Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish

Hypoxia-recruited angiogenic neutrophils

(2015) E. L. Campbell   BLOOD

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish

(2015) Chuan Yan et al.   JOURNAL OF HEPATOLOGY

Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation

(2015) Lili Sun et al.   PLoS One

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via  2 integrins (CD11/CD18)

(2014) L. T. Weckbach et al.   BLOOD

The zebrafish/tumor xenograft angiogenesis assay as a tool for screening anti-angiogenic miRNAs

(2014) Elena Chiavacci et al.   CYTOTECHNOLOGY

Transcriptional divergence of the duplicated hypoxia-inducible factor alpha genes in zebrafish

(2014) Kalle T. Rytkönen et al.   GENE

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

(2014) Meixiao Shen et al.   PLoS One

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3

(2013) Panu M. Jaakkola et al.   BIOLOGICAL CHEMISTRY

Evaluating human cancer cell metastasis in zebrafish

(2013) Yong Teng et al.   BMC CANCER

Neutrophil-mediated tumour angiogenesis: Subversion of immune responses to promote tumour growth

(2013) Simon Tazzyman et al.   SEMINARS IN CANCER BIOLOGY

A Zebrafish Model to Study and Therapeutically Manipulate Hypoxia Signaling in Tumorigenesis

(2012) Kirankumar Santhakumar et al.   CANCER RESEARCH

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

(2012) Z. Li et al.   Disease Models & Mechanisms

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape

(2012) Salem Chouaib et al.   Frontiers in Immunology

Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway

(2011) Jimmy R. Theriault et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

(2011) M. R. Doe et al.   CANCER RESEARCH

Liver tumor models in transgenic zebrafish: an alternativein vivoapproach to study hepatocarcinogenes

(2011) Xiaoqian Huang et al.   Future Oncology

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

(2011) Bharath Nath et al.   HEPATOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Neuropilins and semaphorins — from angiogenesis to autoimmunity

(2010) Z. Vadasz et al.   AUTOIMMUNITY REVIEWS

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

(2010) Hui Feng et al.   CANCER CELL

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

(2010) S. Rey et al.   CARDIOVASCULAR RESEARCH

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

(2010) Cormac T. Taylor et al.   PHYSIOLOGY

LIMK1 and LIMK2 Are Important for Metastatic Behavior and Tumor Cell-Induced Angiogenesis of Pancreatic Cancer Cells

(2010) Danielle H. Vlecken et al.   Zebrafish

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions

(2009) Elena I. Deryugina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration

(2009) C. Liongue et al.   BLOOD

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

(2009) Chen-Xin Dai et al.   BMC CANCER

Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies

(2009) Annamaria Rapisarda et al.   DRUG RESISTANCE UPDATES

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

(2009) S. L. C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of adaptive angiogenesis to tissue hypoxia

(2008) Guo-Hua Fong   ANGIOGENESIS

Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish

(2008) Svetlana Korzh et al.   BMC DEVELOPMENTAL BIOLOGY

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition

(2008) D. T. Dang et al.   CANCER RESEARCH

Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation

(2008) L E Huang   CELL DEATH AND DIFFERENTIATION

Pathways Mediating Resistance to Vascular Endothelial Growth Factor-Targeted Therapy

(2008) L. M. Ellis et al.   CLINICAL CANCER RESEARCH

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies

(2008) Farbod Shojaei et al.   DRUG RESISTANCE UPDATES

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis

(2008) Shelly Beer et al.   PLoS One

PHDs overactivation during chronic hypoxia "desensitizes" HIF  and protects cells from necrosis

(2008) A. Ginouves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA