Targeting protein aggregation for the treatment of degenerative diseases

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

(2015) Simona Eleuteri et al.   NEUROBIOLOGY OF DISEASE

Repurposing Diflunisal for Familial Amyloid Polyneuropathy

(2015) John L. Berk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

(2014) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

(2014) Irit Rappley et al.   BIOCHEMISTRY

One siRNA pool targeting the   constant region stops   light-chain production and causes terminal endoplasmic reticulum stress

(2014) P. Zhou et al.   BLOOD

Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

(2014) Meredith E. Jackrel et al.   CELL

Reversing deleterious protein aggregation with re-engineered protein disaggregases

(2014) Meredith E Jackrel et al.   CELL CYCLE

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms

(2014) Tatyana A. Shelkovnikova et al.   HUMAN MOLECULAR GENETICS

Physiological IgM Class Catalytic Antibodies Selective for Transthyretin Amyloid

(2014) Stephanie A. Planque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro

(2014) Nikolai Lorenzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal-dependent amyloid β-degrading catalytic antibody construct

(2014) Yasuhiro Nishiyama et al.   JOURNAL OF BIOTECHNOLOGY

Multiple Factors Contribute to the Peripheral Induction of Cerebral  -Amyloidosis

(2014) Y. S. Eisele et al.   JOURNAL OF NEUROSCIENCE

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

(2014) Veronica Lindström et al.   NEUROBIOLOGY OF DISEASE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Aggregate-Depleted Brain Fails to Induce Aβ Deposition in a Mouse Model of Alzheimer's Disease

(2014) Claudia Duran-Aniotz et al.   PLoS One

Exploring the Influence of EGCG on the β-Sheet-Rich Oligomers of Human Islet Amyloid Polypeptide (hIAPP1–37) and Identifying Its Possible Binding Sites from Molecular Dynamics Simulation

(2014) Qianqian Wang et al.   PLoS One

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

(2014) C. B. Cooley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

(2013) Florence Clavaguera et al.   ACTA NEUROPATHOLOGICA

Altered Unfolded Protein Response Is Implicated in the Age-Related Exacerbation of Proteinuria-Induced Proximal Tubular Cell Damage

(2013) Naoko Takeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic Stabilization of Transthyretin, Cerebrovascular Disease, and Life Expectancy

(2013) Louise S. Hornstrup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex

(2013) Matthew C. Smith et al.   BIOCHEMISTRY

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

From Soluble Aβ to Progressive Aβ Aggregation: Could Prion-Like Templated Misfolding Play a Role?

(2013) Yvonne S. Eisele   BRAIN PATHOLOGY

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice

(2013) Götz Heilbronner et al.   EMBO REPORTS

Control of AA amyloidosis complicating Crohn's disease: a clinico-pathological study

(2013) Marie A. Denis et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

De novo generation of infectious prions with bacterially expressed recombinant prion protein

(2013) Zhihong Zhang et al.   FASEB JOURNAL

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau

(2013) Jing L. Guo et al.   FEBS LETTERS

Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

(2013) Maria Udan-Johns et al.   HUMAN MOLECULAR GENETICS

Heat Shock Response Activation Exacerbates Inclusion Body Formation in a Cellular Model of Huntington Disease

(2013) Kirill Bersuker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

(2013) Teresa Coelho et al.   JOURNAL OF NEUROLOGY

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Broadly Applicable Methodology for the Rapid and Dosable Small Molecule-Mediated Regulation of Transcription Factors in Human Cells

(2013) Matthew D. Shoulders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ

(2013) Kanchan Garai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin light chain amyloidosis

(2013) Giampaolo Merlini et al.   Expert Review of Hematology

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01

(2013) Aida Attar et al.   Translational Neuroscience

Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone

(2013) David J. Irwin et al.   JAMA Neurology

Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation

(2012) Sidhartha M. Chafekar et al.   ACS Chemical Biology

Amyloidosis in autoinflammatory syndromes

(2012) Laura Obici et al.   AUTOIMMUNITY REVIEWS

Analysis of the Inhibition and Remodeling of Islet Amyloid Polypeptide Amyloid Fibers by Flavanols

(2012) Ping Cao et al.   BIOCHEMISTRY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Green tea halts progression of cardiac transthyretin amyloidosis: an observational report

(2012) Arnt V. Kristen et al.   Clinical Research in Cardiology

Imbalance of Hsp70 family variants fosters tau accumulation

(2012) Umesh K. Jinwal et al.   FASEB JOURNAL

Pathogenic Serum Amyloid A 1.1 Shows a Long Oligomer-rich Fibrillation Lag Phase Contrary to the Highly Amyloidogenic Non-pathogenic SAA2.2

(2012) Saipraveen Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-like spread of protein aggregates in neurodegeneration: Figure 1.

(2012) Magdalini Polymenidou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug

(2012) Steven M. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET

(2012) G. Antoni et al.   JOURNAL OF NUCLEAR MEDICINE

Treatment with Biologic Agents Improves the Prognosis of Patients with Rheumatoid Arthritis and Amyloidosis

(2012) TAKESHI KURODA et al.   JOURNAL OF RHEUMATOLOGY

Chaperone networks in protein disaggregation and prion propagation

(2012) Juliane Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Transthyretin Cardiac Amyloidoses in Older North Americans

(2012) Kumar Dharmarajan et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

(2012) Adrienne M Wang et al.   Nature Chemical Biology

Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial

(2012) T. Coelho et al.   NEUROLOGY

Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy

(2012) T. Yamashita et al.   NEUROLOGY

Predicting Regional Neurodegeneration from the Healthy Brain Functional Connectome

(2012) Juan Zhou et al.   NEURON

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

(2011) Tsuyoshi Hamaguchi et al.   ACTA NEUROPATHOLOGICA

Long-term data from the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR)

(2011) H. E. Wilczek et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Cardiac Amyloidosis

(2011) Rodney H. Falk   CIRCULATION

Preclinical development of siRNA therapeutics for AL amyloidosis

(2011) B M Hovey et al.   GENE THERAPY

Hsc70 Protein Interaction with Soluble and Fibrillar α-Synuclein

(2011) Samantha Pemberton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targets for AD treatment: conflicting messages from γ-secretase inhibitors

(2011) Kumar Sambamurti et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

(2011) Maria Teresa Ferretti et al.   NEUROBIOLOGY OF AGING

Protective Role of Heat Shock Proteins in Parkinson’s Disease

(2011) Paolo Aridon et al.   Neurodegenerative Diseases

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Prions

(2011) D. W. Colby et al.   Cold Spring Harbor Perspectives in Biology

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

(2010) Merrill D. Benson et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases

(2010) Michael S. Wolfe   BIOLOGICAL CHEMISTRY

Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30)

(2010) Gösta Holmgren et al.   CLINICAL GENETICS

Targeting Heat Shock Proteins in Tauopathies

(2010) M. DeTure et al.   Current Alzheimer Research

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

Bortezomib With or Without Dexamethasone in Primary Systemic (Light Chain) Amyloidosis

(2010) Efstathios Kastritis et al.   JOURNAL OF CLINICAL ONCOLOGY

Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease

(2010) Mun-Gwan Hong et al.   JOURNAL OF HUMAN GENETICS

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Transthyretin-related amyloidoses and the heart: a clinical overview

(2010) Claudio Rapezzi et al.   Nature Reviews Cardiology

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

A Heavy Heart

(2010) Amy Leigh Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy

(2010) Derya R. Shimshek et al.   PLoS One

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway

(2010) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition

(2009) María Paz Gavilán et al.   AGING CELL

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Hereditary fibrinogen A  -chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation

(2009) A. J. Stangou et al.   BLOOD

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

(2009) L. J. Page et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A case with rheumatoid arthritis and systemic reactive AA amyloidosis showing rapid regression of amyloid deposition on gastroduodenal mucosa after a combined therapy of corticosteroid and etanercept

(2009) Wataru Ishii et al.   RHEUMATOLOGY INTERNATIONAL

Quantification of the Thermodynamically Linked Quaternary and Tertiary Structural Stabilities of Transthyretin and Its Disease-Associated Variants: The Relationship between Stability and Amyloidosis†

(2008) Amy R. Hurshman Babbes et al.   BIOCHEMISTRY

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2

(2008) B. K. Arendt et al.   BLOOD

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases

(2008) Ting-Wei Mu et al.   CELL

Tau Mutations in Neurodegenerative Diseases

(2008) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis

(2008) E Ihse et al.   JOURNAL OF PATHOLOGY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab

(2008) Takeshi Kuroda et al.   RHEUMATOLOGY INTERNATIONAL

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES