The Natural Compound Cantharidin Induces Cancer Cell Death through Inhibition of Heat Shock Protein 70 (HSP70) and Bcl-2-associated Athanogene Domain 3 (BAG3) Expression by Blocking Heat Shock Factor 1 (HSF1) Binding to Promoters

Cantharidin as an Antitumor Agent: A Retrospective Review

(2013) L.P. Deng et al.   CURRENT MEDICINAL CHEMISTRY

The Stress Protein BAG3 Stabilizes Mcl-1 Protein and Promotes Survival of Cancer Cells and Resistance to Antagonist ABT-737

(2013) Mariana Boiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways

(2012) Gernot Walter et al.   CELL CYCLE

DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin

(2012) A Mitra et al.   ONCOGENE

PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway

(2011) Wei Li et al.   CANCER LETTERS

Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis

(2010) Wei Li et al.   CANCER SCIENCE

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to thehsp70Promoter

(2010) Young Ju Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins

(2009) Aaron T. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway

(2009) Angela M. Keuling et al.   PLoS One

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway

(2008) Morihiko Sagawa et al.   CANCER SCIENCE

New insights into the mechanism of heat shock response activation

(2008) I. Shamovsky et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Liposome encapsulation reduces cantharidin toxicity

(2008) Chun-Chao Chang et al.   FOOD AND CHEMICAL TOXICOLOGY

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Development and application of Hsp90 inhibitors

(2007) D SOLIT   DRUG DISCOVERY TODAY