Emerging regulation and functions of autophagy

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Non-autophagic roles of autophagy-related proteins

(2013) Suresh Subramani et al.   EMBO REPORTS

Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis

(2012) R. E. Griffiths et al.   BLOOD

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

(2012) Claudia Capparelli et al.   CELL CYCLE

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle

(2012) Tregei Starr et al.   Cell Host & Microbe

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Pex3-anchored Atg36 tags peroxisomes for degradation inSaccharomyces cerevisiae

(2012) Alison M Motley et al.   EMBO JOURNAL

Non-apoptotic functions of apoptosis-regulatory proteins

(2012) Lorenzo Galluzzi et al.   EMBO REPORTS

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

(2012) Ying Chang et al.   GASTROENTEROLOGY

Chronic Expression of RCAN1-1L Protein Induces Mitochondrial Autophagy and Metabolic Shift from Oxidative Phosphorylation to Glycolysis in Neuronal Cells

(2012) Gennady Ermak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

(2012) Natalia von Muhlinen et al.   MOLECULAR CELL

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

(2012) C. Di Malta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function and Molecular Mechanism of Acetylation in Autophagy Regulation

(2012) C. Yi et al.   SCIENCE

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

New Targets for Acetylation in Autophagy

(2012) A. Hamai et al.   Science Signaling

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis

(2011) Hilla Weidberg et al.   DEVELOPMENTAL CELL

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

(2011) Caroline Bruns et al.   JOURNAL OF CELL BIOLOGY

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella

(2011) Shun Kageyama et al.   MOLECULAR BIOLOGY OF THE CELL

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses

(2011) Emmanuel Eggermann et al.   NATURE REVIEWS NEUROSCIENCE

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction

(2011) Sho W. Suzuki et al.   PLoS One

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

(2011) Christian Frezza et al.   PLoS One

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Glutaminolysis yields a metabolic by-product that stimulates autophagy

(2010) Christina H. Eng et al.   Autophagy

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

(2010) Fulvio Reggiori et al.   Cell Host & Microbe

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Unconventional secretion ofPichia pastorisAcb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation

(2010) Ravi Manjithaya et al.   JOURNAL OF CELL BIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

(2010) Molly A. Lynch-Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Multiple roles of the cytoskeleton in autophagy

(2009) Iryna Monastyrska et al.   BIOLOGICAL REVIEWS

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Autophagy: Regulation and role in disease

(2009) Alfred J. Meijer et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mantle skewness and ridge segmentation

(2009) Satish C. Singh et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

(2009) J. S. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities

(2008) Tito Calì et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium

(2008) M A Mellén et al.   CELL DEATH AND DIFFERENTIATION

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA