2)

(2013) Xuyang Jiao et al.   BREAST CANCER RESEARCH AND TREATMENT

Carbon nanotubes in cancer therapy: a more precise look at the role of carbon nanotube–polymer interactions

(2013) Mohsen Adeli et al.   CHEMICAL SOCIETY REVIEWS

Magnetic nanoparticles: a novel platform for cancer theranostics

(2013) Abhalaxmi Singh et al.   DRUG DISCOVERY TODAY

Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer

(2013) Reju Thomas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene delivery into human cancer cells by cationic lipid-mediated magnetofection

(2013) Srinath Govindarajan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

(2013) Jonathan E. Rosenberg et al.   INVESTIGATIONAL NEW DRUGS

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

A Mini-intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector In Vivo and In Vitro

(2013) Jiamiao Lu et al.   MOLECULAR THERAPY

Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors

(2013) Neil Senzer et al.   MOLECULAR THERAPY

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

Functionalized Graphene Oxide Mediated Adriamycin Delivery and miR-21 Gene Silencing to Overcome Tumor Multidrug Resistance In Vitro

(2013) Feng Zhi et al.   PLoS One

Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53

(2013) Ruey-Shyang Soong et al.   PLoS One

TALE: A tale of genome editing

(2013) Mingjie Zhang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Challenges and advances towards the rational design of mRNA vaccines

(2013) Charlotte Pollard et al.   TRENDS IN MOLECULAR MEDICINE

miR-221/222: promising biomarkers for breast cancer

(2013) Wei-Xian Chen et al.   TUMOR BIOLOGY

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Radio-opaque theranostic nanoemulsions with synergistic anti-cancer activity of paclitaxel and Bcl-2 siRNA

(2013) Mi Hwa Oh et al.   RSC Advances

Bombarding Cancer: Biolistic Delivery of therapeutics using Porous Si Carriers

(2013) Neta Zilony et al.   Scientific Reports

Magnetofection: A Reproducible Method for Gene Delivery to Melanoma Cells

(2013) Lara Prosen et al.   Biomed Research International

Genetic modification of dividing cells using episomally maintained S/MAR DNA vectors

(2013) Suet-Ping Wong et al.   Molecular Therapy-Nucleic Acids

Trial watch

(2013) Laura Senovilla et al.   OncoImmunology

A review of nanocarriers for the delivery of small interfering RNA

(2012) Prashant Kesharwani et al.   BIOMATERIALS

Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

(2012) Ahmed A. Eltoukhy et al.   BIOMATERIALS

Prevention of tumor growth by needle-free jet injection of anti-C7orf24 siRNA

(2012) S Hama et al.   CANCER GENE THERAPY

Ultrasound-Targeted Microbubble Destruction to Deliver siRNA Cancer Therapy

(2012) A. R. Carson et al.   CANCER RESEARCH

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

(2012) T. Gutschner et al.   CANCER RESEARCH

Selective Gene Delivery to Cancer Cells Using an Integrated Cationic Amphiphilic Peptide

(2012) Qiong Tang et al.   LANGMUIR

Treating colon cancer with a suicide gene delivered by self-assembled cationic MPEG–PCL micelles

(2012) XingMei Duan et al.   Nanoscale

Phase I Clinical Trial of Systemically Administered TUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans

(2012) Charles Lu et al.   PLoS One

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

Quantification of AAV Particle Titers by Infrared Fluorescence Scanning of Coomassie-Stained Sodium Dodecyl Sulfate–Polyacrylamide Gels

(2012) Erik Kohlbrenner et al.   Human Gene Therapy Methods

TFPI  is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes

(2011) T. J. Girard et al.   BLOOD

A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB

(2011) Inès Souissi et al.   BMC CELL BIOLOGY

Sonoporation-mediated anti-angiogenic gene transfer into muscle effectively regresses distant orthotopic tumors

(2011) Z-K Liao et al.   CANCER GENE THERAPY

Genetically Modified T cells Targeting Interleukin-11 Receptor  -Chain Kill Human Osteosarcoma Cells and Induce the Regression of Established Osteosarcoma Lung Metastases

(2011) G. Huang et al.   CANCER RESEARCH

Plasmid DNA Gene Therapy by Electroporation: Principles and Recent Advances

(2011) Tatsufumi Murakami et al.   CURRENT GENE THERAPY

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

Non-viral episomal modification of cells using S/MAR elements

(2011) Orestis Argyros et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors

(2011) W Walther et al.   GENE THERAPY

Nonviral Gene Delivery with the Sleeping Beauty Transposon System

(2011) Zoltán Ivics et al.   HUMAN GENE THERAPY

Infusing CD19-Directed T Cells to Augment Disease Control in Patients Undergoing Autologous Hematopoietic Stem-Cell Transplantation for Advanced B-Lymphoid Malignancies

(2011) Partow Kebriaei et al.   HUMAN GENE THERAPY

Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors

(2011) Dirk Strumberg et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Bioimpacts of Anti Epidermal Growth Receptor Antisense Complexed with Polyamidoamine Dendrimers in Human Lung Epithelial Adenocarcinoma Cells

(2011) Ailar Nakhlband et al.   Journal of Biomedical Nanotechnology

Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion

(2011) Ashlyn J Bernier et al.   Molecular Cancer

Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer

(2011) Xiaoxuan Liu et al.   MOLECULAR PHARMACEUTICS

PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor

(2011) Yozo Nakazawa et al.   MOLECULAR THERAPY

Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

(2011) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

Combining mTor Inhibitors With Rapamycin-resistant T Cells: A Two-pronged Approach to Tumor Elimination

(2011) Leslie E Huye et al.   MOLECULAR THERAPY

Adjuvant Trastuzumab in HER2-Positive Breast Cancer

(2011) Dennis Slamon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Minicircle-oriP-IFNγ: A Novel Targeted Gene Therapeutic System for EBV Positive Human Nasopharyngeal Carcinoma

(2011) Yufang Zuo et al.   PLoS One

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Gene Expression Analysis Identifies Potential Biomarkers of Neurofibromatosis Type 1 Including Adrenomedullin

(2010) T. R. Hummel et al.   CLINICAL CANCER RESEARCH

DNA Transposons: Nature and Applications in Genomics

(2010) Martin Munoz-Lopez et al.   CURRENT GENOMICS

DNA Vaccines: Developing New Strategies against Cancer

(2010) Daniela Fioretti et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Transcriptional regulation of inducible nitric oxide synthase gene therapy: targeting early stage and advanced prostate cancer

(2010) Jonathan A. Coulter et al.   JOURNAL OF GENE MEDICINE

A Transposon and Transposase System for Human Application

(2010) Perry B Hackett et al.   MOLECULAR THERAPY

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Nonviral Gene Delivery: Principle, Limitations, and Recent Progress

(2009) Mohammed S. Al-Dosari et al.   AAPS Journal

Treatment of malignant gliomas with TGF-β2 antisense oligonucleotides

(2009) Peter Hau et al.   Expert Review of Anticancer Therapy

Progress and Prospects: The design and production of plasmid vectors

(2009) D R Gill et al.   GENE THERAPY

Five-Year Outcome of Lung Cancer Detection in Patients With and Without Airflow Obstruction in a Primary Care Outpatient Practice

(2009) Joel J. Bechtel et al.   Journal of Thoracic Oncology

An Ion Channel Hypothesis to Explain Divergent Cardiovascular Safety of Cyclooxygenase-2 Inhibitors: The Answer to a Hotly Debated Puzzle?

(2009) M. S. Shapiro   MOLECULAR PHARMACOLOGY

Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy

(2009) Chunxiao Wu et al.   MOLECULAR THERAPY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Silencing by nuclear matrix attachment distinguishes cell-type specificity: association with increased proliferation capacity

(2009) Amelia K. Linnemann et al.   NUCLEIC ACIDS RESEARCH

Long-Term Suppression of Hepatitis B Virus Replication by Short Hairpin RNA Expression Using the Scaffold/Matrix Attachment Region-Based Replicating Vector System pEPI-1

(2008) A. C. W. Jenke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Redirecting Specificity of T-Cell Populations For CD19 Using the Sleeping Beauty System

(2008) H. Singh et al.   CANCER RESEARCH

Phase I/II Study of G3139 (Bcl-2 Antisense Oligonucleotide) in Combination with Doxorubicin and Docetaxel in Breast Cancer

(2008) S. L. Moulder et al.   CLINICAL CANCER RESEARCH

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia

(2008) Joachim Köchling et al.   VACCINE