From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics

Microenvironment-derived factors driving metastatic plasticity in melanoma

(2017) Isabella S. Kim et al.   Nature Communications

Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish

(2016) Chen-Hui Chen et al.   DEVELOPMENTAL CELL

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies

(2016) Michelle Dang et al.   Disease Models & Mechanisms

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc -null SCID zebrafish

(2016) John C. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes

(2016) Christopher T. Dee et al.   JOURNAL OF IMMUNOLOGY

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis

(2016) Anna C. Thomas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

(2016) Justin L. Tan et al.   MOLECULAR CELL

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development

(2016) Jonathan Henninger et al.   NATURE CELL BIOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole-organism lineage tracing by combinatorial and cumulative genome editing

(2016) Aaron McKenna et al.   SCIENCE

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

(2016) Qin Tang et al.   Nature Communications

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

(2015) S. Heilmann et al.   CANCER RESEARCH

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The melanocyte lineage in development and disease

(2015) R. L. Mort et al.   DEVELOPMENT

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

Zebrafish as a model to assess cancer heterogeneity, progression and relapse

(2014) J. S. Blackburn et al.   Disease Models & Mechanisms

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

Temperature-sensitive splicing ofmitfaby an intron mutation in zebrafish

(2014) Zhiqiang Zeng et al.   Pigment Cell & Melanoma Research

Clonal Architectures and Driver Mutations in Metastatic Melanomas

(2014) Li Ding et al.   PLoS One

The melanoma revolution: From UV carcinogenesis to a new era in therapeutics

(2014) J. A. Lo et al.   SCIENCE

Origins of Metastatic Traits

(2013) Sakari Vanharanta et al.   CANCER CELL

A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species

(2013) Cong Xu et al.   CELL

Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish

(2013) Y. Albert Pan et al.   DEVELOPMENT

Constitutive Rac Activation Is Not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression

(2013) Lucy E. Dalton et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

(2013) James A. Lister et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Melanoma metastasis: new concepts and evolving paradigms

(2013) W E Damsky et al.   ONCOGENE

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

(2013) Jennifer Yen et al.   GENOME BIOLOGY

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

(2012) Linna Zhou et al.   CHEMISTRY & BIOLOGY

lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish

(2012) K. S. Okuda et al.   DEVELOPMENT

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

(2012) Devarati Mitra et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

Systematic classification of melanoma cells by phenotype-specific gene expression mapping

(2012) Daniel S. Widmer et al.   Pigment Cell & Melanoma Research

Evidence of Melanoma in Wild Marine Fish Populations

(2012) Michael Sweet et al.   PLoS One

High-Throughput Screening for Bioactive Molecules Using Primary Cell Culture of Transgenic Zebrafish Embryos

(2012) Haigen Huang et al.   Cell Reports

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf

(2011) Kerrie L. Taylor et al.   DEVELOPMENT

Genome-wide association study identifies novel loci predisposing to cutaneous melanoma†

(2011) Christopher I. Amos et al.   HUMAN MOLECULAR GENETICS

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Genome-wide association study identifies three new melanoma susceptibility loci

(2011) Jennifer H Barrett et al.   NATURE GENETICS

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

(2011) Stuart MacGregor et al.   NATURE GENETICS

A New System for the Rapid Collection of Large Numbers of Developmentally Staged Zebrafish Embryos

(2011) Isaac Adatto et al.   PLoS One

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Kita Driven Expression of Oncogenic HRAS Leads to Early Onset and Highly Penetrant Melanoma in Zebrafish

(2010) Cristina Santoriello et al.   PLoS One

Global Repression of Cancer Gene Expression in a Zebrafish Model of Melanoma Is Linked to Epigenetic Regulation

(2010) Viviana Anelli et al.   Zebrafish

Zebrafish Have a Competent p53-Dependent Nucleotide Excision Repair Pathway to Resolve Ultraviolet B–Induced DNA Damage in the Skin

(2010) Zhiqiang Zeng et al.   Zebrafish

Intraperitoneal Injection into Adult Zebrafish

(2010) Mary D. Kinkel et al.   Jove-Journal of Visualized Experiments

Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model

(2009) C. Michailidou et al.   Disease Models & Mechanisms

Genetic risk factors for melanoma

(2009) Kathrine Damm Meyle et al.   HUMAN GENETICS

Genome-wide association study identifies three loci associated with melanoma risk

(2009) D Timothy Bishop et al.   NATURE GENETICS

Melanoma Biology and the Promise of Zebrafish

(2009) Craig J. Ceol et al.   Zebrafish

mc1r Pathway Regulation of Zebrafish Melanosome Dispersion

(2009) Jennifer Richardson et al.   Zebrafish

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

(2009) Michael Dovey et al.   Zebrafish

Retro-orbital Injection in Adult Zebrafish

(2009) Emily K. Pugach et al.   Jove-Journal of Visualized Experiments

Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?

(2008) Ling Hou et al.   CELL RESEARCH

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Phase III Trial Comparing Concurrent Biochemotherapy With Cisplatin, Vinblastine, Dacarbazine, Interleukin-2, and Interferon Alfa-2b With Cisplatin, Vinblastine, and Dacarbazine Alone in Patients With Metastatic Malignant Melanoma (E3695): A Trial Coordinated by the Eastern Cooperative Oncology Group

(2008) Michael B. Atkins et al.   JOURNAL OF CLINICAL ONCOLOGY

Common sequence variants on 20q11.22 confer melanoma susceptibility

(2008) Kevin M Brown et al.   NATURE GENETICS