Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

Changes in tumor cell heterogeneity after chemotherapy treatment in a xenograft model of glioblastoma

(2017) Alessandra M. Welker et al.   NEUROSCIENCE

From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics

(2017) Ellen van Rooijen et al.   Pigment Cell & Melanoma Research

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

(2017) T Terwilliger et al.   Blood Cancer Journal

Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines

(2017) Barbara Breznik et al.   Oncotarget

Stem cell cultures derived from pediatric brain tumors accurately model the originating tumors

(2017) Anna Wenger et al.   Oncotarget

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

(2017) Viviana Anelli et al.   eLife

Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer

(2016) Tianzhi Yang et al.   AAPS Journal

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Problems of glioblastoma multiforme drug resistance

(2016) A. A. Stavrovskaya et al.   BIOCHEMISTRY-MOSCOW

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Correction: Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity

(2016) Alessandra M. Welker et al.   Disease Models & Mechanisms

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

(2016) Marie Mayrhofer et al.   Disease Models & Mechanisms

CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling

(2016) Jiaqi Liu et al.   HUMAN GENETICS

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc -null SCID zebrafish

(2016) John C. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes

(2016) Christopher T. Dee et al.   JOURNAL OF IMMUNOLOGY

Moving the needle: Optimizing classification for glioma

(2016) Roel G. W. Verhaak   Science Translational Medicine

A Zebrafish Live Imaging Model Reveals Differential Responses of Microglia Toward Glioblastoma Cells In Vivo

(2016) Lloyd Hamilton et al.   Zebrafish

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics

(2016) Laura Fernandez del Ama et al.   Oncotarget

MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells

(2016) Katarzyna Modzelewska et al.   Cell Reports

The role of DNA damage responses in p53 biology

(2015) Daniel Speidel   ARCHIVES OF TOXICOLOGY

How I treat T-cell acute lymphoblastic leukemia in adults

(2015) M. R. Litzow et al.   BLOOD

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

(2015) S. Heilmann et al.   CANCER RESEARCH

A fresh look at zebrafish from the perspective of cancer research

(2015) Shuai Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oncogenic KRAS promotes malignant brain tumors in zebrafish

(2015) Bensheng Ju et al.   Molecular Cancer

Genomics in acute lymphoblastic leukaemia: insights and treatment implications

(2015) Kathryn G. Roberts et al.   Nature Reviews Clinical Oncology

Acute Lymphoblastic Leukemia in Children

(2015) Stephen P. Hunger et al.   NEW ENGLAND JOURNAL OF MEDICINE

What is a vertebrate pigment cell?

(2015) Manfred Schartl et al.   Pigment Cell & Melanoma Research

Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy

(2015) Anna Niezgoda et al.   Biomed Research International

The NOTCH signaling pathway in normal and malignant blood cell production

(2015) Sukanya Suresh et al.   Journal of Cell Communication and Signaling

Melanoma

(2015) Dirk Schadendorf et al.   Nature Reviews Disease Primers

The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

(2014) Boris C. Bastian   Annual Review of Pathology-Mechanisms of Disease

Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation

(2014) Jessica S. Blackburn et al.   CANCER CELL

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

Melanoma—the run of success continues

(2014) Dirk Schadendorf et al.   Nature Reviews Clinical Oncology

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Orthotopic models of pediatric brain tumors in zebrafish

(2014) C J Eden et al.   ONCOGENE

Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma

(2014) Xiaowei Guan et al.   PLoS One

A Synthetic dl-Nordihydroguaiaretic acid (Nordy), Inhibits Angiogenesis, Invasion and Proliferation of Glioma Stem Cells within a Zebrafish Xenotransplantation Model

(2014) Xiaojun Yang et al.   PLoS One

The Use of Molecular Genetics to Refine Prognosis in Acute Myeloid Leukemia

(2014) Bhavana Bhatnagar et al.   Current Hematologic Malignancy Reports

Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway

(2014) B Ju et al.   Oncogenesis

Zebrafish embryo as a tool to study tumor/endothelial cell cross-talk

(2013) Chiara Tobia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

(2013) C. Cutler et al.   BLOOD

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ -catenin signaling pathway

(2013) Y. Zhang et al.   BLOOD

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway

(2013) E Alghisi et al.   LEUKEMIA

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish

(2013) In Hye Jung et al.   NEURO-ONCOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity

(2013) J Viotti et al.   ONCOGENE

A Novel Zebrafish Xenotransplantation Model for Study of Glioma Stem Cell Invasion

(2013) Xiao-jun Yang et al.   PLoS One

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

(2013) Angeleen Fleming et al.   PLoS One

Wnt activation promotes neuronal differentiation of Glioblastoma

(2013) E Rampazzo et al.   Cell Death & Disease

Zebrafish screen identifies novel compound with selective toxicity against leukemia

(2012) S. Ridges et al.   BLOOD

Deregulated Signaling Pathways in Glioblastoma Multiforme: Molecular Mechanisms and Therapeutic Targets

(2012) Hua Mao et al.   CANCER INVESTIGATION

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

(2012) J. Shin et al.   Disease Models & Mechanisms

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

(2012) J S Blackburn et al.   LEUKEMIA

Small molecule screening identifies targetable zebrafish pigmentation pathways

(2012) Sarah Colanesi et al.   Pigment Cell & Melanoma Research

Zebrafish in Endocrine Systems: Recent Advances and Implications for Human Disease

(2011) Heiko Löhr et al.   Annual Review of Physiology

Gene mutation and AML pathogenesis

(2011) H. Dombret   BLOOD

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis

(2011) A. Michael Forrester et al.   BRITISH JOURNAL OF HAEMATOLOGY

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

(2011) Wolfram Goessling et al.   Cell Stem Cell

Zebrafish as a model for normal and malignant hematopoiesis

(2011) L. Jing et al.   Disease Models & Mechanisms

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

(2011) B. Pruvot et al.   HAEMATOLOGICA

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

(2011) Alejandro Gutierrez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment

(2011) Sangeet Lal et al.   JOURNAL OF NEUROSCIENCE RESEARCH

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

(2011) Stuart MacGregor et al.   NATURE GENETICS

Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor

(2011) N.-A. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

The zebrafish as a model for cancer

(2010) M. C. Mione et al.   Disease Models & Mechanisms

Hematopoietic development in the zebrafish

(2010) Elizabeth J. Paik et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kita Driven Expression of Oncogenic HRAS Leads to Early Onset and Highly Penetrant Melanoma in Zebrafish

(2010) Cristina Santoriello et al.   PLoS One

Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model

(2009) C. Michailidou et al.   Disease Models & Mechanisms

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

(2009) Michael Dovey et al.   Zebrafish

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

(2008) Julia Zhuravleva et al.   BRITISH JOURNAL OF HAEMATOLOGY

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

(2008) W. M. Lin et al.   CANCER RESEARCH

Temozolomide-Mediated Radiosensitization of Human Glioma Cells in a Zebrafish Embryonic System

(2008) G. A. Geiger et al.   CANCER RESEARCH

Conspirators in a Capital Crime: Co-deletion of p18INK4cand p16INK4a/p14ARF/p15INK4bin Glioblastoma Multiforme: Figure 1.

(2008) David A. Solomon et al.   CANCER RESEARCH

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE