Hooked! Modeling human disease in zebrafish

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome

(2011) Danai Bem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy

(2011) Nadine Norton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Zebrafish Models for Cancer

(2011) Shu Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Zebrafish kidney development: Basic science to translational research

(2011) Lisa M. Swanhart et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

The genetics of ocular disorders: Insights from the zebrafish

(2011) Ann C. Morris   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

(2011) Kelly A Avery-Kiejda et al.   BMC CANCER

The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

(2011) Fabian Chablais et al.   BMC DEVELOPMENTAL BIOLOGY

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

(2011) Wolfram Goessling et al.   Cell Stem Cell

Modeling Neurodegeneration in Zebrafish

(2011) Yanwei Xi et al.   Current Neurology and Neuroscience Reports

Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish

(2011) C. Zhu et al.   DEVELOPMENT

The Conserved Clusterin Gene Is Expressed in the Developing Choroid Plexus Under the Regulation of Notch But Not IGF Signaling in Zebrafish

(2011) Shuang Jiao et al.   ENDOCRINOLOGY

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation

(2011) Alison M. Taylor et al.   EXPERIMENTAL HEMATOLOGY

A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy

(2011) Marian A.J. Weterman et al.   HUMAN MOLECULAR GENETICS

Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

(2011) Cuong Q. Diep et al.   NATURE

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

New gene functions in megakaryopoiesis and platelet formation

(2011) Christian Gieger et al.   NATURE

De novo cardiomyocytes from within the activated adult heart after injury

(2011) Nicola Smart et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

(2011) Ting Li et al.   NUCLEIC ACIDS RESEARCH

Shared acquired genomic changes in zebrafish and human T-ALL

(2011) L A Rudner et al.   ONCOGENE

Somatic Mutagenesis with a Sleeping Beauty Transposon System Leads to Solid Tumor Formation in Zebrafish

(2011) Maura McGrail et al.   PLoS One

A New System for the Rapid Collection of Large Numbers of Developmentally Staged Zebrafish Embryos

(2011) Isaac Adatto et al.   PLoS One

Drug screening in a zebrafish model of Duchenne muscular dystrophy

(2011) G. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish behavioural assays of translational relevance for the study of psychiatric disease

(2011) Caroline H. Brennan   REVIEWS IN THE NEUROSCIENCES

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Modeling Diamond Blackfan Anemia in the Zebrafish

(2011) Alison M. Taylor et al.   SEMINARS IN HEMATOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Zebrafish as a tool in Alzheimer's disease research

(2010) Morgan Newman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

zTrap: zebrafish gene trap and enhancer trap database

(2010) Koichi Kawakami et al.   BMC DEVELOPMENTAL BIOLOGY

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

(2010) Hui Feng et al.   CANCER CELL

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

(2010) David S. Peal et al.   CIRCULATION

Cardiac arrhythmia:in vivoscreening in the zebrafish to overcome complexity in drug discovery

(2010) Calum A MacRae   Expert Opinion on Drug Discovery

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy

(2010) John F. O’Toole et al.   JOURNAL OF CLINICAL INVESTIGATION

Intraflagellar Transport Proteins Are Essential for Cilia Formation and for Planar Cell Polarity

(2010) Y. Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells

(2010) Diarmuid M. Moran et al.   MOLECULAR CANCER THERAPEUTICS

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

(2010) David Kokel et al.   Nature Chemical Biology

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases

(2010) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

Kita Driven Expression of Oncogenic HRAS Leads to Early Onset and Highly Penetrant Melanoma in Zebrafish

(2010) Cristina Santoriello et al.   PLoS One

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

(2010) J. Rihel et al.   SCIENCE

Zebrafish Tumor Assays: The State of Transplantation

(2010) Alison M. Taylor et al.   Zebrafish

Thymosin β4 induces epicardium-derived neovascularization in the adult heart: Figure 1

(2009) Paul R. Riley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

(2009) E. van Rooijen et al.   BLOOD

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

(2009) David J. Milan et al.   CIRCULATION

The primary cilium as a cellular signaling center: lessons from disease

(2009) Madeline A Lancaster et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Reprogramming of melanoma cells by embryonic microenvironments

(2009) Alejandro Diez-torre et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The most transparent research

(2009) Melinda Wenner   NATURE MEDICINE

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

(2008) N. Danilova et al.   BLOOD

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye

(2008) Jiwoon Lee et al.   DEVELOPMENTAL BIOLOGY

Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish

(2008) Alexander Emelyanov et al.   DEVELOPMENTAL BIOLOGY

montalcino, A zebrafish model for variegate porphyria

(2008) Kimberly A. Dooley et al.   EXPERIMENTAL HEMATOLOGY

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia

(2008) Tamayo Uechi et al.   HUMAN MOLECULAR GENETICS

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease

(2008) M. Moosajee et al.   HUMAN MOLECULAR GENETICS

LRRC50, a Conserved Ciliary Protein Implicated in Polycystic Kidney Disease

(2008) E. van Rooijen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

(2008) Xiangdong Meng et al.   NATURE BIOTECHNOLOGY

Restoration of renal function in zebrafish models of ciliopathies

(2008) Jonathan L. Tobin et al.   PEDIATRIC NEPHROLOGY