Selective autophagy mediated by autophagic adapter proteins

Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1

(2014) Elena Shvets et al.   Autophagy

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Selective turnover of p62/A170/SQSTM1 by autophagy

(2014) Yoshinobu Ichimura et al.   Autophagy

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

GABARAPL1 (GEC1) associates with autophagic vesicles

(2010) Fatima Zahra Chakrama et al.   Autophagy

A reporter cell system to monitor autophagy based on p62/SQSTM1

(2010) Kenneth Bowitz Larsen et al.   Autophagy

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

Selective Autophagy in Cancer Development and Therapy

(2010) Ivan Dikic et al.   CANCER RESEARCH

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

The Evolutionarily Conserved Interaction Between LC3 and p62 Selectively Mediates Autophagy-Dependent Degradation of Mutant Huntingtin

(2010) Ying-Tsen Tung et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Autophagy in infection

(2010) Vojo Deretic   CURRENT OPINION IN CELL BIOLOGY

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

A functional role for the p62–ERK1 axis in the control of energy homeostasis and adipogenesis

(2010) Sang Jun Lee et al.   EMBO REPORTS

New insights into the function of Atg9

(2010) Jemma L. Webber et al.   FEBS LETTERS

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

The Cvt pathway as a model for selective autophagy

(2010) Melinda A. Lynch-Day et al.   FEBS LETTERS

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

(2010) C. Rothenberg et al.   HUMAN MOLECULAR GENETICS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy-related Protein 8 (Atg8) Family Interacting Motif in Atg3 Mediates the Atg3-Atg8 Interaction and Is Crucial for the Cytoplasm-to-Vacuole Targeting Pathway

(2010) Masaya Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic Profiling of Lipopolysaccharide-Activated Macrophages by Isotope Coded Affinity Tagging

(2010) Kristian E. Swearingen et al.   JOURNAL OF PROTEOME RESEARCH

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity

(2010) C. A. Whitehouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment

(2010) P. Kadandale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

(2009) Melanie Schwarten et al.   Autophagy

Mitophagy

(2009) Aviva M. Tolkovsky   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

(2009) Y. Hiruma et al.   BLOOD

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

(2009) Yuxia Zhang et al.   CELL

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

(2009) Nicolas Dupont et al.   Cell Host & Microbe

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Autophagy: links with the proteasome

(2009) Trond Lamark et al.   CURRENT OPINION IN CELL BIOLOGY

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover

(2009) Sarah Waters et al.   FEBS LETTERS

Chaperone-mediated autophagy in health and disease

(2009) Maria Kon et al.   FEBS LETTERS

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration

(2009) Chun-Chi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

(2009) Kazuhiro Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

(2009) Precious J. Lim et al.   JOURNAL OF CELL BIOLOGY

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

(2009) Faraz K. Mardakheh et al.   JOURNAL OF CELL BIOLOGY

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-κB Signalling

(2009) Jed Long et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism

(2009) Jozsef Gal et al.   JOURNAL OF NEUROCHEMISTRY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Listeria monocytogenes ActA-mediated escape from autophagic recognition

(2009) Yuko Yoshikawa et al.   NATURE CELL BIOLOGY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae

(2008) Takuya Kageyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mallory–Denk-bodies: Lessons from keratin-containing hepatic inclusion bodies

(2008) P. Strnad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy

(2008) Jean-Claude Farré et al.   DEVELOPMENTAL CELL

Structural basis of target recognition by Atg8/LC3 during selective autophagy

(2008) Nobuo N. Noda et al.   GENES TO CELLS

A SQSTM1/p62 mutation linked to Paget’s disease increases the osteoclastogenic potential of the bone microenvironment

(2008) Yuko Hiruma et al.   HUMAN MOLECULAR GENETICS

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

(2008) Esther S.P. Wong et al.   HUMAN MOLECULAR GENETICS

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins

(2008) Marie W. Wooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes

(2008) E. Shvets et al.   JOURNAL OF CELL SCIENCE

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

(2008) Christian Pohl et al.   NATURE CELL BIOLOGY

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

(2008) J-P Pursiheimo et al.   ONCOGENE

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Picky Eater: Exploring the Mechanisms of Selective Autophagy in Human Pathologies

(2008) Aniek van der Vaart et al.   TRAFFIC

Use of p62/SQSTM1 antibodies for neuropathological diagnosis

(2007) E. Kuusisto et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY