The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease

(2016) M. Madan Babu   BIOCHEMICAL SOCIETY TRANSACTIONS

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

The role of the 14-3-3 protein family in health, disease, and drug development

(2016) Yasaman Aghazadeh et al.   DRUG DISCOVERY TODAY

2′-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression

(2016) Hai-Anh Nguyen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

BAG3 Protein Is Over-Expressed in Endometrioid Endometrial Adenocarcinomas

(2016) Veronica Esposito et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BAG3 regulates contractility and Ca2+ homeostasis in adult mouse ventricular myocytes

(2016) Arthur M. Feldman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis

(2016) Patrick Antonietti et al.   MOLECULAR CANCER THERAPEUTICS

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

BIS-mediated STAT3 stabilization regulates glioblastoma stem cell-like phenotypes

(2016) Chang-Nim Im et al.   Oncotarget

Familial Dilated Cardiomyopathy Caused by a Novel Frameshift in the BAG3 Gene

(2016) Rocio Toro et al.   PLoS One

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

The integration of autophagy and cellular trafficking pathways via RAB GAPs

(2015) Andreas Kern et al.   Autophagy

BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism

(2015) Andrea E. Rodríguez et al.   Autophagy

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

(2015) Anna Ulbricht et al.   Autophagy

BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress

(2015) Young-Hee Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter

(2015) J. A. Kim et al.   CARCINOGENESIS

Autophagy signal transduction by ATG proteins: from hierarchies to networks

(2015) Sebastian Wesselborg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure

(2015) Parul U. Gandhi et al.   CLINICA CHIMICA ACTA

BAG3: a new player in the heart failure paradigm

(2015) Tijana Knezevic et al.   HEART FAILURE REVIEWS

Membrane dynamics in autophagosome biogenesis

(2015) S. R. Carlsson et al.   JOURNAL OF CELL SCIENCE

BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome

(2015) Anna Kostera-Pruszczyk et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

(2015) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP

(2015) Arpita Kundu et al.   MOLECULAR NEUROBIOLOGY

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

BAG3 myofibrillar myopathy presenting with cardiomyopathy

(2015) Chamindra G. Konersman et al.   NEUROMUSCULAR DISORDERS

Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737

(2015) Jens Mani et al.   WORLD JOURNAL OF UROLOGY

BAG3 regulates formation of the SNARE complex and insulin secretion

(2015) V Iorio et al.   Cell Death & Disease

NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways

(2015) F Rapino et al.   Cell Death & Disease

Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function

(2015) V Felzen et al.   Cell Death & Disease

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages

(2015) Alessandra Rosati et al.   Nature Communications

The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth

(2015) Gennaro Chiappetta et al.   Oncotarget

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Nonsense Mutations in BAG3 are Associated With Early-Onset Dilated Cardiomyopathy in French Canadians

(2014) Nathalie Chami et al.   CANADIAN JOURNAL OF CARDIOLOGY

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

BAG3 mRNA is present in synaptosomal polysomes of rat brain

(2014) Anna Paola Bruno et al.   CELL CYCLE

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation of autophagy: Modulation of the size and number of autophagosomes

(2014) Meiyan Jin et al.   FEBS LETTERS

Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy

(2014) Arthur M. Feldman et al.   JOURNAL OF CELLULAR PHYSIOLOGY

WW Domain of BAG3 Is Required for the Induction of Autophagy in Glioma Cells

(2014) Nana Merabova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation

(2014) Maria Franaszczyk et al.   Journal of Translational Medicine

Identification of Extracellular Signal-regulated Kinase 1 (ERK1) Direct Substrates using Stable Isotope Labeled Kinase Assay-Linked Phosphoproteomics

(2014) Liang Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 Activation

(2014) Martina P. Pasillas et al.   MOLECULAR & CELLULAR PROTEOMICS

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

Unusual multisystemic involvement and a novel BAG3 mutation revealed by NGS screening in a large cohort of myofibrillar myopathies

(2014) Anna-Lena Semmler et al.   Orphanet Journal of Rare Diseases

14-3-3 and aggresome formation: Implications in neurodegenerative diseases

(2014) Baohui Jia et al.   Prion

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

BAG3 protein expression in melanoma metastatic lymph nodes correlates with patients’ survival

(2014) L Guerriero et al.   Cell Death & Disease

BAG3 Protein in Advanced-Stage Heart Failure

(2014) Margot De Marco et al.   JACC-Heart Failure

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

Therapeutic induction of autophagy to modulate neurodegenerative disease progression

(2013) Warren E Hochfeld et al.   ACTA PHARMACOLOGICA SINICA

BAG3 Is a Novel Serum Biomarker for Pancreatic Adenocarcinomas

(2013) Antonia Falco et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia

(2013) Huayuan Zhu et al.   ANNALS OF HEMATOLOGY

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy

(2013) Moran Rawet Slobodkin et al.   Essays in Biochemistry

The Natural Compound Cantharidin Induces Cancer Cell Death through Inhibition of Heat Shock Protein 70 (HSP70) and Bcl-2-associated Athanogene Domain 3 (BAG3) Expression by Blocking Heat Shock Factor 1 (HSF1) Binding to Promoters

(2013) Joo Ae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

(2013) Z. Xu et al.   JOURNAL OF CELL SCIENCE

BAG3 regulates epithelial–mesenchymal transition and angiogenesis in human hepatocellular carcinoma

(2013) Heng Xiao et al.   LABORATORY INVESTIGATION

Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity

(2013) Ying Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

BH3 Mimetics: Status of the Field and New Developments

(2013) C. Billard   MOLECULAR CANCER THERAPEUTICS

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy in Human Health and Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential autophagy power in the spinal cord and muscle of transgenic ALS mice

(2013) Valeria Crippa et al.   Frontiers in Cellular Neuroscience

Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure

(2013) M De Marco et al.   Cell Death & Disease

What Renders TAU Toxic

(2013) Jürgen Götz et al.   Frontiers in Neurology

Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival

(2012) Alessandra Rosati et al.   AMERICAN JOURNAL OF PATHOLOGY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

The family of mammalian small heat shock proteins (HSPBs): Implications in protein deposit diseases and motor neuropathies

(2012) Alessandra Boncoraglio et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NF- B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex

(2012) M. Nivon et al.   JOURNAL OF CELL SCIENCE

BAG3 mutations: another cause of giant axonal neuropathy

(2012) Fatima Jaffer et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Protein Homeostasis, Aging and Alzheimer’s Disease

(2012) Tobias Morawe et al.   MOLECULAR NEUROBIOLOGY

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy

(2012) Jaakko Sarparanta et al.   NATURE GENETICS

PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial−mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells

(2012) N Li et al.   ONCOGENE

Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy

(2011) Nadine Norton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

BAG3 and friends: Co-chaperones in selective autophagy during aging and disease

(2011) Christian Behl   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Identification of a synaptosome- associated form of BAG3 protein

(2011) Anna Paola Bruno et al.   CELL CYCLE

BAG3-related myofibrillar myopathy in a Chinese family

(2011) HC Lee et al.   CLINICAL GENETICS

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

Dilated cardiomyopathy-associatedBAG3mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

(2011) Takuro Arimura et al.   HUMAN MUTATION

BAG3 Expression in Glioblastoma Cells Promotes Accumulation of Ubiquitinated Clients in an Hsp70-dependent Manner

(2011) Antonio Gentilella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

(2011) Hui Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

(2011) Martin Gamerdinger et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes

(2011) Xingqian Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases

(2011) K. Seidel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

14-3-3 proteins as potential therapeutic targets

(2011) Jing Zhao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BAG3: a multifaceted protein that regulates major cell pathways

(2011) A Rosati et al.   Cell Death & Disease

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

(2010) Valeria Crippa et al.   Autophagy

BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion

(2010) Masahiro Iwasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of the Hsp70 chaperone systemThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Jason C. Young   Biochemistry and Cell Biology

BAG3 expression is sustained by FGF2 in neural progenitor cells and impacts cell proliferation

(2010) Antonio Gentilella et al.   CELL CYCLE

BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress

(2010) Akinori Hishiya et al.   CIRCULATION RESEARCH

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Myofibrillar myopathies

(2010) Duygu Selcen   CURRENT OPINION IN NEUROLOGY

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3

(2010) Shaoming Song et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Co-chaperone BAG3 and adenovirus penton base protein partnership

(2010) E. Gout et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

WT1 protein is a transcriptional activator of the antiapoptotic bag3 gene

(2010) E Cesaro et al.   LEUKEMIA

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation

(2010) Zagaa Odgerel et al.   NEUROMUSCULAR DISORDERS

Quantitative Phosphoproteomics of Proteasome Inhibition in Multiple Myeloma Cells

(2010) Feng Ge et al.   PLoS One

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Caught in the middle: the role of Bag3 in disease: Figure 1

(2009) Andrea K. McCollum et al.   BIOCHEMICAL JOURNAL

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

(2009) Margit Fuchs et al.   BIOCHEMICAL JOURNAL

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Autoregulation of co-chaperone BAG3 gene transcription

(2009) Antonio Gentilella et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Anti-Apoptotic Activity of BAG3 Is Restricted by Caspases and the Proteasome

(2009) Victoria M. Virador et al.   PLoS One

Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus

(2008) Dong-Ye Youn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

bag3 gene expression is regulated by heat shock factor 1

(2008) Silvia Franceschelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quantitative Analysis of global Ubiquitination in HeLa Cells by Mass Spectrometry

(2008) David Meierhofer et al.   JOURNAL OF PROTEOME RESEARCH

Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine

(2008) Jonathan P. Schuermann et al.   MOLECULAR CELL

Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells

(2008) A Gentilella et al.   ONCOGENE

The co-chaperone BAG3 regulates Herpes Simplex Virus replication

(2008) C. A. Kyratsous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional upregulation of BAG3 upon proteasome inhibition

(2007) Hua-Qin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS