Article
Oncology
Nikola Zmarzly, Szymon Januszyk, Pawel Mieszczanski, Emilia Morawiec, Paulina Buda, Konrad Dziobek, Marcin Oplawski, Dariusz Boron
Summary: This study found that the expression of endothelins changes in endometrial cancer, and this may be mainly due to the silencing of EDN3 activity caused by DNA methylation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Serkan Akis, Canan Kabaca, Esra Keles, Ugur Kemal Ozturk, Eser Ozyurek, Murat Api, Handan Cetiner, Evrim Bostanci
Summary: The study identified tumor diameter as an independent predictor for lymphatic dissemination, with a 10 mm increase in diameter increasing the risk of lymph node involvement tenfold. This finding could potentially lead to a reevaluation of the need for lymphadenectomy or adjuvant radiotherapy based on tumor diameter models in the future.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Cell Biology
Kazuhisa Hachisuga, Yoshihiro Ohishi, Hiroshi Tomonobe, Hideaki Yahata, Kiyoko Kato, Yoshinao Oda
Summary: G1 endometrioid carcinoma in the elderly is more aggressive than in the young, and elderly status is an independent predictor of shorter progression-free survival. It is suggested that type 1 tumors can be subdivided into type 1a (young age at onset and indolent) and type 1b (old age at onset and relatively aggressive).
Review
Endocrinology & Metabolism
Jun Guan, Xiao-Jun Chen
Summary: Progestin therapy is the main treatment for preserving fertility in women with endometrial cancer and atypical endometrial hyperplasia. Studies suggest that metformin may have potential benefits in improving the therapeutic outcome of progestin treatment. However, there is still a lack of strong evidence supporting the use of metformin in this context due to heterogeneity and design limitations in existing studies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Mathilde Maire, Aurelien Bourdon, Isabelle Soubeyran, Carlo Lucchesi, Frederic Guyon, Guillaume Babin, Anne Floquet, Adeline Petit, Jessica Baud, Valerie Velasco, Denis Querleu, Sabrina Croce
Summary: This study describes the transcriptomic landscape associated with lymph node metastases in endometroid endometrial carcinomas and generated a 54-gene expression signature that can predict lymph node invasion pre-operatively.
Article
Multidisciplinary Sciences
Igor Govorov, Sanaz Attarha, Larysa Kovalevska, Emil Andersson, Elena Kashuba, Miriam Mints
Summary: The expression of STK4 in endometrial cancer (EC) is associated with patient prognosis, particularly in serous tumors where higher expression is correlated with worse prognosis. The determination of STK4 expression pattern could serve as a potential prognostic marker for serous EC.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Marcin Oplawski, Robert Nowakowski, Agata Srednicka, Dominika Ochnik, Beniamin Oskar Grabarek, Dariusz Boron
Summary: Modern diagnostics focus on molecular analysis and the search for new molecular markers. This study evaluated the differences in mRNA and miRNA expression related to endometrial cancer grades, aiming to select promising molecular markers. The analysis identified potential diagnostic markers associated with epithelial-mesenchymal transition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Dariusz Boron, Robert Nowakowski, Beniamin Oskar Grabarek, Nikola Zmarzly, Marcin Oplawski
Summary: The study investigated the expression profile of leptin-related genes in endometrial cancer patients, showing an overexpression of leptin and its receptors, particularly correlating with patient body mass index, which may contribute to the progression of cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Jung Hwan Ahn, Dong Choon Park, Joo Hee Yoon, Sung Jong Lee, Jimin Cha, Ji Geun Yoo, Hae Nam Lee, Sang Il Kim
Summary: This study aimed to compare the oncologic outcomes of minimally invasive surgery and open surgery in patients with non-endometrioid endometrial cancer. The study found that minimally invasive surgery showed similar survival outcomes to open surgery in non-endometrioid endometrial cancer patients, regardless of disease stage. Therefore, non-endometrioid histological subtypes should not be considered a contraindication for minimally invasive surgery when managed by expert surgeons.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Logan Blankenship, Uday P. Pratap, Xue Yang, Zexuan Liu, Kristin A. Altwegg, Bindu Santhamma, Kumaraguruparan Ramasamy, Swapna Konda, Yidong Chen, Zhao Lai, Siyuan Zheng, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Hareesh B. Nair, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Summary: The study demonstrates that obese conditions upregulate LIF/LIFR signaling, promoting progression of endometrioid endometrial cancer (EEC). The LIFR inhibitor EC359 shows potential in suppressing tumor progression in obese patients.
Article
Pathology
Shiho Asaka, Ying Liu, Zheng-Cheng Yu, Yohan Suryo Rahmanto, Motoki Ono, Ryoichi Asaka, Tsutomu Miyamoto, Ting -Tai Yen, Ayse Ayhan, Tian -Li Wang, Ie-Ming Shih
Summary: Loss of ARID1A expression is associated with decreased PR expression in human and murine endometrial epithelial neoplasia, suggesting that ARID1A regulates PR transcription by modulating the PgR enhancer region during early tumor development.
Article
Oncology
Marko Hojnik, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: The study found that AKR1B1 and AKR1B10 play protective roles in endometrioid endometrial cancer and have the potential as prognostic biomarkers. Patients with higher immunohistochemical levels of both AKR1B1 and AKR1B10 showed better survival rates. However, no significant differences were observed in patients with serous endometrial cancer.
Review
Oncology
Margot De Marco, Antonia Falco, Roberta Laccarino, Antonio Raffone, Antonio Mono, Maurizio Guida, Alessandra Rosati, Massimiliano Chetta, Giovanni Genovese, Francesco De Caro, Mario Capunzo, Maria Caterina Turco, Vladimir N. Uversky, Liberato Marzullo
Summary: BAG3, a multidomain protein, plays a role in cellular processes such as apoptosis, autophagy, and cytoskeletal dynamics. It has been reported to promote cell survival and resistance to therapy in certain tumors, and its expression is associated with ovarian, endometrial, and cervical cancers. Additionally, the interaction of BAG3 with human papillomavirus proteins may contribute to our understanding of virus-induced oncogenesis.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Asa Akesson, Claudia Adok, Pernilla Dahm-Kahler
Summary: This study investigated the recurrences and survival of endometrioid endometrial cancer (EC) and found a low overall recurrence rate, with only a small portion of recurrences limited to the vaginal area, which had a better prognosis compared to other sites of recurrence. Age, FIGO stage, and adjuvant treatment were identified as independent prognostic factors for recurrence.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Pathology
Lawrence Hsu Lin, Douglas H. R. Allison, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, Britta Weigelt, Marc Ladanyi, Nadeem R. Abu-Rustum, Matija Snuderl, Sarah Chiang
Summary: This study found that co-occurring sporadic endometrioid endometrial carcinoma (EEC) and endometrioid ovarian carcinoma (EOC) are clonally related, but there is a shift in DNA methylation signatures between the ovarian and endometrial tumors. The results also indicate epigenetic overlap between ovarian and peritoneal tumors, suggesting a role for the tumor microenvironment in the epigenetic modulation of metastatic EEC.
Article
Public, Environmental & Occupational Health
Ida Pino, Gaia Maria Belloni, Valeria Barbera, Eugenio Solima, Davide Radice, Stefano Angioni, Saverio Arena, Valentino Bergamini, Massimo Candiani, Antonio Maiorana, Alberto Mattei, Ludovico Muzii, Luca Pagliardini, Maria Grazia Porpora, Valentino Remorgida, Renato Seracchioli, Paolo Vercellini, Fulvio Zullo, Errico Zupi, Michele Vignali
Summary: The mean diagnostic delay of symptomatic endometriosis in Italy is about 11 years, with patients under the age of 20 experiencing a delay of up to 4 years. There is no significant association between a delayed diagnosis and clinically relevant factors such as the severity of symptoms or the method of diagnosis.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Article
Pharmacology & Pharmacy
Anna Basile, Carla Zannella, Margot De Marco, Giuseppina Sanna, Gianluigi Franci, Massimiliano Galdiero, Aldo Manzin, Vincenzo De Laurenzi, Massimiliano Chetta, Alessandra Rosati, Maria Caterina Turco, Liberato Marzullo
Summary: Researchers have developed a specific antibody against IFITM2 that can interfere with the invasion of SARS-CoV-2 and reduce its damage to host cells. This antibody also reduces the damage caused by other viruses such as HSV and RSV, suggesting that IFITM2 may have a similar mechanism of invasion to other viruses. These results demonstrate the specific role of IFITM2 in viral entry and its potential as a cell target for antiviral therapies.
ANTIVIRAL RESEARCH
(2023)
Review
Cell Biology
Alessandro Caputo, Alessia Caleo, Immacolata Cozzolino, Pio Zeppa, Giuseppe Ciancia, Valeria Ciliberti
Summary: COVID-19 vaccine-associated clinical lymphadenopathy (C19-LAP) and subclinical lymphadenopathy (SLDI) have been observed after the introduction of RNA-based vaccines during the pandemic. Fine needle aspiration cytology (FNAC) has been used to diagnose these conditions. This review compared the clinical and LN-FNAC features of SLDI and C19-LAP with non-Covid (NC)-LAP.
Review
Surgery
Maria Addesso, Alessandro Caputo, Pio Zeppa, Antonio D'Antonio
Summary: This article reports a rare case of prostatic stromal sarcoma. Despite surgical and chemotherapeutic interventions, the patient's condition did not improve. This case highlights the diagnostic and therapeutic challenges of prostatic stromal sarcoma.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Oncology
Alessandro Caputo, Filippo Fraggetta, Pasquale Cretella, Immacolata Cozzolino, Albino Eccher, Ilaria Girolami, Stefano Marletta, Giancarlo Troncone, Elena Vigliar, Gennaro Acanfora, Karen Villar Zarra, Hector Enrique Torres Rivas, Guido Fadda, Andrew Field, Ruth Katz, Philippe Vielh, Catarina Eloy, Arvind Rajwanshi, Nalini Gupta, Mousa Al-Abbadi, Nadwa Bustami, Tala Arar, Maria Calaminici, Juliet I. Raine, Helena Barroca, Pedro Amoroso Canao, Mats Ehinger, Nilofar Rajabian, Pranab Dey, L. Jeffrey Medeiros, Siba El Hussein, Oscar Lin, Antonio D'Antonio, Beata Bode-Lesniewska, Esther Diana Rossi, Pio Zeppa
Summary: This study assessed the interobserver reproducibility of the Sydney system in lymph node cytopathology. The results showed that the Sydney system demonstrates adequate interobserver concordance in lymph node cytopathology.
CANCER CYTOPATHOLOGY
(2023)
Article
Cell Biology
Valeria Ciliberti, Elisabetta Maffei, Angela D'Ardia, Francesco Sabbatino, Bianca Serio, Antonio D'Antonio, Pio Zeppa, Alessandro Caputo
Summary: The combination of FNAC and CNB in one setting improves the diagnostic accuracy of both procedures. CNB confirms or improves the FNAC diagnosis in the majority of cases and allows for diagnoses that cannot be reached by FNAC alone. The combined approach resulted in actionable diagnoses in the majority of cases.
Article
Medical Laboratory Technology
Riccardo Ruotolo, Elisabetta Maffei, Francesco Sabbatino, Bianca Serio, Pio Zeppa, Alessandro Caputo
Summary: Leptomeningeal metastasis is a severe complication of cancer, commonly seen in high-grade lymphomas, leukemias, and some solid tumors. Accurate diagnosis and optimal care for patients with leptomeningeal metastasis require sample collection and processing, comprehensive clinical history, interdisciplinary dialog, and the use of ancillary techniques such as immunocytochemistry and flow cytometry.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Article
Oncology
Marco Picardi, Claudia Giordano, Elena Vigliar, Pio Zeppa, Imma Cozzolino, Novella Pugliese, Roberta Della Pepa, M. Esposito, Davide Pio Abagnale, Mauro Ciriello, Giada Muccioli-Casadei, Giancarlo Troncone, Daniela Russo, M. Mascolo, Silvia Varricchio, Rossella Accarino, Massimo Persico, Fabrizio Pane
Summary: This study aimed to evaluate the reliability and safety of front-line ultrasonography guided core needle biopsy (UG-CNB) for lymphadenopathies suspected of lymphoma. By retrospectively reviewing the results of lymph node UG-CNB from four Italian clinical units over a 12-year period, it was found that the overall accuracy was 97% and the complication rate was low.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Massimiliano Chetta, Anna Lisa Cammarota, Margot De Marco, Nenad Bukvic, Liberato Marzullo, Alessandra Rosati
Summary: Climate change and globalization have increased the risk of vector-borne diseases in Europe. In Italy, tropical vectors have been found to carry viruses causing viral encephalitis. The World Health Organization has recommended measures to prevent the spreading of infectious agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Immunology
Alessandra Rosati, Liberato Marzullo, Margot De Marco, Vincenzo De Laurenzi, Maria Francesca D'Amico, Maria Caterina Turco
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Anna Lisa Cammarota, Antonia Falco, Anna Basile, Carlo Molino, Massimiliano Chetta, Gianni D'Angelo, Liberato Marzullo, Margot De Marco, Maria Caterina Turco, Alessandra Rosati
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis, and a more detailed understanding of its biology is needed to develop effective therapies. This article discusses the role of cancer-secreted proteins in the complex tumor microenvironment and tumor-stroma crosstalk, highlighting potential molecular targets for the development of innovative, safer, and more efficient therapeutic strategies.
Article
Medicine, General & Internal
Monica Cavallo, Valeria Ciliberti, Elisabetta Maffei, Bianca Serio, Francesco Sabbatino, Pio Zeppa, Alessandro Caputo
Summary: This study calculates the cost and diagnostic accuracy of using FNAC as a first-line procedure for diagnosing lymphadenopathy. It finds that in 74% of cases, FNAC alone can provide sufficient diagnosis, avoiding the need for surgical biopsy. This approach reduces costs, avoids invasive procedures, and allows for earlier diagnosis.
Review
Obstetrics & Gynecology
Antonio Travaglino, Antonio Raffone, Diego Raimondo, Annarita Gencarelli, Italia Esposito, Cinzia Gallo, Francesco Paolo Improda, Salvatore Giovanni Vitale, Antonio Mollo, Paolo Casadio, Renato Seracchioli, Fulvio Zullo, Luigi Insabato
Summary: Loss of Bcl-2 expression is a significant prognostic marker but not a diagnostic marker in uLMS. Further research and larger studies are needed to confirm this finding.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)